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Catalog	name	Description	price
R-C-1242	GSK269962A CAS:850664-21-0	GSK269962A(GSK 269962)is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively.GSK269962A has anti-inflammatory and vasodilatory activities.	price>
R-R-2942	Indusatumab CAS No.1497400-26-6	Indusatumab (5F9 Monoclonal antibody)/CAS No.1497400-26-6 is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody.	price>
R-C-1243	CPI-169 CAS:1450655-76-1	CPI-169(CPI 169 R-enantiomer)is a novel and potent EZH2 inhibitor,with IC50s of 0.24 nM,0.51 nM,and 6.1nM for EZH2 WT,EZH2 Y641N,and EZH1,respectively.	price>
R-R-2943	LY83583 CAS No.91300-60-6	LY83583/CAS No.91300-60-6 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM.	price>
R-C-1244	cpi-360 CAS:1802175-06-9	CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2,respectively.	price>
R-R-2944	Zagociguat CAS No.2201048-82-8	Zagociguat/CAS No.2201048-82-8 is the stimulator of soluble guanylate cyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders.	price>
R-C-1245	u73122 CAS:112648-68-7	U-73122 is a potent phospholipase C inhibitor or PI-PLC inhibitor.U-73122 is widely used as a tool to investigate the involvement of the phosphoinositide-specific phospholipase C(PLC)in signal transduction,particularly in studies attempting to characterize pathways leading to intracellular Ca2+ mobilization upon agonist challenge.U-73122 directly blocks PLC isoenzymes in vivo and in vitro.	price>
R-R-2945	Plecanatide CAS No.467426-54-6	Plecanatide/CAS No.467426-54-6, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.	price>
R-C-1246	Arry-520 (Filanesib) CAS:885060-09-3	Filanesib,also known as ARRY-520,is a synthetic,small molecule targeting the kinesin spindle protein(KSP)with potential antineoplastic activity.KSP inhibitor ARRY-520 specifically inhibits KSP(kinesin-5 or Eg5),resulting in activation of the spindle assembly checkpoint,induction of cell cycle arrest during the mitotic phase,and consequently cell death in tumor cells that are actively dividing.KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.	price>
R-R-2946	(Rac)-MGV354 CAS No.1852495-86-3	(Rac)-MGV354/CAS No.1852495-86-3 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.	price>
R-C-1247	DBeQ CAS：177355-84-9	DBeQ,also known as JRF 12,is a selective,reversible,and ATP-competitive inhibitor of the ATPase p97 for treatment of cancer.DBeQ impairs both ubiquitin-dependent and autophagic protein clearance pathways.DBeQ was shown to inhibit the ATPase activity of Vps4 with an IC50 of about 11.5 μM.To a less degree,it also inhibits hyphal growth.DBeQ blocks multiple processes that have been shown by RNAi to depend on p97,including degradation of ubiquitin fusion degradation and endoplasmic reticulum-associated degradation pathway reporters,as well as autophagosome maturation.	price>
R-R-2947	BAY 41-8543 CAS No.256498-66-5	BAY 41-8543/CAS No.256498-66-5 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research.	price>
R-C-1248	Pseudolaric Acid B(PBA) CAS： 82508-31-4	Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden(pinaceae),has anti-cancer,antifungal,and antifertile activities,and shows immunosuppressive activity on T lymphocytes.Pseudolaric Acid B inhibits hepatitis B virus(HBV)secretion through apoptosis and cell cycle arrest.Pseudolaric Acid B induces autophagy.	price>
R-R-2948	BAY-747 CAS No.1609342-18-8	BAY-747/CAS No.1609342-18-8 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model.	price>
R-C-1249	BIIB021(CNF2024) CAS：848695-25-0	BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.	price>
R-R-2949	Nelociguat CAS No.625115-52-8	Nelociguat (BAY60-4552)/CAS No.625115-52-8 is a nitric oxide sensitive soluble guanylate cyclase stimulator.	price>
R-C-1250	GLPG0634 analogue CAS：1206101-20-3	GLPG0634-analogue is an analogue of Filgotinib or GLPG0634,is a potent and selective JAK1 inhibitor.	price>
R-R-2950	Plecanatide acetate CAS No.1075732-84-1	Plecanatide acetate/CAS No.1075732-84-1, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis.	price>
R-C-1251	TG003 CAS： 300801-52-9	TG003 is a potent and ATP-competitive Cdc2-like kinase(Clk)inhibitor with IC50 of 20 nM,200 nM,and 15 nM for Clk1,Clk2,and Clk4,respectively.No inhibitory effect on Clk3,SRPK1,SRPK2,or PKC.	price>
R-R-2951	MM 419447 CAS No.1092457-78-7	MM 419447/CAS No.1092457-78-7, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).	price>

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