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Catalog	name	Description	price
R-C-1272	NVP-231 CAS：362003-83-6	NVP-231 is a potent,specific,and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP-231 is active in the low nanomolar range on purified as well as cellular CerK and abrogates phosphorylation of ceramide,resulting in decreased endogenous C1P levels.When combined with another ceramide metabolizing inhibitor,such as tamoxifen,NVP-231 synergistically increased ceramide levels and reduced cell growth.Therefore.NVP-231 represents a novel and promising compound for controlling ceramide metabolism that may provide insight into CerK physiological function.	price>
R-R-2972	MRTX0902 CAS No.2654743-22-1	MRTX0902/CAS No.2654743-22-1 is an orally active and potent SOS1 inhibitor with an IC50 of 46 nM (WO2021127429A1; Example 12-10).	price>
R-C-1273	PCI-27483 CAS No. 871266-63-6	PCI-27483 is a reversible small-molecule inhibitor of activated factor VII (factor VIIa)with potential antineoplastic and antithrombotic activities.FVII,a serine protease,becomes activated(FVII)aupon binding with TF forming the FVIIa/TF complex,which induces intracellular signaling pathways by activating protease activated receptor 2(PAR-2).Upon subcutaneous administration,factor VIIa inhibitor PCI-27483 selectively inhibits factor FVIIa in the VIIa/TF complex,which may prevent PAR-2 activation and PAR2-mediated signal transduction pathways,thereby inhibiting tumor cell proliferation,angiogenesis,and metastasis of TF-overexpressing tumor cells.	price>
R-R-2973	Opnurasib CAS No.2653994-08-0	Opnurasib (JDQ-443) (NVP-JDQ443)/CAS No.2653994-08-0 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity.	price>
R-C-1274	BMS754807 CAS：1001350-96-4	BMS-754807 is an efficacious,orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.	price>
R-R-2974	LC-2 CAS No.2502156-03-6	LC-2/CAS No.2502156-03-6 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines.	price>
R-C-1275	JNJ 31020028 CAS No. 1094873-14-9	JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07,human;pIC50=8.22 rat);>100-fold selective versus human Y1/Y4/Y5 receptors.	price>
R-R-2975	RMC-6291 CAS No.2641998-63-0	RMC-6291/CAS No.2641998-63-0 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. RMC-6291 inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. RMC-6291 also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM.	price>
R-C-1276	CHS 828 CAS：200484-11-3	CHS-828(GMX1778)is a competitive inhibitor of nicotinamide phosphoribosyltransferase(NAMPT),with an IC50 less than 25 nM.CHS-828 (GMX1778)exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity.	price>
R-R-2976	CASIN CAS No.425399-05-9	CASIN/CAS No.425399-05-9 is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer.	price>
R-C-1277	CK 1827452 CAS：873697-71-3	Omecamtiv mecarbil, also known as CK-1827452,is a cardiac specific myosin activator.It is clinically tested for its role in the treatment of left ventricular systolic heart failure.Omecamtiv Mecarbil specifically targets and activates myocardial ATPase and improves energy utilization.Omecamtiv Mecarbil improves systolic function by increasing the systolic ejection duration/stroke volume,without consuming more ATP energy,oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency.	price>
R-R-2977	Salirasib CAS No.162520-00-5	Salirasib/CAS No.162520-00-5 is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.	price>
R-C-1278	LP-533401 CAS：945976-43-2	LP533401 is an inhibitor of tryptophan hydroxylase 1,which regulates serotonin production in the gut.LP533401 has an anabolic effect in bone.Inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis.	price>
R-R-2978	ML-098 CAS No.878978-76-8	ML-098 (CID-7345532)/CAS No.878978-76-8 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.	price>
R-C-1279	Vesnarinone CAS:81840-15-5	Vesnarinone is a cardiotonic agent,mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest,dose-dependent,positive inotropic activity,but minimal negative chronotropic activity.Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.	price>
R-R-2979	RAS-IN-2 CAS No.2765081-21-6	RAS-IN-2 (Compound A122)/CAS No.2765081-21-6 is a potent RAS(ON)MULTI inhibitor and can be used for the research of cancer.	price>
R-C-1280	AZ-33 CAS：1370290-34-8	AZ-33(LDHA Inhibitor 33)is a potent inhibitor of lactate dehydrogenase A (LDHA)with IC50 of 0.5 μM.LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	price>
R-R-2980	MRTX-1257 CAS No.2206736-04-9	MRTX-1257/CAS No.2206736-04-9 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.	price>
R-C-1281	(Linsitinib)OSI-906 CAS：867160-71-2	Linsitinib(OSI-906)is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays;modestly potent to InsR with IC50 of 75 nM,and no activity towards Abl,ALK,BTK,EGFR,FGFR1/2,PKA etc.	price>
R-R-2981	FTI-277 hydrochloride CAS No.180977-34-8	FTI-277 hydrochloride/CAS No.180977-34-8 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.	price>

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