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Catalog	name	Description	price
R-C-1411	ML-365 CAS:947914-18-3	ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM.ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels.	price>
R-R-3111	Metergoline CAS No.17692-51-2	Metergoline/CAS No.17692-51-2 is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.	price>
R-C-1412	CHIR-98014 CAS:252935-94-7	CHIR-98014 is a potent,cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β,respectively;it shows less potent activities against cdc2 and erk2.	price>
R-R-3112	Spiperone CAS No.749-02-0	Spiperone/CAS No.749-02-0 is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Spiperone is a widely used pharmacological tool. Spiperone has the potential for the research of neurology diseases.	price>
R-C-1413	G-749 CAS:1457983-28-6	G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD,FLT3-D835Y,FLT3-ITD/N676D,and FLT3-ITD/F691L in cellular assays.G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma,FLT3 ligand surge,and stromal protection.	price>
R-R-3113	Mirtazapine CAS No.85650-52-8	Mirtazapine (Org3770)/CAS No.85650-52-8 is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively.	price>
R-C-1414	Pyridostain CAS:1085412-37-8	Pyridostatin(RR82)is a G-quadruplex DNA stabilizing agent(Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication-and transcription-dependent DNA damage.Pyridostatin targets the proto-oncogene Src.Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.	price>
R-R-3114	Ketanserin tartrate CAS No.83846-83-7	Ketanserin (R41468) tartrate/CAS No.83846-83-7 is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).	price>
R-C-1415	KPT330 CAS:1393477-72-9	KPT-330 inhibitor of CRM1(XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.	price>
R-R-3115	Pimavanserin hemitartrate CAS No.706782-28-7	Pimavanserin (ACP-103) hemitartrate/CAS No.706782-28-7 is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.	price>
R-C-1416	Verdinexor (KPT-335) CAS: 1392136-43-4	Verdinexor（KPT-335)is an orally bioavailable Selective Inhibitor of Nuclear Export(SINE).KPT-335 inhibited proliferation,blocked colony formation,and induced apoptosis of treated cells at biologically relevant concentrations of drug.Additionally,KPT-335 downregulated XPO1 protein while inducing a concomitant increase in XPO1 messenger RNA.KPT-335 treatment of cell lines upregulated the expression of both protein and mRNA for the tumor suppressor proteins p53 and p21,and promoted their nuclear localization.	price>
R-R-3116	Prucalopride CAS No.179474-81-8	Prucalopride/CAS No.179474-81-8 is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.	price>
R-C-1417	KPT276 CAS:1421919-75-6	KPT-276 is an orally bioavailable inhibitor of Exportin 1(XPO1/CRM1)with anticancer activity.In vivo,KPT-276 increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia(AML)mouse xenograft model.	price>
R-R-3117	8-OH-DPAT hydrobromide CAS No.76135-31-4	8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide/CAS No.76135-31-4 is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.	price>
R-C-1418	Siponimod (BAF312) CAS:1230487-00-9	BAF312(Siponimod)is a next-generation S1P receptor agonist,selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM,exhibits >1000-fold selectivity over S1P2,S1P3 and S1P4 receptors.	price>
R-R-3118	S1RA hydrochloride CAS No.1265917-14-3	S1RA (E-52862) hydrochloride/CAS No.1265917-14-3 is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization.	price>
R-R-3119	Loxapine CAS No.1977-10-2	Loxapine/CAS No.1977-10-2 is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.	price>
R-C-1420	HM71224 CAS :1353552-97-2	Poseltinib,an orally active,selective and irreversible Bruton? is tyrosine kinase (BTK)inhibitor(IC50=1.95 nM),with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX,TEC and TXK,respectively.	price>
R-R-3120	Tandospirone CAS No.87760-53-0	Tandospirone (SM-3997)/CAS No.87760-53-0 is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms.	price>
R-C-1421	PIK293 CAS:900185-01-5	PIK-293,an analog of IC87114,is a PI3K inhibitor,with IC50 values of 0.24 μM,10μM,25μM and 100μM for p110δ,p110β,p110γ and p110α,respectively.	price>

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