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Catalog	name	Description	price
R-R-3131	LP-211 CAS No.1052147-86-0	LP-211/CAS No.1052147-86-0 is a selective and blood−brain barrier penetrant 5-HT7 receptor agonist, with a Ki of 0.58 nM, with high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).	price>
R-C-1432	Trovafloxacin CAS：147059-72-1	Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive,Gram-negative and anaerobic organisms.Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity.Trovafloxacin is also a potent,selective and orally active pannexin 1 channel(PANX1)inhibitor with an IC50 of 4 μM for PANX1 inward current.Trovafloxacin does not inhibit connexin 43 gap junction or PANX2.Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.	price>
R-R-3132	Lurasidone Hydrochloride CAS No.367514-88-3	Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride))/CAS No.367514-88-3 is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.	price>
R-C-1433	LDC000067 CAS：1073485-20-7	LDC000067 is a potent and selective CDK9 inhibitor.LDC000067 inhibited in vitro transcription in an ATP-competitive and dose-dependent manner.Gene expression profiling of cells treated with LDC000067 demonstrated a selective reduction of short-lived mRNAs,including important regulators of proliferation and apoptosis. Analysis of de novo RNA synthesis suggested a wide ranging positive role of CDK9.At the molecular and cellular level,LDC000067 reproduced effects characteristic of CDK9 inhibition such as enhanced pausing of RNA polymerase II on genes and, most importantly,induction of apoptosis in cancer cells.LDC000067 inhibits P-TEFb-dependent in vitro transcription.Induces apoptosis in vitro and in vivo in combination with BI 894999.	price>
R-R-3133	Levomepromazine CAS No.60-99-1	Levomepromazine (Methotrimeprazine)/CAS No.60-99-1 is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors.	price>
R-C-1434	GSK137647A CAS：349085-82-1	GSK137647A is an agonist of the free fatty acid receptor 4(FFA4/GPR120)with pEC50s=6.3,6.2,and 6.1 at human,mouse,and rat receptors,respectively.GSK137647A is selective for GPR120 over a panel of 61 other targets,including other FFARs.	price>
R-R-3134	Gamma-Mangostin CAS No.31271-07-5	Gamma-Mangostin/CAS No.31271-07-5 is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) .	price>
R-C-1435	LLY-507 CAS：1793053-37-8	LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2,LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50<15 nM.LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.	price>
R-R-3135	Roluperidone CAS No.359625-79-9	Roluperidone (CYR-101)/CAS No.359625-79-9 is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).	price>
R-C-1436	HLCL-61 HCL CAS：1158279-20-9	HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia.HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML(acute myeloid leukemia)cells.As a result,significant antileukemic activity was achieved.The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it.In AML cells,PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3.	price>
R-R-3136	Syk Inhibitor II CAS No.726695-51-8	Syk Inhibitor II/CAS No.726695-51-8 is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect.	price>
R-C-1437	AG18 CAS：118409-57-7	AG-18（RG-50810;RG-50858;TX 825;Tyrphostin A23;Tyrphostin AG-18）AG-18 is an inhibitor of epidermal growth factor(EGF)receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431.AG-18 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex.	price>
R-R-3137	R 59-022 CAS No.93076-89-2	R 59-022 (DKGI-I)/CAS No.93076-89-2 is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.	price>
R-C-1438	CYM5442 CAS：1094042-01-9	CYM5442 is a potent,highly-selective and orally active sphingosine 1-phosphate (S1P1)receptor agonist with an EC50 of 1.35 nM.CYM5442 is inactive against S1P2,S1P3,S1P4,and S1P5.CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation.CYM5442 exerts retinal neuroprotection.CYM5442 can easily penetrate the central nervous system(CNS).	price>
R-R-3138	Paliperidone palmitate CAS No.199739-10-1	Paliperidone palmitate (9-Hydroxyrisperidone palmitate)/CAS No.199739-10-1, an atypical long-acting antipsychotic agent, is an ester proagent of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.	price>
R-C-1439	u-104 CAS：178606-66-1	U-104(SLC-0111)is a potent carbonic anhydrase(CA)inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM,respectively.U-104 shows a significant delay in tumor growth in mice model.	price>
R-R-3139	Prucalopride succinate CAS No.179474-85-2	Prucalopride succinate/CAS No.179474-85-2 is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.	price>
R-C-1440	OAC1 CAS：300586-90-7	OAC1 is an Oct-4 activator,octamer-binding transcription factor 4(Oct4)-activating compound,that enhances the iPSC reprogramming efficiency and accelerated the reprogramming process by 20-fold.OAC-1 also upregulates mRNA expression of Oct-4,Sox-2 and Nanog,as well as Tet1.	price>
R-R-3140	Rotigotine CAS No.99755-59-6	Rotigotine/CAS No.99755-59-6 is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor.	price>
R-C-1441	OAC2 CAS：6019-39-2	OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.Octamer-binding transcription factor 4(Oct4)is a transcription factor which,with Sox2,Klf4,and c-Myc,is involved in the reprogramming of somatic cells to produce pluripotent stem cells.	price>

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