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Catalog	name	Description	price
R-R-3141	Granisetron Hydrochloride CAS No.107007-99-8	Granisetron (Hydrochloride) (BRL 43694A)/CAS No.107007-99-8 is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.	price>
R-R-3142	Palonosetron hydrochloride CAS No.135729-62-3	Palonosetron hydrochloride/CAS No.135729-62-3 is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).	price>
R-C-1443	Apilimod (STA-5326) CAS：541550-19-0	Apilimod(STA-5326)is a potent and orally-available inhibitor of the cytokines interleukin-12(IL-12)and interleukin-23(IL-23)with the potential to treat certain autoimmune and inflammatory diseases.Apilimod(STA-5326)inhibits IL-12 with IC50 of 1 nM,1 nM and 2 nM,in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs,respectively.Apilimod (STA-5326)is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.	price>
R-R-3143	Sarpogrelate hydrochloride CAS No.135159-51-2	Sarpogrelate hydrochloride (MCI-9042)/CAS No.135159-51-2 is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis.	price>
R-C-1444	Santacruzamate A (CAY10683) CAS:1477949-42-0	Santacruzamate A(CAY10683)is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2,>3600-fold selectivity over other HDACs.	price>
R-R-3144	Sarizotan CAS No.351862-32-3	Sarizotan (EMD 128130)/CAS No.351862-32-3 is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.	price>
R-C-1445	PRE-084 hydrochloride CAS:75136-54-8	AZ084 is a potent,selective,allosteric and oral active CCR8 antagonist,with a Ki of 0.9 nM.Has potential to treat asthma.	price>
R-R-3145	Alosetron Hydrochloride CAS No.122852-69-1	Alosetron Hydrochloride (GR 68755C)/CAS No.122852-69-1 is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.	price>
R-C-1446	GSK8573 CAS:1693766-04-9	GSK8573(compound 23)is an inactive control compound for GSK2801.GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy.	price>
R-R-3146	NAS-181 dimesylate CAS No.1217474-40-2	NAS-181 dimesylate/NAS181/CAS No.1217474-40-2 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.	price>
R-C-1447	Torin2 CAS:1223001-51-1	Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/−MEFs cell line;800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties.Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively.Torin 2 decreases cell viability and induces autophagy and apoptosis.	price>
R-R-3147	Spadin TFA	Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research.	price>
R-C-1448	BML-210(CAY10433) CAS:537034-17-6	BML-210(CAY10433),is HDAC inhibitor.BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.BML-210 can inhibit cell growth and induce apoptosis in cervical cancer cells,what correlates with down-regulation of HDAC class I and II and changes in the DAPC expression levels.	price>
R-R-3148	Harmine hydrochloride CAS No.343-27-1	Harmine Hydrochloride (Telepathine Hydrochloride)/CAS No.343-27-1 is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.	price>
R-C-1449	TC-H 106 CAS:937039-45-7	TC-H 106(Pimelic Diphenylamide 106)is a slow,tight-binding inhibitor of class I histone deacetylases(HDAC)with Ki value of 148 nM,about 102 nM,14 nM for HDAC1,HDAC2,HDAC3,respectively.	price>
R-R-3149	Perospirone CAS No.150915-41-6	Perospirone (SM-9018 free base)/CAS No.150915-41-6 is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.	price>
R-C-1450	UF 010 CAS:537672-41-6	UF-010 is a Class I HDAC inhibitor(IC50 values are 0.06,0.1,0.5 and 1.5μM for HDACs 3,2,1 and 8,respectively).UF010 inhibits cancer cell proliferation via class I HDAC inhibition.This causes global changes in protein acetylation and gene expression,resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways.	price>
R-R-3150	AS19 CAS No.1000578-26-6	AS19/CAS No.1000578-26-6 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia.	price>
R-C-1451	KC7F2 CAS:927822-86-4	KC7F2 is an inhibitor of HIF-1αprotein translation,but not transcription,that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1(4EBP1)and p70 S6 kinase(S6K).	price>
R-R-3151	2-Methyl-5-HT CAS No.78263-90-8	2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine)/CAS No.78263-90-8 is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects.	price>

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