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Catalog	name	Description	price
R-R-3085	SEP-363856 hydrochloride CAS No.1310422-41-3	SEP-363856 hydrochloride (SEP-856 hydrochloride)/CAS No.1310422-41-3, an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride (SEP-856 hydrochloride) has the potential for the study of schizophrenia.	price>
R-C-1386	PF-3758309 CAS: 898044-15-0	PF-3758309,also known as PF-03758309,is a PAK4 inhibitor,is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4(PAK4)with potential antineoplastic activity.PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth.PAK4,a serine/threonine kinase belonging to the p21-activated kinase(PAK)family,is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility,proliferation,and survival.	price>
R-R-3086	Volinanserin CAS No.139290-65-6	Volinanserin/CAS No.139290-65-6 is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.	price>
R-C-1387	Preladenant CAS:377727-87-2	Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.	price>
R-R-3087	Ritanserin CAS No.87051-43-2	Ritanserin (R 55667)/CAS No.87051-43-2 is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.	price>
R-C-1388	CWHM12 CAS:1564286-55-0	CWHM 12 can suppress all 5 alpha V integrins.CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method,it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.	price>
R-R-3088	Paliperidone CAS No.144598-75-4	Paliperidone (9-Hydroxyrisperidone)/CAS No.144598-75-4, the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.	price>
R-C-1389	NMS-873 CAS:1418013-75-8	NMS-873 is a potent, allosteric and specific VCP inhibitor(also known as p97 inhibitor)with IC50 of 30 nM.NMS-873 activated the unfolded protein response, interfered with autophagy and induced cancer cell death.The consistent pattern of cancer cell killing by covalent and allosteric inhibitors provided critical validation of VCP as a cancer target.	price>
R-R-3089	Vortioxetine hydrobromide CAS No.960203-27-4	Vortioxetine hydrobromide/CAS No.960203-27-4 is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-C-1390	Nutlin-3 CAS：890090-75-2	Nutlin-3,also known as(±)-Nutlin-3 and N-6287,is a p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment.Nutlin-3 specifically targets p53-Mdm2 interaction offers new therapeutic opportunities by enhancing cancer cell growth arrest and apoptosis through the restoration of the p53-mediated tumor suppression pathway while producing minimal cytotoxicity and side effects. Nutlin-3 reverses the epithelial-mesenchymal transition in gemcitabine-resistant hepatocellular carcinoma cells.Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity.	price>
R-R-3090	WAY-100635 maleate CAS No.1092679-51-0	WAY-100635 maleate/CAS No.1092679-51-0 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist.	price>
R-C-1391	Deltarasin CAS：1440898-61-2	Deltazinone is highly potent and selective PDEδ inhibitor.Deltazinone exhibits less unspecific cytotoxicity than the previously reported Deltarasin and demonstrates a high correlation with the phenotypic effect of PDEδ knockdown in a set of human pancreatic cancer cell lines.	price>
R-R-3091	8-OH-DPAT CAS No.78950-78-4	8-OH-DPAT /CAS No.78950-78-4 is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).	price>
R-C-1392	VX745 CAS：209410-46-8	Neflamapimod,also known as VX-745,VRT-031745 and VD-31745, is highly potent and selective p38α inhibitor(IC50=10 nM).VX-745 blocks TNFα production in LPS-stimulated HWB in vitro(IC50=177 nM).VX-745 displays excellent enzyme activity and selectivity,has a favorable pharmacokinetic profile,and demonstrates good in vivo activity in models of inflammation.	price>
R-R-3092	Quetiapine CAS No.111974-69-7	Quetiapine (ICI204636)/CAS No.111974-69-7 is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.	price>
R-C-1393	Nirogacestat (PF-03084014) CAS：1290543-63-3	Nirogacestat,also known as PF-03084014,is a potent and selective gamma secretase (GS)inhibitor with potential antitumor activity.PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors.Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer.Nirogacestat enhances docetaxel-mediated tumor response and provides a rationale to explore GSIs as adjunct therapy in conjunction with docetaxel for men with CRPC(castration-resistant prostate cancer).	price>
R-R-3093	BW-723C86 CAS No.160521-72-2	BW-723C86/CAS No.160521-72-2 is a potent and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats.	price>
R-C-1394	RO4938581 CAS：883093-10-5	RO 4938581 is a potent and selective GABAA α5 inverse agonist,with a Ki of 4.6 nM for GABAA α5β3γ2a,and shows a lower affinity at α1β3γ2a,α2β3γ2a, α3β3γ2a (Ki,174,185,80 nM,respectively).	price>
R-R-3094	Alprenolol hydrochloride CAS No.13707-88-5	Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride/CAS No.13707-88-5 is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent.	price>
R-C-1395	ARQ621 CAS：1095253-39-6	ARQ-621 is an allosteric,potent and selective inhibitor of Eg5,a microtubule-based ATPase motor protein involved in cell division.Over-expression of Eg5 causes genomic instability and tumor formation in mice;therefore,Eg5 is a potential anti-cancer target.Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies.	price>

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