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Catalog	name	Description	price
R-C-1452	WDR5 0103 CAS:890190-22-4	WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5(Kd= 450 nM),inhibiting the catalytic activity of the MLL core complex in vitro (IC50=39 µM).WD repeat domain 5(WDR5)plays an important role in various biological functions through the epigenetic regulation of gene transcription. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis.	price>
R-R-3152	Oxatomide CAS No.60607-34-3	Oxatomide/CAS No.60607-34-3 is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.	price>
R-C-1453	MN 64 CAS:92831-11-3	MN-64 is a potent tankyrase 1 inhibitor,with IC50s of 6 nM,72 nM,19.1μM,and 39.4μM for TNKS1,TNKS2,ARTD1 and ARTD2,respectively.	price>
R-R-3153	CP94253 hydrochloride CAS No.845861-39-4	CP94253 hydrochloride/CAS No.845861-39-4 is a potent and selective agonist of 5-HT1B receptor (Ki= 2 nM in a radioligand binding assay).Ki values for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors are 89, 49, 860, and 1600 nM respectively. CP94253 hydrochloride is centrally active upon systemic administration in vivo.	price>
R-C-1454	NCH 51 CAS:848354-66-5	PTACH(NCH-51)is a potent HDAC inhibitor with IC50s of 48 nM,32 nM,and 41 nM for HDAC1,HDAC4,and HDAC6,respectively.PTACH exerts potent growth inhibition against various cancer cells(EC50s of 1.1-9.1 µM) .	price>
R-R-3154	Setiptiline CAS No.57262-94-9	Setiptiline (Org-8282)/CAS No.57262-94-9 is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.	price>
R-C-1455	Betahistine CAS:5638-76-6	Betahistine is a histamine analog and H1 receptor agonist that serves as a vasodilator.It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.Betahistine dihydrochloride is an anti-vertigo drug.It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière is disease.It was first registered in Europe in 1970 for the treatment of Ménière is disease.	price>
R-R-3155	Setiptiline maleate CAS No.85650-57-3	Setiptiline maleate (MO-8282 maleate)/CAS No.85650-57-3 is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.	price>
R-C-1456	NSC19005(Betahistine EP Impurity C) CAS:5452-87-9	Betahistine EP Impurity C(NSC19005)is an impurity of Betahistine.Betahistine is a potent,orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis(RA).	price>
R-R-3156	Lumateperone tosylate CAS No.1187020-80-9	Lumateperone (ITI-007) tosylate/CAS No.1187020-80-9 is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.	price>
R-C-1457	NKL 22 CAS:537034-15-4	NKL 22 is a HDAC inhibitor.The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrations NKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes. HDAC inhibitors act directly on FXN.	price>
R-R-3157	(Z)-Thiothixene CAS No.3313-26-6	(Z)-Thiothixene/CAS No.3313-26-6 is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.	price>
R-C-1458	FPS-ZM1 CAS:945714-67-0	FPS-ZM1 is a blood-brain-barrier permeant,non-toxic,tertiary amide compound which is a high affinity RAGE-specific inhibitor,blocking Aβ binding to the V domain of RAGE.	price>
R-R-3158	Eletriptan hydrobromide CAS No.177834-92-3	Eletriptan hydrobromide (Eletriptan HBr)/CAS No.177834-92-3 is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.	price>
R-C-1459	PYRACLONIL CAS：158353-15-2	Pyraclonil is a proporphyrinogen oxidase(PPO)inhibitor.Pyraclonil is a herbicide agent and is highly effective in controlling the susceptible(S)and multiple-herbicide-resistant(MHR)E.indica populations.	price>
R-R-3159	SB 258719 CAS No.195199-95-2	SB 258719/CAS No.195199-95-2 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease.	price>
R-C-1460	Mitoquinone CAS:444890-41-9	Mitoquinone is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage.	price>
R-R-3160	Ziprasidone hydrochloride monohydrate CAS No.138982-67-9	Ziprasidone (CP-88059) hydrochloride monohydrate/CAS No.138982-67-9 is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone hydrochloride monohydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).	price>
R-C-1461	ASC-J9 CAS:52328-98-0	Dimethylcurcumin(ASC-J9,Dimethyl curcumin,GO-Y025)is an androgen receptor (AR)degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.	price>
R-R-3161	Jatrorrhizine hydroxide CAS No.483-43-2	Jatrorrhizine hydroxide/CAS No.483-43-2 is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.	price>

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