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Catalog	name	Description	price
R-C-1482	CNX-2006 CAS：1375465-09-0	CNX-2006 is a potent,mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations,as well as in cells harbouring the T790M mutation.CNX-2006 is the prototype for CO-1686,which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.	price>
R-R-3182	Mirtazapine-d3 CAS No.1216678-68-0	Mirtazapine-d3/CAS No.1216678-68-0 is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors.	price>
R-C-1483	Verteporfin (CL 318952) CAS：129497-78-5	Verteporfin(CL 318952,Visudyne)is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth.It is also a potent second-generation photosensitizing agent derived from porphyrin.Verteporfin is an autophagy inhibitor.Verteporfin inhibits cell proliferation and induces apoptosis.	price>
R-R-3183	WAY-181187 CAS No.554403-49-5	WAY-181187 (SAX-187)/CAS No.554403-49-5 is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.	price>
R-C-1484	Cyclopamine CAS：4449-51-8	Cyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids.It is a teratogen isolated from the corn lily (Veratrum californicum)that causes usually fatal birth defects.It can prevent the fetal brain from dividing into two lobes(holoprosencephaly)and cause the development of a single eye(cyclopia).	price>
R-R-3184	SB 243213 CAS No.200940-22-3	SB 243213/CAS No.200940-22-3 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.	price>
R-C-1485	Bleomycin Sulfate(NSC125066) CAS：9041-93-4	Bleomycin Sulfate(NSC125066)is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas(SCC)with IC50 of 4 nM in UT-SCC-19A cells.	price>
R-R-3185	R 59-022 hydrochloride CAS No.93076-98-3	R 59-022 (DKGI-I) hydrochloride/CAS No.93076-98-3 is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.	price>
R-C-1486	Carboplatin (NSC 241240) CAS：41575-94-4	Carboplatin is a chemotherapy drug used against some forms of cancer(mainly ovarian carcinoma,lung,head and neck cancers).Cisplatin and carboplatin,as well as oxaliplatin,interact with DNA,akin to the mechanism of alkylating agents.	price>
R-R-3186	SB-277011 hydrochloride CAS No.215804-67-4	SB-277011 hydrochloride (SB-277011A hydrochloride)/CAS No.215804-67-4 is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor (D3R) antagonist with Ki values of 10.7 nM and 11.2 nM at rodent and human D3R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pKis of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.	price>
R-C-1487	Pazopanib (GW786034) CAS：444731-52-6	Pazopanib(GW786034)is a novel multi-target inhibitor of VEGFR1,VEGFR2,VEGFR3,PDGFRβ,c-Kit,FGFR1,and c-Fms with IC50s of 10,30,47, 84,74,140 and 146 nM,respectively.	price>
R-R-3187	Dolasetron CAS No.115956-12-2	Dolasetron(MDL-73147)/CAS No.115956-12-2 is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.	price>
R-C-1488	U0126-EtOH CAS：1173097-76-1	U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays,100-fold higher affinity for N3-S218E/S222D MEK than PD98059.U0126 inhibits autophagy and mitophagy with antiviral activity.	price>
R-R-3188	Tandospirone citrate CAS No.112457-95-1	Tandospirone citrate/CAS No.112457-95-1 is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).	price>
R-C-1489	Fulvestrant (ICI-182780) CAS：129453-61-8	Fulvestrant(ICI-182780,ZD 9238,ZM 182780)is an estrogen recepto(ER)antagonist with IC50 of 0.94 nM in a cell-free assay.Fulvestrant also induces autophagy and apoptosis and has antitumor activity.	price>
R-R-3189	Tropisetron Hydrochloride CAS No.105826-92-4	Tropisetron Hydrochloride (SDZ-ICS-930)/CAS No.105826-92-4 is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.	price>
R-C-1490	Decitabine (NSC 127716) CAS：2353-33-5	Decitabine(NSC 127716,Deoxycytidine,Dacogen,5-aza-2-deoxycytidine,5-AZA-dC, 5-aza-CdR)is a DNA methyltransferase inhibitor,incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome(MDS).Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.	price>
R-R-3190	Nelotanserin CAS No.839713-36-9	Nelotanserin/CAS No.839713-36-9 is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.	price>
R-R-3191	Pumosetrag Hydrochloride CAS No.194093-42-0	Pumosetrag Hydrochloride (MKC-733; DDP-733)/CAS No.194093-42-0 is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.	price>
R-C-1492	Bicalutamide (ICI-176334) CAS：90357-06-5	Bicalutamide is a synthetic,nonsteroidal antiandrogen.Bicalutamide competitively binds to cytosolic androgen receptors in target tissues,thereby inhibiting the receptor binding of androgens.This agent does not bind to most mutated forms of androgen receptors.	price>

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