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Catalog	name	Description	price
R-R-3202	DSP-1053 CAS No.1176326-76-3	DSP-1053/CAS No.1176326-76-3, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity.	price>
R-C-1503	CH5132799 (PA-799) CAS:1007207-67-1	CH5132799(PA-799)is a novel class I PI3K inhibitor,which exhibited a strong inhibitory activity especially against PI3Kα(IC(50)=0.014μM).In human tumor cell lines with PI3K pathway activation,CH5132799 showed potent antiproliferative activity.CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice.CH5132799 selectively inhibited class I PI3Ks and PI3Kα mutants in in vitro kinase assays.Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models.	price>
R-R-3203	5-HT2B antagonist-1 CAS No.393129-91-4	5-HT2B antagonist-1/CAS No.393129-91-4 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.	price>
R-C-1504	azd2932 CAS:883986-34-3	AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR.AZD-2932 has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes,respectively.It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases.	price>
R-R-3204	3-Hydroxy agomelatine CAS No.166526-99-4	3-Hydroxy agomelatine/CAS No.166526-99-4 is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM.	price>
R-C-1505	xmd8-92 CAS:1234480-50-2	XMD8-92 is a potent ERK5(BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively.XMD8-92 inhibits DCAMKL2,PLK4 and TNK1 with Kds of 190,600 and 890 nM,respectively.Anti-cancer activity.	price>
R-R-3205	Velusetrag CAS No.866933-46-2	Velusetrag (TD-5108)/CAS No.866933-46-2 is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors.	price>
R-C-1506	mps1in-2 CAS:1228817-38-6	Mps1-IN-2 is a potent,selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.	price>
R-R-3206	Flesinoxan CAS No.98206-10-1	Flesinoxan/CAS No.98206-10-1 is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects.	price>
R-C-1507	gne7915 CAS：1351761-44-8	GNE-7915 is a potent LRRK2 kinase inhibitor,which possess an ideal balance of LRRK2 cellular potency,broad kinase selectivity,metabolic stability,and brain penetration across multiple species.GNE-7915 was reported as a potent(IC50=9nM) selective(1/187 kinases),brain-penetrant and non-toxic inhibitor of LRRK2.	price>
R-R-3207	Opiranserin hydrochloride CAS No.1440796-75-7	Opiranserin (VVZ-149) hydrochloride/CAS No.1440796-75-7, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain.	price>
R-C-1508	LXR-623 (WAY-252623) CAS：875787-07-8	LXR-623(WAY-252623)is a novel liver X-receptor(LXR)agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β,respectively.It is orally bioavailable and readily passes the blood-brain barrier.	price>
R-R-3208	Dehydroaripiprazole CAS No.129722-25-4	Dehydroaripiprazole (OPC-14857)/CAS No.129722-25-4 is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.	price>
R-C-1509	mbx2982 CAS：1037792-44-1	MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119(GPR119),a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion.	price>
R-R-3209	p-MPPI hydrochloride CAS No.220643-77-6	p-MPPI hydrochloride/CAS No.220643-77-6 is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects.	price>
R-C-1510	BI-7273 CAS：1883429-21-7	BI-7273 is a selective,and cell-permeable BRD9 inhibitor,with an IC50 and a Kd of 19 and 0.75 nM;also shows high effect on BRD7,with an IC50 and a Kd of 117 nM and 0.3 nM.	price>
R-R-3210	Deramciclane CAS No.120444-71-5	Deramciclane/CAS No.120444-71-5 has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist.	price>
R-C-1511	kobe0065 CAS：436133-68-5	Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.	price>
R-R-3211	Arotinolol CAS No.68377-92-4	Arotinolol/CAS No.68377-92-4 is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.	price>
R-C-1512	AAL-993 cas:269390-77-4	AAL-993 is a potent,selective and cell-permeable inhibitor of VEGFR-1(IC₅₀=130 nM),VEGFR-2(IC₅₀=23 nM)and VEGFR-3(IC₅₀=18nM).At higher concentrations it inhibits PDGFR(640 nM),c-Kit(236 nM)and CSF-1R(380 nM).Inactive at other kinases such as EGFR,FGFR-1,CDK-1,Tie-2,c-Met,IGF-1R,c-Src and c-Abl.	price>

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