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Catalog	name	Description	price
R-R-3212	Valerenic acid CAS No.3569-10-6	Valerenic acid ((-)-Valerenic Acid)/CAS No.3569-10-6, a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties.	price>
R-C-1513	Tenovin-6 CAS：1011557-82-6	Tenovin-6 is a analog of tenovin-1.Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1,SIRT2,and SIRT3 in vitro with IC50 values of 21,10,and 67uM,respectively.	price>
R-R-3213	Urapidil hydrochloride CAS No.64887-14-5	Urapidil hydrochloride/CAS No.64887-14-5 is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect.	price>
R-C-1514	T0070907 CAS：313516-66-4	T0070907 is a potent and selective PPARγinhibitor with IC50 of 1 nM in a cell-free assay,with a>800-fold selectivity over PPARα and PPARδ.T0070907 significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells.	price>
R-R-3214	Ecopipam hydrobromide CAS No.2587360-22-1	Ecopipam (SCH 39166) hydrobromide/CAS No.2587360-22-1 is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.	price>
R-C-1515	YYA-021 CAS:144217-65-2	YYA-021 is a small-molecule CD4 mimic that inhibits HIV entry,with high anti-HIV activity and low cytotoxicity.	price>
R-R-3215	PRX-08066 CAS No.866206-54-4	PRX-08066/CAS No.866206-54-4 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.	price>
R-C-1516	RS1 CAS:312756-74-4	RS-1 is a RAD51 activator,and also increases CRISPR/Cas9-mediated knock-in efficiencies.	price>
R-R-3216	Befiradol CAS No.208110-64-9	Befiradol (NLX-112)/CAS No.208110-64-9 is a selective 5-HT1A receptor agonist.	price>
R-C-1517	C-DIM12 CAS:178946-89-9	C-DIM12 is a novel synthetic activator of Nurr1.C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)model of PD in mice.C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown.C-DIM12 increased expression of transfected human Nurr1,induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.	price>
R-R-3217	Melitracen hydrochloride CAS No.10563-70-9	Melitracen hydrochloride/CAS No.10563-70-9 is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space.	price>
R-C-1518	BTZ043 CAS:1161233-85-7	BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase(DprE1),with MICs of of 2.3 nM and 9.2 nM for M.tuberculosis H37Rv and Mycobacterium smegmatis, respectively.	price>
R-R-3218	Piromelatine CAS No.946846-83-9	Piromelatine (Neu-P11)/CAS No.946846-83-9 is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities.	price>
R-C-1519	PBTZ169 CAS:1377239-83-2	Macozinone(PBTZ169)is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2-oxidase)inhibitor.	price>
R-R-3219	Geissoschizine methyl ether CAS No.60314-89-8	Geissoschizine methyl ether/CAS No.60314-89-8, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT1A receptor agonist.	price>
R-C-1520	TMS CAS:24144-92-1	TMS is a potent,selective and competitive inhibitor of cytochrome P450 1B1,an enzyme overexpressed in certain tumors(IC50=6 nM).5N/A-and 520-fold selective over P450 1A1 and 1A2 respectively.	price>
R-R-3220	Tianeptine CAS No.72797-41-2	Tianeptine/CAS No.72797-41-2 is a selective facilitator of 5-HT uptake. Tianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine has antidepressant, anxiolytic, analgesic and neuroprotective activities.	price>
R-C-1521	Compound 401 CAS：168425-64-7	Compound 401 is a synthetic inhibitor of DNA-PK(IC50=0.28 μM) and mTOR(IC50=5.3μM).It has no inhibition on p110α/p85α PI3K(>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.	price>
R-R-3221	MK-212 monohydrochloride CAS No.61655-58-1	MK-212 (CPP) monohydrochloride/CAS No.61655-58-1 is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.	price>
R-C-1522	SMER28 CAS：307538-42-7	SMER28 is a small-molecule enhancer(SMER)of autophagy,inducing autophagy independently of rapamycin in mammalian cells.	price>

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