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Catalog	name	Description	price
R-R-3222	Vabicaserin hydrochloride CAS No.887258-94-8	Vabicaserin hydrochloride/CAS No.887258-94-8 is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM.	price>
R-C-1523	AZ876 CAS:898800-26-5	AZ876 is a potent and high-affinity LXR agonist.AZ876 displays 25-fold and 2.5-fold more potent than GW3965(HY-10627)on human(h)LXRα and hLXRβ respectively.	price>
R-R-3223	Quipazine dimaleate CAS No.150323-78-7	Quipazine dimaleate/CAS No.150323-78-7 is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.	price>
R-C-1524	Paxalisib (GDC-0084) CAS:1382979-44-3	Paxalisib(GDC-0084,RG7666)is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM,46 nM,3 nM,10 nM and 70 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR.	price>
R-R-3224	Desmethyl cariprazine CAS No.839712-15-1	Desmethyl cariprazine/CAS No.839712-15-1 is an active metabolite of Cariprazine. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).	price>
R-C-1525	CWHM-12 CAS:1564286-55-0	CWHM 12 can suppress all 5 alpha V integrins.CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method,it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.	price>
R-R-3225	Frovatriptan succinate hydrate CAS No.158930-17-7	Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate)/CAS No.158930-17-7 is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research.	price>
R-C-1526	ABT-639 CAS:1235560-28-7	ABT-639 is a potent and selective T-type calcium channel blocker.ABT-639 effectively reduces nociceptive and neuropathic pain in rats.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.ABT-639 was significantly less active at other Ca²⁺channels(e.g.Ca(v)1.2 and Ca(v)2.2) (IC50>30μM).ABT-639 has high oral bioavailability(%F=73),low protein binding(88.9%)and a low brain:plasma ratio(0.05:1)in rodents.	price>
R-R-3226	Fananserin CAS No.127625-29-0	Fananserin (RP 62203)/CAS No.127625-29-0 is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor.	price>
R-C-1527	SH-4-54 CAS:1456632-40-8	SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5,respectively.SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs)and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.Moreover,in vivo,SH-4-54 exhibited blood-brain barrier permeability,potently controlled glioma tumor growth,and inhibited pSTAT3 in vivo.	price>
R-R-3227	RS-102221 hydrochloride CAS No.187397-18-8	RS-102221 hydrochloride/CAS No.187397-18-8 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats.	price>
R-C-1528	CHIR-090 CAS: 728865-23-4	CHIR-090 is a potent,slow,tight-binding inhibitor of the LpxC deacetylase.It binds to E.coli LpxC with a Ki of 4.0nM.	price>
R-R-3228	Bemesetron CAS No.40796-97-2	Bemesetron (MDL 72222)/CAS No.40796-97-2 is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect.	price>
R-C-1529	MS023 CAS:1831110-54-3	MS023 is a potent,selective,and cell-active inhibitor of human type I protein arginine methyltransferases(PRMTs)inhibitor,with IC50s of 30,119,83,4 and 5nM for PRMT1,PRMT3,PRMT4,PRMT6,and PRMT8,respectively.	price>
R-R-3229	Altanserin CAS No.76330-71-7	Altanserin/CAS No.76330-71-7 can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors.	price>
R-C-1530	GSK591（EPZ-015866） CAS:1616391-87-7	GSK591(EPZ015866)is a potent and selective inhibitor of protein methyltransferase 5(PRMT5)with an IC50 of 4 nM.	price>
R-R-3230	Agomelatine-d6 CAS No.1079389-42-6	Agomelatine-d6/CAS No.1079389-42-6 is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors .	price>
R-C-1531	Binimetinib (MEK-162, ARRY-162, ARRY-438162)	Binimetinib(MEK162)is an oral and selective MEK1/2 inhibitor.Binimetinib (MEK162)inhibits MEK with an IC50 of 12 nM.	price>
R-R-3231	SB-203186 hydrochloride CAS No.207572-69-8	SB-203186 hydrochloride/CAS No.207572-69-8 is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively.	price>
R-C-1532	Galeterone CAS:851983-85-2	Galeterone(TOK-001)is a selective CYP17 inhibitor and androgen receptor (AR)antagonist with IC50 of 300 nM and 384 nM,respectively,and is a potent inhibitor of human prostate tumor growth.	price>

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