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Catalog	name	Description	price
R-R-3232	VUF10166 CAS No.155584-74-0	VUF10166/CAS No.155584-74-0 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM.	price>
R-C-1533	GSK163090 CAS:844903-58-8	GSK163090 is a potent,selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7,respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter(SerT)with a pKi value of 6.1.GSK163090 has antidepressant and anxiolytic activities.	price>
R-R-3233	SB-399885 hydrochloride CAS No.402713-81-9	SB-399885 hydrochloride/CAS No.402713-81-9 is a 5-HT6 receptor antagonist.	price>
R-C-1534	AMG319 CAS : 1608125-21-8	AMG-319(ACP319)is a highly selective,potent,and orally bioavailable small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases(PI3K)with potential immunomodulating and antineoplastic activities.PI3K-delta inhibitor AMG 319 prevents the activation of the PI3K signaling pathway through inhibition of the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate(PIP3),thus decreasing proliferation and inducing cell death.	price>
R-R-3234	BMY-14802 hydrochloride CAS No.105565-55-7	BMY-14802 hydrochloride (BMY-14802-1)/CAS No.105565-55-7 is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.	price>
R-C-1535	Vipadenant(BIIB 014) CAS:442908-10-3	Vipadenant,also known as BIIB014,CEB-4520,is a potent,selective and orally available adenosine A2A receptor antagonist under development for Parkinson is disease.Vipadenant demonstrates strong oral activity in commonly used models of Parkinson is disease.	price>
R-R-3235	CP-809101 hydrochloride CAS No.1215721-40-6	CP-809101 hydrochloride/CAS No.1215721-40-6 is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence.	price>
R-C-1536	UNC2025 CAS:1429881-91-3	UNC2025 is a potent,ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively.UNC2025 is>45-fold selectivity for MERTK relative to Axl(IC50=122 nM;Ki=13.3 nM).UNC2025 exhibits an excellent PK properties,and can be used for the investigation of acute leukemia.	price>
R-R-3236	Ramosetron Hydrochloride CAS No.132907-72-3	Ramosetron Hydrochloride(YM060 Hydrochloride)/CAS No.132907-72-3 is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.	price>
R-C-1537	Irbinitinib (ARRY-380) CAS:937263-43-9	Tucatinib(Irbinitinib,ONT-380,ARRY-380)is an oral,potent,selective,reversible and ATP-competitive small-molecule inhibitor of ErbB-2(also called HER2)with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2,respectively in cell-based assays,showing ~500-fold selective for HER2 vs EGFR.It has potential antineoplastic activity.	price>
R-R-3237	Idalopirdine Hydrochloride CAS No.467458-02-2	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride)/CAS No.467458-02-2 is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine Hydrochloride may be used in studies of schizophrenia, among other related disorders.	price>
R-C-1538	CEP-33779 CAS:1257704-57-6	CEP-33779 is a highly selective,orally active,small-molecule inhibitor of JAK2. CEP-33779 induced regression of established colorectal tumors,rRadotinib educed angiogenesis,and reduced proliferation of tumor cells.Tumor regression correlated with inhibition of STAT3 and NF-κB(RelA/p65)activation in a CEP-33779 dose-dependent manner.The ability of CEP-33779 to suppress growth of colorectal tumors by inhibiting the IL-6/JAK2/STAT3 signaling suggests a potential therapeutic utility of JAK2 inhibitors in multiple tumors types, particularly those with a strong inflammatory component.	price>
R-R-3238	cis-Urocanic acid CAS No.7699-35-6	cis-Urocanic acid/CAS No.7699-35-6 is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.	price>
R-C-1539	Liproxstatin-1 CAS: 950455-15-9	Liproxstatin-1 is a potent inhibitor of ferroptosis,a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species(ROS).Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types,and in engineered cells overexpressing oncogenic RAS.	price>
R-R-3239	Cinanserin hydrochloride CAS No.54-84-2	Cinanserin hydrochloride (SQ 10643)/CAS No.54-84-2 is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.	price>
R-C-1540	TPCA-1 CAS:507475-17-4	TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation,DNA binding,and transactivation.	price>
R-R-3240	Masupirdine mesylate CAS No.1791396-46-7	Masupirdine mesylate (SUVN-502 mesylate)/CAS No.1791396-46-7 is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites.	price>
R-C-1541	Rapamycin (Sirolimus) CAS:53123-88-9	Rapamycin(Sirolimus;AY 22989)is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells.Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1.Rapamycin is an autophagy activator,an immunosuppressant.	price>
R-R-3241	Brexpiprazole S-oxide-d8 CAS No.2748605-29-8	Brexpiprazole S-oxide-d8/CAS No.2748605-29-8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.	price>
R-C-1542	Etoposide CAS:33419-42-0	Etoposide(VP-16,VP-16213)is a semisynthetic derivative of podophyllotoxin,which inhibits DNA synthesis via topoisomerase II inhibition activity.Etoposide induces autophagy,mitophagy and apoptosis.	price>

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