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Catalog	name	Description	price
R-R-3252	SB-616234-A CAS No.908601-49-0	SB-616234-A/CAS No.908601-49-0 is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.	price>
R-C-1553	Bay 59-3074 CAS:406205-74-1	Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 55.4 nM,48.3 nM and 45.5nM at rat and human CB1 and human CB2 receptors, respectively.Bay 59-3074 displays analgesic properties.	price>
R-R-3253	Spiramide CAS No.510-74-7	Spiramide (AMI-193)/CAS No.510-74-7 is a potent and selective antagonist of 5-HT2 and dopamine D2 receptor, with Kis of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2 versus 5-HT1C (Ki=4300 nM) receptors. Spiramide exhibits antipsychotic activity.	price>
R-C-1554	PNU282987HCL CAS:123464-89-1	PNU282987 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors.In animal studies,it shows nootropic effects,and derivatives may be useful in the treatment of schizophrenia,although PNU-282,987 is not suitable for use in humans because of excessive inhibition of the hERG antitarget.	price>
R-R-3254	Cerlapirdine CAS No.925448-93-7	Cerlapirdine (SAM-531, PF-05212365)/CAS No.925448-93-7 is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor.	price>
R-C-1555	shp099 CAS:1801747-42-1	SHP099 is a potent,selective,orally available SHP2 inhibitor with an IC50 of 70 nM.	price>
R-R-3255	Usmarapride CAS No.1428862-33-2	Usmarapride (SUVN-D4010)/CAS No.1428862-33-2 is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM).	price>
R-C-1556	Lirametostat (CPI-1205) CAS:1621862-70-1	Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2 with IC50 values of 2 nM and 52 nM for EZH2 and EZH1 respectively. It has potential antineoplastic activity.	price>
R-R-3256	Usmarapride free base CAS No.1428862-32-1	Usmarapride (SUVN-D4010) free base/CAS No.1428862-32-1 is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM).	price>
R-C-1557	GNE-493 CAS:1033735-94-2	GNE-493 is a potent,selective,and orally available dual pan-PI3-kinase/mTOR inhibitor with IC50s of 3.4 nM,12 nM,16nM,16 nM and 32 nM for PI3Kα,PI3Kβ,PI3Kδ,PI3Kγ and mTOR.	price>
R-R-3257	Ampreloxetine CAS No.1227056-84-9	Ampreloxetine (TD-9855)/CAS No.1227056-84-9 is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension.	price>
R-C-1558	SL327 CAS：305350-87-2	SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18μM/0.2μM,no activity towards Erk1,MKK3,MKK4,c-JUN,PKC,PKA,or CamKII;capable of transport through the blood-brain barrier.	price>
R-R-3258	Amitriptyline-d6 hydrochloride CAS No.203645-63-0	Amitriptyline-d6 (hydrochloride)/CAS No.203645-63-0 is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.	price>
R-C-1559	CCG215022 CAS：1813527-81-9	CCG215022 is a potent GRK2 and GRK5 inhibitor.CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA.	price>
R-R-3259	m-CPBG hydrochloride CAS No.2113-05-5	m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride/CAS No.2113-05-5 is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease.	price>
R-C-1560	GSK-6853 CAS：1910124-24-1	GSK6853 is a potent and selective inhibitor of the BRPF1 bromodomain.shows excellent BRPF1 potency(pKd 9.5)and greater than 1600-fold selectivity over all other bromodomains tested.	price>
R-R-3260	RS 39604 CAS No.167710-87-4	RS 39604/CAS No.167710-87-4 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites.	price>
R-C-1561	AM-2394 CAS：1442684-77-6	AM-2394 is a potent and selective Glucokinase agonist(GKA),which catalyzes the phosphorylation of glucose to glucose-6-phosphate.AM-2394 activates GK with an EC50 of 60 nM,increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models,and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.	price>
R-R-3261	Quetiapine-d4 hemifumarate CAS No.1217310-65-0	Quetiapine-d4 (hemifumarate)/CAS No.1217310-65-0 is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects.	price>
R-C-1562	Mivebresib (ABBV-075) CAS：1445993-26-9	Mivebresib(ABBV-075)is a novel BET family bromodomain inhibitor.It binds bromodomains of BRD2/4/Twith similar affinities(Ki of 1-2.2nM)and highly selective for 18 bromodomain proteins tested (Kd>1μM;more than 600-fold selectivity vs.BRD4),but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM)and has moderate activity towards CREBBP(Kd=87μM;54-fold selectivity vs.BRD4).Mivebresib(ABBV-075)efficiently triggers apoptosis in various tumor cell.	price>

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