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Catalog	name	Description	price
R-R-3272	Naronapride CAS No.860174-12-5	Naronapride (ATI-7505)/CAS No.860174-12-5 is a potent prokinetic 5-HT4 receptor agonist. Naronapride can be used for gastrointestinal diseases research.	price>
R-C-1573	ML348 CAS:899713-86-1	ML348 is a selective and reversible lysophospholipase 1(LYPLA1)inhibitor(IC50 =210nM),Exhibits 14-fold selectivity for LYPLA1 over LYPLA2,Also selective over a panel of ~30 other serine hydrolases.	price>
R-R-3273	Amitriptyline-d3 hydrochloride CAS No.342611-00-1	Amitriptyline-d3 hydrochloride/CAS No.342611-00-1 is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.	price>
R-C-1574	mpi-0479605 CAS：1246529-32-7	MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1.Cells treated with MPI-0479605 undergo aberrant mitosis,resulting in aneuploidy and formation of micronuclei.In cells with wild-type p53,this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway.In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis.Subsequently,cells undergo mitotic catastrophe and/or an apoptotic response.In xenograft models, MPI-0479605 inhibits tumor growth,suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics.	price>
R-R-3274	l-Pindolol CAS No.26328-11-0	l-Pindolol ((-)-pindolol)/CAS No.26328-11-0 is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease.	price>
R-C-1575	QVD-oph CAS：1135695-98-5	Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties;inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1,3,8,9,10,and 12.Q-VD-OPh can inhibits HIV infection.Q-VD-OPh is able to cross the blood-brain barrier.	price>
R-R-3275	Pipamperone CAS No.1893-33-0	Pipamperone (Floropipamide; McN-JR 3345; R 3345)/CAS No.1893-33-0 is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7).	price>
R-C-1576	VX497（Merimepodib） CAS：198821-22-6	Merimepodib(Merimempodib,MMPD,VI-21,497,VX-497)is a potent,specific,and reversible inosine monophosphate dehydrogenase(IMPDH)inhibitor with antiviral activity against hepatitis C virus(HCV)and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent.	price>
R-R-3276	Org-12962 CAS No.132834-56-1	Org-12962/CAS No.132834-56-1 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.	price>
R-C-1577	FLLL32 CAS:1226895-15-3	FLLL32,a synthetic analog of curcumina,is a JAK2/STAT3 dual inhibitor with anti-tumor activity.FLLL32 can inhibit the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.	price>
R-R-3277	Spiroxatrine CAS No.1054-88-2	Spiroxatrine (R 5188)/CAS No.1054-88-2 is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.	price>
R-C-1578	JK184 CAS:315703-52-7	JK-184 is a potent downstream hedgehog(Hh)signaling inhibitor that prevents Gli-dependent transcriptional activity(IC50=30nM).JK184 can specially inhibit Gli in the Hedgehog(Hh)pathway,which showed great promise for cancer therapeutics.	price>
R-R-3278	LY-272015 hydrochloride CAS No.172895-15-7	LY-272015 hydrochloride/CAS No.172895-15-7 is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats.	price>
R-C-1579	VU0364770 CAS:61350-00-3	VU 0364770 is a positive allosteric modulator(PAM)of mGlu4 with EC50 of 1.1 μM,exhibits insignificant activity at 68 other receptors,including other mGlu subtypes.	price>
R-R-3279	(E)-3,4,5-Trimethoxycinnamic acid CAS No.20329-98-0	(E)-3,4,5-Trimethoxycinnamic acid (TMCA)/CAS No.20329-98-0 is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy.	price>
R-C-1580	VU0361737 CAS:1161205-04-4	VU 0361737 is a selective positive allosteric modulator(PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors,respectively,displays weak activity at mGlu5 and mGlu8 receptors,is inactive at mGlu1,mGlu2,mGlu3,mGlu6 and mGlu7 receptors,can penetrate into CNS.	price>
R-R-3280	YM348 CAS No.372163-84-3	YM348/CAS No.372163-84-3 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM).	price>
R-R-3281	ST1936 CAS No.1210-81-7	ST1936/CAS No.1210-81-7 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor.	price>
R-C-1581	NU7026 CAS:154447-35-5	NU7026(LY293646)is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays,60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.NU7026 enhances G2/M cell arrest and apoptosis.	price>
R-C-1582	Motolimod (VTX-2337) CAS:926927-61-9	Motolimod(VTX-2337)is a selective and potent Toll-like receptor 8(TLR8)agonist with EC50 of 100 nM,>50-fold selectivity over TLR7.	price>

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