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Catalog	name	Description	price
R-C-1781	JNJ 42153605 CAS：1254977-87-1	JNJ-42153605 is a potent and selective mGlu2 receptor PAM with an acceptable pharmacokinetic profile in rodent and nonrodent species.JNJ-42153605 showed centrally mediated in vivo effectivity in models sensitive to mGlu2 receptor modulation such as sleep−wake electroencephalogram in rats,34 showing suppressed REM sleep during the first 4 h after oral administration of a 3 mg/kg dose.	price>
R-R-3481	H-9 Dihydrochloride CAS No.116700-36-8	H-9 Dihydrochloride/CAS No.116700-36-8 is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 μM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines.	price>
R-C-1782	Ebselen CAS:60940-34-3	Ebselen(SPI-1005)is an inhibitor of HIV-1 capsid CTD dimerization.Ebselen can permeate the blood-brain barrier and inhibit inositol monophosphatase(IMPase). Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties.Ebselen inhibits QSOX1 enzymatic activity and has anticancer activity.	price>
R-R-3482	(S)-Mirtazapine-d3	(S)-Mirtazapine-d3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2.	price>
R-C-1783	Pleconaril(VP 63843,Win 63843) CAS:153168-05-9	Pleconaril(APO-P001,Picovir,VP 63843,WIN 63843)is a capsid inhibitor used previously to treat enterovirus infections.Pleconaril is effective in inhibiting replication with IC50 of<0.050μM.	price>
R-R-3483	(S)-WAY 100135 dihydrochloride CAS No.149007-54-5	(S)-WAY 100135 dihydrochloride/CAS No.149007-54-5 is a highly selective and potent antagonist of 5-HT 1A (IC50=33.9 nM). (S)-WAY 100135 dihydrochloride has anxiolytic activity in animal models.	price>
R-C-1784	Acumapimod (BCT-197) CAS:836683-15-9	Acumapimod(BCT197)is an orally active p38 MAP kinase inhibitor,with an IC50 of less than 1 μM for p38α.	price>
R-R-3484	NEO 376 CAS No.496921-73-4	NEO 376/CAS No.496921-73-4 is a selective modulator of 5-HT1 receptor, GABA receptor and dopamine receptor, with anti-psychotic actively.	price>
R-C-1785	SGC2085 CAS:1821908-48-8	SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1(CARM1)inhibitor with an IC50 value of 50nM and>100-fold selective over other PRMTs.	price>
R-R-3485	Nemonapride CAS No.75272-39-8	Nemonapride/CAS No.75272-39-8 is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.	price>
R-C-1786	WIKI4 CAS:838818-26-1	WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM.WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2.WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02μM.	price>
R-R-3486	ARC 239 CAS No.67339-62-2	ARC 239/CAS No.67339-62-2 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM.	price>
R-C-1787	VGX-1027 CAS：6501-72-0	VGX-1027 displays immunomodulatory and anti-inflammatory activities by inhibiting toll-like receptor 4(TLR4)signaling.	price>
R-R-3487	7-Desmethyl-agomelatine-d3 CAS No.2749427-92-5	7-Desmethyl-agomelatine-d3/CAS No.2749427-92-5 is a deuterium labeled 7-Desmethyl-agomelatine. 7-Desmethyl-agomelatine is a metabolite of Agomelatine.	price>
R-C-1788	TCS OX2 29 CAS：372523-75-6	TCS-OX2-29 is a potent,high affinities and selective orexin-2 receptor(OX2R) antagonist with an IC50 value of 40nM and a pKI value of 7.5.TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1.	price>
R-R-3488	Vortioxetine-d8 hydrobromide	Vortioxetine-d8 (hydrobromide) is the deuterium labeled Vortioxetine hydrobromide. Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-C-1789	Scriptaid (GCK 1026) CAS：287383-59-9	Scriptaid is a potent histone deacetylase(HDAC)inhibitor,used in cancer research.Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus(EBV)-associated lymphomas treatment.	price>
R-R-3489	LE 300 CAS No.274694-98-3	LE 300/CAS No.274694-98-3 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay.	price>
R-C-1790	S0859 CAS：1019331-10-2	S0859,an N-cyanosulphonamide compound,reversibly inhibit NBC-mediated pH(i) recovery(K(i)=1.7 microM,full inhibition at approximately 30 microM).	price>
R-R-3490	Rizatriptan-d6 benzoate CAS No.1216984-85-8	Rizatriptan-d6 (benzoate)/CAS No.1216984-85-8 is the deuterium labeled Rizatriptan benzoate. Rizatriptan benzoate is a 5-HT1 agonist triptan agent for the treatment of migraine headaches.	price>

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