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Catalog	name	Description	price
R-R-3533	Rolofylline CAS No.136199-02-5	Rolofylline (KW-3902)/CAS No.136199-02-5 is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.	price>
R-GNPLA0501-X	Gold nanorods, AuNRs-PEG-PLA	Gold Nanoparticles,polyethylene glycol poly(L-lactide) function,cas7440-57-5	price>
R-C-1834	BV6 CAS:1001600-56-1	BV6 is an inhibitor of apoptosis(IAP)proteins.It acts by promoting glioblastoma cancer stem-like cell differentiation by activating NF-κB.	price>
R-R-3534	Taminadenant CAS No.1337962-47-6	Taminadenant (NIR178; PBF509)/CAS No.1337962-47-6 is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response.	price>
R-GNPCL0401-X	Gold nanorods, AuNRs-PEG-PCL	Gold nanorods, polyethylene glycol poly(caprolactone) function, cas7440-57-5	price>
R-C-1835	MM-102 CAS:1417329-24-8	MM-102(HMTase Inhibitor IX)is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4μM in a cell-free assay.	price>
R-R-3535	Doxofylline CAS No.69975-86-6	Doxofylline/CAS No.69975-86-6 is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm.	price>
R-GNPEI0405-X	Gold nanorods, AuNRs-PEG-PEI	Gold nanorods, polyethylene glycol polyetherimide function, cas7440-57-5	price>
R-C-1836	ULM-1(MDK7526HCL) CAS:228544-65-8	VULM-1457 is an Acyl-CoA cholesterol acyltransferase(ACAT)inhibitor.	price>
R-R-3536	GS-6201 CAS No.752222-83-6	GS-6201 (CVT-6883)/CAS No.752222-83-6 is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM). GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse. GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice.	price>
R-C-1837	ZINC00881524 (ROCK inhibitor) CAS:557782-81-7	ZINC00881524 is a potent and selective ROCK inhibitor.Clinically,inhibition of ROCK pathway is believed to contribute to some of the cardiovascular benefits of statin therapy that are independent of lipid lowering(ie,pleiotropic effects).	price>
R-R-3537	LAS101057 CAS No.925676-48-8	LAS101057/CAS No.925676-48-8 is a potent, selective, and orally efficacious A2B receptor antagonist.	price>
R-C-1838	VH298 CAS:2097381-85-4	VH298 is a potent VHL(Von Hippel-Lindau,the E3 ligase)inhibitor that stabilizes HIF-α.VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry(ITC)and 80 nM in a competitive fluorescence polarization assay.VH-298 can be used in PROTAC technology.	price>
R-R-3538	Tozadenant CAS No.870070-55-6	Tozadenant/CAS No.870070-55-6 is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.	price>
R-C-1839	VCMMAE CAS:646502-53-6	VcMMAE(mc-vc-PAB-MMAE),a MMAE derivative with valine-citrulline(Vc)linker,is an antibody-drug conjugate(ADC)with potent antitumor activity.MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity.	price>
R-R-3539	N6-Ethyladenosine CAS No.14357-08-5	N6-Ethyladenosine/CAS No.14357-08-5 is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively.	price>
R-C-1840	SC-560 CAS：188817-13-2	SC-560 is a highly selective COX-1 inhibitor with IC50 of 9nM,compared with the IC50 of 6.3μM for COX-2,nearly 1,000-fold higher than with COX-1.	price>
R-R-3540	N6-(2-Phenylethyl)adenosine CAS No.20125-39-7	N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine)/CAS No.20125-39-7, an adenosine derivative, is a potent adenosine receptors (AR) agonist with Ki values of 11.8 nM, 30.1 nM, 0.63 nM for rat A1AR, human A1AR and hA3AR, respectively.	price>
R-C-1841	Belizatinib (TSR011) CAS：1357920-84-3	Belizatinib is an oral,dual,potent inhibitor of ALK and TRKA,TRKB,and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.	price>
R-R-3541	DPTN dihydrochloride CAS No.325767-87-1	DPTN/CAS No.325767-87-1 is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively.	price>

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