Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-1862	NG25 CAS:1315355-93-1	NG-25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1.It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK,FER,and p38.NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells.It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097,respectively.NG 25 decreases cell viability of HCT116KRASWT,and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner.It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12D mouse orthotopic model of colorectal cancer.	price>
R-R-3562	Tecadenoson CAS No.204512-90-3	Tecadenoson (CVT-510)/CAS No.204512-90-3 is a selective A1 adenosine receptor agonist.	price>
R-C-1863	Vecabrutinib (SNS-062) CAS:1510829-06-7	Vecabrutinib(SNS-062)is a potent,noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2nM,respectively.Vecabrutinib shows an IC50 of 24 nM for ITK.	price>
R-R-3563	CV1808 CAS No.53296-10-9	CV1808 (2-Phenylaminoadenosine)/CAS No.53296-10-9 is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.	price>
R-C-1864	BAY 61-3606 CAS:732983-37-8	BAY 61-3606 is an orally available,ATP-competitive,reversible and highly selective Syk inhibitor with a Ki of 7.5nM and an IC50 of 10nM.BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell.BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates.Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.	price>
R-R-3564	FR194921 CAS No.202646-80-8	FR194921/CAS No.202646-80-8 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with Ki value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity.	price>
R-C-1865	Takinib CAS:1111556-37-6	Takinib(EDHS-206)is a potent and selective TAK1 inhibitor with an IC50 of 9.5 nM,more than 1.5 log more potent than the second and third ranked targets,IRAK4(120 nM)and IRAK1(390 nM),respectively.Takinib induces apoptosis.	price>
R-R-3565	HEMADO CAS No.403842-38-6	HEMADO/CAS No.403842-38-6 is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1866	BAY1895344 CAS:1876467-74-1	Elimusertib(BAY-1895344)is a very potent and highly selective ATR(ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7nM Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78nM.	price>
R-R-3566	MRE3008F20 CAS No.252979-43-4	MRE3008F20/CAS No.252979-43-4 is a highly potent and selective adenosine A3 receptor (AA3R) antagonist that inhibits agonist-induced cAMP elevation in resting T cells with an IC50 of 5 nM.	price>
R-C-1867	JNJ-46778212(VU 0409551) CAS:1363281-27-9	JNJ-46778212(VU 0409551)is an mGlu5 positive allosteric modulator with an EC50 of 260nM.	price>
R-R-3567	VUF-5574 CAS No.280570-45-8	VUF-5574/CAS No.280570-45-8 is a selective antagonist of adenosine A3 receptor with a Ki of 4.03 nM for the recombinant human receptor.	price>
R-C-1868	PRT-060318(PRT318) CAS:1194961-19-7	PRT-060318(PRT318)is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4nM.	price>
R-R-3568	Enprofylline CAS No.41078-02-8	Enprofylline/CAS No.41078-02-8 acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease.	price>
R-C-1869	3-TYP CAS:120241-79-4	3-TYP is a selective SIRT3 inhibitor,with an IC50 of 16 nM,more potent over SIRT1(IC50=88nM),SIRT2(IC50=92nM).	price>
R-R-3569	KI-7 CAS No.1489263-00-4	KI-7/CAS No.1489263-00-4 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively.	price>
R-C-1870	DDP-38003 dihydrochloride CAS:1831167-98-6	DDP-38003 dihydrochloride is an novel,orally available inhibitor of histone lysine-specific demethylase 1A(KDM1A/LSD1)with an IC50 of 84nM.	price>
R-R-3570	Doxofylline-d6 CAS No.1219805-99-8	Doxofylline-d6/CAS No.1219805-99-8 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.	price>
R-C-1871	Tropifexor (LJN452) CAS:1383816-29-2	Tropifexor(LJN452)is a novel and highly potent agonist of FXR with EC50 of 0.2 nM in HTRF assay.It shows no significant off-target activity against a broad panel of enzyme,ion channel,nuclear receptor,and GPCR(>10000-fold selectivity for FXR).	price>
R-R-3571	LUF6096 CAS No.1116652-18-6	LUF6096/CAS No.1116652-18-6, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury.	price>

562563564565566567 568569570571572