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Catalog	name	Description	price
R-R-3591	Dexmedetomidine hydrochloride CAS No.145108-58-3	Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride)/CAS No.145108-58-3 is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects.	price>
R-C-1892	Doravirine (MK-1439) CAS：1338225-97-0	Doravirine(MK-1439)is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM,5.5nM and 6.1nM against the wild type and K103N and Y181C reverse transcriptase mutants.	price>
R-C-2252	Daphnoretin CAS： 2034-69-7	Daphnoretin(Dephnoretin,Thymelol),a biologically active compound isolated from Wikstroemia indica C.A.Mey.,is a protein kinase C(PKC)activator.Daphnoretin inhibits the proliferation,invasion,and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway.	price>
R-R-3592	Dobutamine hydrochloride CAS No.49745-95-1	Dobutamine hydrochloride/CAS No.49745-95-1 is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.	price>
R-C-1893	Fostemsavir(BMS-663068) CAS：864953-29-7	Fostemsavir(BMS-663068,Rukobia),the phosphonooxymethyl prodrug of BMS626529,is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of<10nM.	price>
R-C-2253	Neferine CAS：2292-16-2	Neferine((R)-1,2-Dimethoxyaporphine),a natural component of Nelumbo nucifera, has antitumor efficiency,Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells.Neferine strongly inhibits NF-κB activation.	price>
R-R-3593	Atomoxetine hydrochloride CAS No.82248-59-7	Atomoxetine (Tomoxetine) hydrochloride/CAS No.82248-59-7 is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.	price>
R-C-1894	Nazartinib(EGF816) CAS：1508250-71-2	Nazartinib(EGF816,NVS-816)is a covalent,irreversible,mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt(L858R,ex19del)and T790M mt,with up to 60-fold selectivity over wild type(wt)EGFR in vitro.	price>
R-C-2254	LM22B-10 CAS：342777-54-2	LM22B-10 is a TrkB and TrkC agonist.LM22B-10 exhibits neurotrophic activity .	price>
R-R-3594	Terazosin hydrochloride dihydrate CAS No.70024-40-7	Terazosin hydrochloride dihydrate/CAS No.70024-40-7 is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.	price>
R-C-1895	LOXO-101（Larotrectinib） CAS：1223403-58-4	Larotrectinib(LOXO-101)is an ATP-competitive oral,selective inhibitor of the tropomyosin-related kinase(TRK)family receptors,with low nanomolar 50% inhibitory concentrations against all three isoforms(TRKA,B,and C).	price>
R-C-2255	Amarogentin CAS：21018-84-8	Amarogentin(AG),a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots,exhibits anti-oxidative,anti-tumour,and anti-diabetic activities.Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α.Amarogentin induces apoptosis in human gastric cancer cells(SNU-16)through G2/M cell cycle arrest and PI3K/Akt signalling pathway.	price>
R-R-3595	Clonidine CAS No.4205-90-7	Clonidine/CAS No.4205-90-7 is an alpha 2-adrenergic agonist.	price>
R-C-1896	Glecaprevir CAS：1365970-03-1	Glecaprevir(ABT-493,A-1282576)is a novel HCV NS3/4A protease inhibitor,with IC50 values ranging from 3.5 to 11.3nM.	price>
R-C-2256	Homosalate CAS：118-56-9	Homosalat(HMS,Homomenthyl salicylate)is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.	price>
R-R-3596	Tamsulosin CAS No.106133-20-4	Tamsulosin ((R)-(-)-YM12617 free base)/CAS No.106133-20-4 is an inhibitor of α1-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models.	price>
R-C-1897	Valbenazine CAS:1025504-45-3	Valbenazine（NBI-98854 and MT-5199)is a potent and selective VMAT2 inhibitor. NBI-98854 is effective in regulating the levels of dopamine release during nerve communication,while at the same time having minimal impact on the other monoamines.NBI-98854 is promising agent for the treatment of tardive dyskinesia.NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients.These results support the phase 3 clinical trials of NBI-98854 now underway.	price>
R-C-2257	Alobresib (GS-5829) CAS：1637771-14-2	Alobresib(GS-5829)is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc.Alobresib(GS-5829)inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways,such as BLK,AKT,ERK1/2,and MYC.Alobresib (GS-5829)also inhibits NF-κB signaling.	price>
R-R-3597	SR59230A hydrochloride CAS No.1135278-41-9	SR59230A hydrochloride/CAS No.1135278-41-9 is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.	price>
R-C-1898	AS703026 CAS：1236699-92-5	AS703026 is a novel,selective,orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.	price>

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