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Catalog	name	Description	price
R-C-2258	Ailanthone CAS：981-15-7	Ailanthone(AIL,Δ13-Dehydrochaparrinone),a natural anti-hepatocellular carcinoma (HCC)component in Ailanthus altissima,induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27.Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway.Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells.	price>
R-R-3598	Guanfacine hydrochloride CAS No.29110-48-3	Guanfacine hydrochloride/CAS No.29110-48-3 is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette syndrome and attention deficit hyperactivity disorder (ADHD).	price>
R-C-1899	C188-9 CAS：432001-19-9	C188-9(TTI 101)is a potent inhibitor of STAT3 that binds to STAT3 with high affinity(KD=4.7±0.4nM).C188-9 is well tolerated in mice,shows good oral bioavailability,and is concentrated in tumors.	price>
R-C-2259	Methyl-Hesperidin CAS：11013-97-1	Methyl Hesperidin is a flavanone glycoside(flavonoid)(C28H34O15)found abundantly in citrus fruits.Its aglycone form is called hesperetin.	price>
R-R-3599	L748337 CAS No.244192-94-7	L748337/CAS No.244192-94-7 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.	price>
R-C-1900	BD1063 HCl CAS：206996-13-6	BD1063 2HCL(BD1063 dihydrochloride)is a potent and selective sigma-1 receptor (σ1R)antagonist with Ki of 4.43nM.	price>
R-C-2260	Dinaciclib (SCH727965) CAS：779353-01-4	Dinaciclib(SCH727965,PS-095760)is a novel and potent CDK inhibitor for CDK2,CDK5,CDK1 and CDK9 with IC50 of 1nM,1nM,3nM and 4nM in cell-free assays,respectively.It also blocks thymidine(dThd)DNA incorporation.Dinaciclib induces apoptosis through the activation of caspases 8 and 9.	price>
R-R-3600	Atipamezole hydrochloride CAS No.104075-48-1	Atipamezole (MPV-1248) hydrochloride/CAS No.104075-48-1 is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.	price>
R-C-1901	SF 2523 CAS：1174428-47-7	SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM,158nM,9nM,241nM and 280nM for PI3Kα,PI3Kγ,DNA-PK,BRD4 and mTOR, respectively.	price>
R-C-2261	Flavopiridol (L86-8275) CAS：146426-40-6	Flavopiridol(L86-8275,Alvocidib,NSC 649890,HMR-1275)competes with ATP to inhibit CDKs including CDK1,CDK2,CDK4,CDK6,and CDK9 with IC50 values in the 20-100nM range.It is more selective for CDK1,2,4,6,9 versus CDK7.Flavopiridol is initially found to inhibit EGFR and PKA.Flavopiridol induces autophagy and ER stress.Flavopiridol blocks HIV-1 replication.	price>
R-R-3601	Pronethalol CAS No.54-80-8	Pronethalol ((±)-Pronethalo)/CAS No.54-80-8 is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs).	price>
R-C-1902	Monastrol CAS：329689-23-8	Monastrol((±)-Monastrol)is a cell-permeable small molecule inhibitor of kinesin-5(KIF11)which is essential for maintaining separation of the half-spindles.	price>
R-C-2262	LY3405105 CAS：2326428-25-3	LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8nM.LY3405105 shows potential antineoplastic activity.	price>
R-R-3602	Metoprolol succinate CAS No.98418-47-4	Metoprolol succinate/CAS No.98418-47-4 is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties.	price>
R-C-1903	TC-G-1008 (GPR39-C3) CAS：1621175-65-2	TC-G-1008 is a GPR39(zinc receptor)agonist(EC50 values are 0.4 and 0.8nM for rat and human receptors respectively).	price>
R-C-2263	BSJ-4-116 CAS：2519823-34-6	BSJ-4-116 is a highly potent and selective CDK12 degrader(PROTAC)with an IC50 of 6 nM.BSJ-4-116 downregulates DDR genes through a premature termination of transcription,primarily through increasing poly(adenylation).BSJ-4-116 exhibits potent antiproliferative effects,alone and in combination with the poly(ADP-ribose)polymerase inhibitor Olaparib(HY-10162).	price>
R-R-3603	Guanabenz hydrochloride CAS No.23113-43-1	Guanabenz hydrochloride/CAS No.23113-43-1 is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure.	price>
R-C-1904	M2I-1 CAS：312271-03-7	M2I-1 is an inhibitor of Mad2(mitotic arrest deficient 2)targeting the binding of Mad2 to Cdc20,an essential protein-protein interaction(PPI)within the SAC(spindle assembly checkpoint).	price>
R-C-2264	CC-671 CAS：1618658-88-0	CC-671 is a dual TTK protein kinase/CDC2-like kinase(CLK2)inhibitor with IC50s of 0.005 and 0.006μM for TTK and CLK2,respectively.	price>
R-R-3604	BI-167107 CAS No.1202235-68-4	BI-167107/CAS No.1202235-68-4 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM.	price>

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