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Catalog	name	Description	price
R-C-1925	PF05175157 CAS：1301214-47-0	PF-05175157 is a potent and selective cetyl-CoA carboxylase(ACC)1 and 2 inhibitor with IC50 values of 27nM and 33 nM,respectively.PF-05175157 led to robust reduction of de novo lipogenesis(DNL),albeit with concomitant reductions in platelet count,which were attributed to the inhibition of fatty acid synthesis within bone marrow.PF-05175157 induced a reduction of the viral load in serum and kidney in WNV-infected mice,unveiling its therapeutic potential for the treatment of chronic kidney disease associated with persistent WNV infection.	price>
R-R-3625	Olodaterol hydrochloride CAS No.869477-96-3	Olodaterol (BI1744) hydrochloride/CAS No.869477-96-3 is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.	price>
R-C-1926	PF06291874 CAS：1393124-08- 7	PF-06291874(Glucagon receptor antagonists-4)is a highly potent and orally active glucagon receptor antagonist.It displays low in vivo clearance in both rats and dogs.	price>
R-R-3626	Bufuralol CAS No.54340-62-4	Bufuralol (Ro 3-4787)/CAS No.54340-62-4 is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.	price>
R-C-1927	Cilofexor （GS-9674) CAS：1418274-28-8	Cilofexor(GS-9674)is a potent,selective and orally active nonsteroidal FXR agonist with an EC50 of 43nM.Cilofexor has anti-inflammatory and antifibrotic effects.Cilofexor has the potential for primary sclerosing cholangitis(PSC)and nonalcoholic steatohepatitis(NASH)research.	price>
R-R-3627	Betaxolol hydrochloride CAS No.63659-19-8	Betaxolol Hydrochloride/CAS No.63659-19-8 is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.	price>
R-C-1928	Tipifarnib S enantiomer CAS：192185-71-0	Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib.Tipifarnib is a potent and specific farnesyltransferase(FTase)inhibitor with IC50 of 0.6nM.Tipifarnib S enantiomer is the less active isomer.	price>
R-R-3628	PCL electrospun membrane	PCL electrospun membrane/PCL electrospun film/Polycaprolactone electrospun membrane/Polycaprolactone electrospun film from ruixi.PCL electrospinning membrane is a polycaprolactone (PCL) nanofiber membrane prepared by electrospinning technology. PCL is a linear hydrophobic synthetic polymer with high mechanical strength and good biocompatibility, so it is widely used in fields such as drug carriers, degradable plastics, and nanofiber spinning.PCL electrospun membrane has high specific surface area, high pore removal rate and good mechanical properties. These characteristics make it an ideal choice in the fields of tissue engineering, drug delivery and wound materials, as a tissue engineering scaffold material. PCL statically spun membrane can provide a three-dimensional growth space for cells, support cell growth and differentiation, and promote tissue regeneration. As a drug delivery carrier, PCL electrospun membrane can load drugs and control the release rate of drugs, achieve targeted delivery and sustained release of drugs, improve the therapeutic effect of drugs and reduce side effects. In addition, due to its good biocompatibility and mechanical properties, PCL electrospun membrane can also be used in wound dressings to provide protection and support for wounds and promote wound healing.However, the performance and application of PCL electrospinning membranes may be affected by factors such as spinning parameters, fiber morphology and composition. Therefore, in-depth research and optimization are needed to improve the performance and application effects of PCL electrospun membranes.	price>
R-C-1929	AM966 CAS：1228690-19-4	AM966 is a high affinity,selective,oral LPA1-antagonist,inhibits LPA-stimulated intracellular calcium release(IC50=17nM).	price>
R-R-3629	PCL gelatin nanofiber membrane	PCL gelatin nanofiber membrane/Polycaprolactone gelatin nanofiber membrane from ruixi. PCL gelatin nanofiber membranes are composite materials produced through electrospinning, combining Polycaprolactone (PCL) and gelatin.Nanomaterials prepared by electrospinning can be used in various fields such as biopolymer materials, battery separators, filter materials, catalysts, sensors, etc.	price>
R-C-1930	AM095 CAS: 1228690-36-5	AM095 is a potent LPA1 receptor antagonist because it inhibited GTPγS binding to Chinese hamster ovary(CHO)cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73μM,respectively,and exhibited no LPA1 agonism.Lysophosphatidic acid(LPA)is a bioactive phospholipid that signals through a family of at least six G protein-coupled receptors designated LPA1-6. LPA type 1 receptor(LPA1)exhibits widespread tissue distribution and regulates a variety of physiological and pathological cellular functions.	price>
R-R-3630	PCL hyaluronic acid nanofiber membrane	PCL hyaluronic acid nanofiber membrane/Polycaprolactone hyaluronic acid nanofiber membrane from ruixi.PCL hyaluronic acid nanofiber membranes are composite materials produced through the electrospinning process, integrating Polycaprolactone (PCL) and hyaluronic acid. The tailored properties of PCL hyaluronic acid nanofiber membranes make them suitable for a wide range of potential biomedical applications, such as wound dressings, drug delivery systems, and scaffolds for tissue engineering. The ability to modify the physical characteristics of the membrane, including pore size, porosity, and degradation kinetics, through adjusting the electrospinning parameters makes it highly versatile for specific tissue engineering requirements.	price>
R-C-1931	EHT5372 CAS :1425945-63-6	EHT 5372 is a highly potent and selective inhibitor of DYRK isfamily kinases with IC50s of 0.22,0.28,10.8,93.2,22.8,88.8,59.0,7.44,221 nM for DYRK1A,DYRK1B,DYRK2,DYRK3,CLK1,CLK2,CLK4,GSK-3α,GSK-3β.	price>
R-R-3631	PCL silk fibroin nanofiber membrane	PCL silk fibroin nanofiber membrane/Polycaprolactone silk fibroin nanofiber membrane from ruixi.PCL silk fibroin nanofiber membrane is a nanofiber membrane material that combines polycaprolactone (PCL) and silk fibroin. As a biodegradable polyester, PCL has good mechanical properties and biocompatibility, while silk fibroin is a natural polymer protein with good biological activity and mechanical properties. Combining PCL and silk fibroin to form a nanofiber membrane can combine the advantages of both and improve the biocompatibility, mechanical properties and functionality of the material. Pcl silk fibroin nanofiber membranes are also usually prepared by electrospinning. By controlling the spinning parameters, fibers with nanometer diameters can be obtained. This fiber membrane material has high specific surface area, high porosity and good biological activity, so it can be used in tissue engineering, wound dressings, drug delivery and biosensors. In addition, due to the good biocompatibility and biological activity of silk fibroin, the Pcl silk fibroin nanofiber membrane can also promote cell adhesion and proliferation, thereby promoting tissue regeneration and repair. Therefore, this material has broad application prospects in the biomedical field.	price>
R-C-1932	Verubecestat (MK-8931)	Verubecestat(MK-8931)is an orally active,high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2nM and 0.38nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer is Disease.	price>
R-R-3632	PCL silk fibroin electrospun membrane	PCL silk fibroin electrospun membrane/Polycaprolactone silk fibroin electrospun membrane from ruixi. PCL silk fibroin electrospun membranes are composite materials created through the electrospinning process, combining Polycaprolactone (PCL) and silk fibroin. PCL silk fibroin electrospun membranes represent an exciting and promising material for tissue engineering, regenerative medicine, and related biomedical fields, given their ability to provide a biomimetic microenvironment that supports cell growth and tissue regeneration. This particular combination of materials opens up new avenues for advancing biomedical research and clinical applications.	price>
R-C-1933	ALVELESTAT (AZD 9668) CAS:848141-11-7	Alvelestat(AZD9668,Avelestat)is an oral,highly selective inhibitor of neutrophil elastase(NE)with IC50 and Ki of 12nM and 9.4nM,at least 600-fold more selective over other serine proteases.	price>
R-R-3633	PLA/gelatin electrospun nanofiber membrane	Polylactic acid/gelatin electrospun nanofiber membrane is a nanofiber membrane material that combines polylactic acid (PLA) and gelatin. Polylactic acid is a biodegradable polymer material with good mechanical properties and biocompatibility; gelatin is a natural polymer material derived from animal bones and skin and other tissues, and has good biological activity and adhesion. Through electrospinning technology, polylactic acid and gelatin can be combined to form a nanoscale fiber membrane. This membrane material combines the advantages of both and shows better performance and application prospects.Polylactic acid (gelatin) electrospun nanofiber membrane has high specific surface area, high porosity and good biological activity, so it can provide a good environment for cell growth and material transmission, promote cell adhesion and proliferation, in addition, due to the adhesiveness of gelatin This kind of fiber membrane also has good adhesion properties and can closely adhere to the tissue surface, helping to repair and regenerate the tissue. In the field of tissue engineering, polylactic acid/gelatin electrospinning nanofiber membrane can be used as a scaffold material, supports the growth and differentiation of cells, and promotes tissue regeneration and repair. At the same time, due to the biodegradability of polylactic acid, this fiber membrane material can be gradually degraded and absorbed in the body, avoiding the need for secondary surgical removal. In addition , polylactic acid/gelatin electrospun nanofiber membranes can also be used in fields such as drug delivery, wound dressings and biosensors. By loading bioactive substances such as drugs or growth factors, sustained release and targeted delivery of drugs can be achieved, improving drug delivery. therapeutic effect and reduce side effects.	price>
R-C-1934	BAY 80-6946 CAS:1032568-63-0	Copanlisib(BAY80-6946)is a potent,selective and ATP-competitive pan-class I PI3K inhibitor,with IC50s of 0.5nM,0.7nM,3.7nM and 6.4nM for PI3Kα,PI3Kδ,PI3Kβ and PI3Kγ,respectively.Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases,except for mTOR. Copanlisib has superior antitumor activity.	price>
R-R-3634	PLGA composite silk fibroin electrospun fiber membrane	PLGA composite silk fibroin electrospun fiber membrane/Poly(lactic-co-glycolic acid) composite silk fibroin electrospun fiber membrane from ruixi. PLGA composite silk fibroin electrospun fiber membrane is an electrospun fiber membrane material that combines Poly(lactic-co-glycolic acid) (PLGA) and silk fibroin. PLGA is a biodegradable polyester with good mechanical properties and biocompatibility, while silk fibroin is a natural polymer protein with good biological activity and mechanical properties. Through electrospinning technology, PLGA and silk fibroin can be combined to form nanoscale fiber membranes with high specific surface area and porosity, providing a good environment for cell growth and material transmission. PLGA composite silk fibroin electrospun fiber membrane has broad application prospects in the biomedical field, such as tissue engineering, drug delivery, wound dressings, etc. Its good biocompatibility and mechanical properties can promote cell adhesion and proliferation, thereby promoting tissue regeneration and repair. At the same time, the biodegradability of PLGA allows this fiber membrane material to be gradually degraded and absorbed in the body, avoiding the need for secondary surgical removal. In addition, the PLGA composite silk fibroin electrospun fiber membrane can also be adjusted by adjusting spinning parameters and adding Growth factors and other methods are modified to improve its performance and functionality. For example, bioactive substances such as growth factors can be added to promote cell differentiation and functional expression.	price>

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