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Catalog	name	Description	price
R-R-3913	Amosulalol CAS No.85320-68-9	Amosulalol (YM 09538)/CAS No.85320-68-9 is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR).	price>
R-C-2214	SKLB 610 CAS:1125780-41-7	SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2,fibroblast growth factor receptor 2(FGFR2)and platelet-derived growth factor receptor(PDGFR)at rate of 97%,65% and 55%,respectively,at concentration of 10μM in biochemical kinase assays.SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity.	price>
R-R-3914	Yohimbine-13C,d3 CAS No.1261254-59-4	Yohimbine-13C,d3/CAS No.1261254-59-4 is the 13C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.	price>
R-C-2215	MAZ51 CAS:163655-37-6	MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor(VEGFR)-3(Flt-4)tyrosine kinase.MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA.MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.	price>
R-R-3915	Upidosin CAS No.152735-23-4	Upidosin (Rec 15/2739)/CAS No.152735-23-4 is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a Kb value of 2-3 nM higher than in ear artery and aorta with a Kb value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction.	price>
R-C-2216	SU5204 CAS:186611-11-0	SU5204,a tyrosine kinase inhibitor,has IC50s of 4 and 51.5μM for FLK-1(VEGFR-2)and HER2,respectively.	price>
R-R-3916	4-Hydroxyatomoxetine-d3 CAS No.1217686-14-0	4-Hydroxyatomoxetine-d3/CAS No.1217686-14-0 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor.	price>
R-C-2217	AUNP-12 CAS:1353563-85-5	AUNP-12(NP-12)is a peptide antagonist of the PD-1 signaling pathway,displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions.	price>
R-R-3917	Bambuterol-d9 hydrochloride CAS No.1794810-59-5	Bambuterol-d9 (hydrochloride)/CAS No.1794810-59-5 is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.	price>
R-C-2218	BMS-1166 CAS:1818314-88-3	BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor.BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1,with an IC50 of 1.4 nM.BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.	price>
R-R-3918	Abanoquil CAS No.90402-40-7	Abanoquil (U-K52046)/CAS No.90402-40-7, an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research.	price>
R-C-2219	BMS-1001 CAS: 2113650-03-4	BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253nM.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.	price>
R-R-3919	Ivabradine-d6 hydrochloride CAS No.2070009-63-9	Ivabradine-d6 (hydrochloride)/CAS No.2070009-63-9 is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.	price>
R-C-2220	Durvalumab (anti-PD-L1) CAS:1428935-60-7	Durvalumab(MEDI 4736)is an humanized anti-PD-L1 monoclonal antibody.Durvalumab (MEDI4736)completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04nM,respectively.	price>
R-R-3920	N-(Phenylacetyl-d5)glycine CAS No.1189920-31-7	N-(Phenylacetyl-d5)glycine/CAS No.1189920-31-7 is the deuterium labeled Phenylacetylglycine. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.	price>
R-C-2221	TCPOBOP CAS:76150-91-9	TCPOBOP is an agonist of the constitutive androstane receptor(CAR)(EC50=20nM). TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP),as dose-dependent direct agonist of CAR.	price>
R-R-3921	Tetrahydroalstonine CAS No.6474-90-4	Tetrahydroalstonine/CAS No.6474-90-4, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist.	price>
R-C-2222	Marinopyrrole A (Maritoclax) CAS:1227962-62-0	Marinopyrrole A(Maritoclax)is a selective Mcl-1 antagonist.It binds to Mcl-1,but not Bcl-XL,and targets Mcl-1 for proteasomal degradation.Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1μM.	price>
R-R-3922	Tulobuterol-d9 hydrochloride CAS No.1325559-14-5	Tulobuterol-d9 (hydrochloride)/CAS No.1325559-14-5 is the deuterium labeled Tulobuterol. Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.	price>
R-C-2223	Obatoclax Mesylate (GX15-070) CAS: 803712-79-0	Obatoclax Mesylate(GX15-070 Mesylate),a BH3 mimetic,is a pan-BCL-2 family proteins inhibitor with a Ki of 220nM for BCL-2.Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation.Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity.	price>

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