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Catalog	name	Description	price
R-C-2281	Go6976 CAS:136194-77-9	Go6976 is a potent PKC inhibitor with IC50 of 7.9nM,2.3nM,and 6.2nM for PKC(Rat brain),PKCα,and PKCβ1,respectively.Also a potent inhibitor of JAK2 and Flt3.	price>
R-R-3981	Guanfacine-13C,15N3 CAS No.1189924-28-4	Guanfacine-13C,15N3/CAS No.1189924-28-4 is the 13C and 15N labeled Guanfacine. Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation.	price>
R-C-2282	Pomalidomide (CC-4047) CAS:19171-19-8	Pomalidomide,the third-generation immunomodulatory agent,acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.	price>
R-R-3982	Talibegron hydrochloride CAS No.178600-17-4	Talibegron hydrochloride (ZD2079 hydrochloride)/CAS No.178600-17-4 is a potent β3-adrenoceptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect.	price>
R-C-2283	CC-90009 CAS:1860875-51-9	CC-90009 is a cereblon modulator.CC-90009 specifically binds to CRBN,thereby affecting the activity of the ubiquitin E3 ligase complex.This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors,including Ikaros(IKZF1)and Aiolos (IKZF3),which are transcriptional repressors in T-cells.This reduces the levels of these transcription factors,and modulates the activity of the immune system, which may include the activation of T-lymphocytes.	price>
R-R-3983	Perphenazine-d8 dihydrochloride CAS No.2070015-23-3	Perphenazine-d8 (dihydrochloride)/CAS No.2070015-23-3 is the deuterium labeled Perphenazine, which is a typical antipsychotic agent(5-HT, Dopamine receptor ligand).	price>
R-C-2284	SZL P1-41 CAS: 222716-34-9	SZL P1-41(compound #25)is a specific inhibitor of S-phase kinase-associated protein 2(Skp2)that indeed binds to Skp2,prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity,which consequently suppresses survival of cancer cells and cancer stem cells.SZL P1-41 causes higher apoptosis rates in cancer cells.	price>
R-R-3984	Phentolamine-d4 hydrochloride CAS No.1346599-65-2	Phentolamine-d4 (hydrochloride)/CAS No.1346599-65-2 is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction.	price>
R-C-2285	Xevinapant (AT406) CAS:1071992-99-8	Xevinapant(AT406,ARRY-334543,Debio1143,SM-406)is a potent Smac mimetic and an antagonist of IAP(inhibitor of apoptosis protein via E3 ubiquitin ligase),binding to XIAP-BIR3,cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4nM,1.9 nM,and 5.1nM,50-to 100-fold higher affinities than the Smac AVPI peptide.	price>
R-R-3985	Silodosin-d4 CAS No.1426173-86-5	Silodosin-d4/CAS No.1426173-86-5 is the deuterium labeled Silodosin. Silodosin (KAD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH.	price>
R-R-3986	OPC-28326 CAS No.167626-17-7	OPC-28326/CAS No.167626-17-7 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.	price>
R-R-3987	Esmolol-d7 hydrochloride CAS No.1346598-13-7	Esmolol-d7 (hydrochloride)/CAS No.1346598-13-7 is the deuterium labeled Esmolol hydrochloride. Esmolol hydrochloride is a beta adrenergic receptor blocker.	price>
R-R-3988	Dronedarone-d6 hydrochloride CAS No.1329809-23-5	Dronedarone-d6 (hydrochloride)/CAS No.1329809-23-5 is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4.	price>
R-R-3989	Midaglizole hydrochloride CAS No.79689-25-1	Midaglizole hydrochloride (DG5128)/CAS No.79689-25-1 is a preferential α2-adrenoceptor antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor.	price>
R-C-2290	NSC 207895 CAS:58131-57-0	NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7,LNCaP,and A549 cells(1 to 10µM for 16 to 24h)by suppressesing MDMX promoter transcription activity(IC50=2.5µM in HT1080 cells),leading to enhanced p53 stabilization and activation.	price>
R-R-3990	Tranilast CAS No.53902-12-8	Tranilast (MK-341)/CAS No.53902-12-8 acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells.	price>
R-C-2291	CC-885 CAS:1010100-07-8	CC-885 is a potent Cereblon Modulator with potent antitumor activity mediated through the degradation of GSPT1.was demonstrated to mediate antitumor effects through the recruitment and degradation of G1 to S phase transition 1 protein (GSPT1).GSPT1(also named eRF3a)is a translation termination factor that binds eukaryotic translation termination factor 1(eFR1)to mediate stop codon recognition and nascent protein release from the ribosome.	price>
R-R-3991	Valsartan CAS No.137862-53-4	Valsartan (CGP 48933)/CAS No.137862-53-4 is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.	price>
R-C-2292	Mezigdomide (CC-92480) CAS:2259648-80-9	CC-92480,a cereblon E3 ubiquitin ligase modulating drug(CELMoD),acts as a molecular glue.CC-92480 shows high affinity to cereblon,resulting in potent antimyeloma activity.	price>
R-R-3992	Talfirastide CAS No.51833-78-4	Angiotensin 1-7 (Ang-(1-7))/CAS No.51833-78-4 is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .	price>

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