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Catalog	name	Description	price
R-R-4052	CMF019 CAS No.1586787-08-7	CMF019/CAS No.1586787-08-7 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin.	price>
R-C-2353	Hygromycin B CAS:31282-04-9	Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus.It acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote,with the potency to inhibit translation.	price>
R-R-4053	MM 07 CAS No.1876450-21-3	MM 07/CAS No.1876450-21-3 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.	price>
R-C-2354	Pyrazinamide CAS:98-96-4	Pyrazinamide(Pyrazinecarboxamide;Pyrazinoic acid amide)is a potent and orally active antitubercular antibiotic.Pyrazinamide is a prodrug that is converted to the active form pyrazinoic acid(POA)by PZase/nicotinamidase encoded by the pncA gene in M.tuberculosis.	price>
R-R-4054	Apelin-17(human, bovine) CAS No.217082-57-0	Apelin-17(human, bovine)/CAS No.217082-57-0 is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ.	price>
R-C-2355	Bacitracin Zinc CAS:1405-89-6	Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate,a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane.It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10μM.	price>
R-R-4055	MM 54 CAS No.1313027-43-8	MM 54 (compound 5)/CAS No.1313027-43-8 is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation.	price>
R-C-2356	Sulfameter CAS:651-06-9	Sulfametoxydiazine(INN)or sulfamethoxydiazine(USAN:sulfameter)is a long-acting sulfonamide antibacterial.It is used as a leprostatic agent and in the treatment of urinary tract infections.	price>
R-R-4056	ML233 CAS No.2080311-92-6	ML233/CAS No.2080311-92-6 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM).	price>
R-C-2357	Protionamide CAS:14222-60-7	Protionamide(or prothionamide)is a drug used in the treatment of tuberculosis; has also been tested for use in the treatment of leprosy.Target:Anti tuberculosisAlthough ETH and PTH are both potent drugs against M.tuberculosis (MIC=～0.5μg/ml)(24),they do not affect E.coli growth,even at very high concentrations(100μg/ml),which is primarily caused by the absence of an EthA homologue in E.coli.	price>
R-R-4057	Apelin-36(rat, mouse) CAS No.230299-95-3	Apelin-36(rat, mouse)/CAS No.230299-95-3 is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM. Apelin-36(rat, mouse) blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.	price>
R-C-2358	Taxifolin 7-O-rhamnoside	Taxifolin 7-O-rhamnoside(Taxifolin 7-O-α-L-rhamnoside)is a flavonoid isolated from Hypericum japonicum.	price>
R-R-4058	Bombesin CAS No.31362-50-2	Bombesin/CAS No.31362-50-2, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors.	price>
R-C-2359	Steviolbioside CAS:41093-60-1	Steviolbioside is a rare sweetener that exists in stevia rebaudiana leaves. Steviolbioside presents inhibition on several human cancer cells and acts as potential remedy for human breast cancer.	price>
R-R-4059	PD176252 CAS No.204067-01-6	PD176252/CAS No.204067-01-6 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.	price>
R-C-2360	KKL-10 CAS:952849-76-2	KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.	price>
R-R-4060	MK-5046 CAS No.1022152-70-0	MK-5046/CAS No.1022152-70-0 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity.	price>
R-C-2361	Auranofin CAS:34031-32-8	Auranofin (Ridaura,SKF-39162)is an inhibitor of thioredoxin reductase(TrxR)with IC50 of 88 nM for purified H.pylori TrxR in cell-free assay.Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2μM.	price>
R-R-4061	RC-3095 TFA CAS No.1217463-61-0	RC-3095 TFA/CAS No.1217463-61-0 is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice.	price>
R-C-2362	Aminothiazole CAS:96-50-4	Aminothiazole(2-Aminothiazole),a typical heterocyclic amine,is a precursor for the synthesis of biologically active molecules including sulfur agents,biocides, fungicides,antibiotics,dyes and chemical reaction accelerators.	price>

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