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Catalog	name	Description	price
R-C-2451	Ivermectin (MK-933) CAS： 70288-86-7	Ivermectin(MK-933)is a broad-spectrum anti-parasite agent.Ivermectin(MK-933)is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus.It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor(nAChRs).Ivermectin also inhibits bovine herpesvirus1(BoHV-1)replication and inhibits BoHV-1 DNA polymerase nuclear import.Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19.	price>
R-R-4151	RS 504393 CAS No.300816-15-3	RS 504393/CAS No.300816-15-3 is a selective CCR2 chemokine receptor antagonist (IC50 values are 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively).	price>
R-C-2452	PNU-120596 CAS：501925-31-1	PNU-120596(NSC 216666)is a potent and selective α7 nAChR positive allosteric modulator(PMA)with an EC50 of 216 nM.PNU-120596 is inactive against α4β2, α3β4,and α9α10 nAChRs.PNU-120596 has the potential for psychiatric and neurological disorders research.	price>
R-R-4152	Bindarit CAS No.130641-38-2	Bindarit (AF2838)/CAS No.130641-38-2 is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity.	price>
R-C-2453	BNC210 CAS：13589-06-5	BNC210(H-Ile-Trp-OH;IW-2143)is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.	price>
R-R-4153	INCB3344 CAS No.1262238-11-8	INCB3344/CAS No.1262238-11-8 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.	price>
R-C-2454	VU0238441 CAS：85511-68-8	VU0238441 is a pan muscarinic acetylcholine receptor(mAChR)positive allosteric modulator(PAM)with EC50s of 3.2 μM,2.8μM,2.2μM,2.1μM,>10μM for M1,M2,M3,M5 and M4,respectively.	price>
R-R-4154	Ilacirnon CAS No.1100318-47-5	CCX140 (CCX140-B)/CAS No.1100318-47-5 is a potent CCR2 antagonist.	price>
R-C-2455	VU0119498 CAS：79183-37-2	VU0119498 is a pan Gq mAChR M1,M3,M5 positive allosteric modulator(PAM), with EC50s of 6.04,6.38,and 4.08µM,respectively.VU0119498 has antidiabetic activity.	price>
R-R-4155	(1S)-CCR2 antagonist 1 CAS No.1683534-97-5	(1S)-CCR2 antagonist 1/CAS No.1683534-97-5 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.	price>
R-C-2456	benzylquinolone carboxylic acid CAS：338747-41-4	BQCA(benzylquinolone carboxylic acid)is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor(mAChR).	price>
R-R-4156	RS102895 hydrochloride CAS No.1173022-16-6	RS102895 hydrochloride/CAS No.1173022-16-6 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.	price>
R-C-2457	VU0238429 CAS：1160247-92-6	VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5(mAChR5 or M5),with an EC50 of 1.16μM.	price>
R-R-4157	Cenicriviroc CAS No.497223-25-3	Cenicriviroc (TAK-652)/CAS No.497223-25-3 is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.	price>
R-C-2458	JHU37152 CAS：2369979-67-7	JHU37152 is a potent and brain-penetrant DREADD agonist,with EC50s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells,respectively. JHU37152 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.	price>
R-R-4158	TAK-779 CAS No.229005-80-5	TAK-779/CAS No.229005-80-5 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.	price>
R-C-2459	JHU37160 CAS：2369979-68-8	JHU37160 is a potent and brain-penetrant DREADD agonist,with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells,respectively.JHU37160 exhibits selective Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.	price>
R-R-4159	Zelnecirnon CAS No.2366152-15-8	Zelnecirnon (RPT193)/CAS No.2366152-15-8 is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research.	price>
R-C-2460	Varenicline Tartrate (CP 526555-18) CAS：375815-87-5	Varenicline Tartrate(CP 526555;Champix)is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.	price>
R-R-4160	CCR6 antagonist 1 CAS No.588674-64-0	CCR6 antagonist 1/CAS No.588674-64-0 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs).	price>

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