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Catalog	name	Description	price
R-C-2563	STATTIC CAS：19983-44-9	Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation(at Y705 and S727).Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3.Stattic ameliorates the renal dysfunction in Alport syndrome (AS)mice.	price>
R-R-4263	CXCR2 antagonist 8 CAS No.182498-30-2	CXCR2 antagonist 8/CAS No.182498-30-2 is a potent and selective CXCR2 antagonist. CXCR2 antagonist 8 can be used for insulin resistance research.	price>
R-C-2564	Belumosudil (KD025, SLx-2119) CAS：911417-87-3	Belumosudil(KD025)is a selective inhibitor of ROCK2 with IC50s of 105nM and 24 µM for ROCK2 and ROCK1,respectively.Anti-fibrotic properties.	price>
R-R-4264	CXCR7 antagonist-1 hydrochloride CAS No.2990472-61-0	CXCR7 antagonist-1 hydrochloride/CAS No.2990472-61-0 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128).	price>
R-C-2565	MDK83190 CAS：79183-19-0	MDK83190 is a potent apoptosis activator,induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner.	price>
R-R-4265	Ladarixin sodium CAS No.865625-56-5	Ladarixin sodium (DF 2156A)/CAS No.865625-56-5 is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin sodium can be used for the research of COPD and asthma.	price>
R-C-2566	IDF-11774 CAS:1429054-28-3	IDF-11774 is a hypoxia-inducible factor-1(HIF-1)inhibitor.It reduces the HRE-luciferase activity of HIF-1α(IC50=3.65μM)and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.	price>
R-R-4266	ATI-2341 TFA	ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs).	price>
R-R-4267	USL311 CAS No.1373268-67-7	USL311/CAS No.1373268-67-7 is a potent and selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4.	price>
R-R-4268	CXCR2-IN-2 CAS No.1838123-21-9	CXCR2-IN-2/CAS No.1838123-21-9 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM.	price>
R-R-4269	Ulocuplumab CAS No.1375830-34-4	Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338)/CAS No.1375830-34-4 is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models.	price>
R-C-2570	Zotarolimus CAS:221877-54-9	Zotarolimus(ABT-578)is a derivative of rapamycin(HY-10219),with anti-proliferative activity.Zotarolimus is an immunosuppressant.Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis.	price>
R-R-4270	SRT3190 CAS No.1204707-73-2	SRT3190/CAS No.1204707-73-2 is an antagonist of CXCR2, used in the research of chemokine mediated diseases.	price>
R-C-2571	Carmoisine CAS:154-93-8	Carmustine(bis-chloroethylnitrosourea,BCNU,BiCNU)is a cell-cycle phase nonspecific alkylating antineoplastic agent and used in the treatment of brain tumors and various other malignant neoplasms.	price>
R-R-4271	ALX 40-4C Trifluoroacetate	ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.	price>
R-C-2572	Metolazone CAS:17560-51-9	Metolazone(SR-720-22)is primarily used to treat congestive heart failure and high blood pressure.	price>
R-R-4272	CTCE-9908 CAS No.1030384-98-5	CTCE-9908/CAS No.1030384-98-5 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells.	price>
R-C-2573	Delanzomib (CEP-18770) CAS:847499-27-8	Delanzomib(CEP-18770)is a potent and orally active chymotrypsin-like activity of the proteasome inhibitor with an IC50 of 3.8nM.Delanzomib inhibits NF-κB activity,induces cancer cell apoptotic,and has strong antiangiogenic and anti-cancer activities.	price>
R-R-4273	ACT-777991 CAS No.1967811-46-6	ACT-777991/CAS No.1967811-46-6 is an orally active and selective CXCR3 antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11.	price>
R-C-2574	Trabectedin CAS:114899-77-3	Trabectedin(Ecteinascidin 743;ET-743)is a tetrahydroisoquinoline alkaloid with potent antitumor activity.Trabectedin binds to the minor groove of DNA,blocks transcription of stress-induced proteins,induces DNA backbone cleavage and cancer cells apoptosis,and increases the generation of ROS in MCF-7 and MDA-MB-453 cells.	price>

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