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Catalog	name	Description	price
R-C-2595	Betulinic acid CAS:472-15-1	Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba,the common white birch)with antiinflammatory,anti-HIV and antineoplastic activities.Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species,and opening of mitochondrial permeability transition pores,resulting in the release of mitochondrial apogenic factors, activation of caspases,and DNA fragmentation.	price>
R-R-4295	Fluphenazine dihydrochloride CAS No.146-56-5	Fluphenazine dihydrochloride/CAS No.146-56-5 is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.	price>
R-C-2596	Plumbagin CAS:481-42-5	Plumbagin,exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma;has antifungal,antiviral,and antibacterial action.	price>
R-R-4296	ONC206 CAS No.1638178-87-6	ONC206/CAS No.1638178-87-6 is an analogue of TRAIL inducer ONC201. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.	price>
R-C-2597	HLI 373 CAS:502137-98-6	HLI 373 is an inhibitor of Hdm2 ubiquitin ligase(E3)which blocks Hdm2-mediated ubiquitylation,proteasomal degradation of p53 and activates p53-dependent transcription.	price>
R-R-4297	Sulpiride CAS No.15676-16-1	Sulpiride/CAS No.15676-16-1 is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer.	price>
R-C-2598	Matrine CAS:519-02-8	Matrine,a novel autophagy inhibitor,possesses anti-inflammation, immunosuppression,anti-fibrotic and anticancer activities,it could inhibit cell proliferation and induce apoptosis of SGC-7901 cells in vitro by up-regulating Fas/FasL expression and activating caspase-3 enzyme.	price>
R-R-4298	Raclopride CAS No.84225-95-6	Raclopride/CAS No.84225-95-6 is a dopamine D2/D3 receptor antagonist with potential antipsychotic effects. Raclopride binds to D2 and D3 receptors with Kis of 1.8 nM and 3.5 nM, respectively.	price>
R-C-2599	Embelin CAS:550-24-3	Embelin(Embelic acid),a potent,nonpeptidic XIAP inhibitor(IC50=4.1μM), inhibits cell growth,induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP.Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.	price>
R-R-4299	SKF-82958 hydrobromide CAS No.74115-01-8	SKF-82958 ((±)-SKF 82958) hydrobromide/CAS No.74115-01-8 is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM).	price>
R-C-2600	NSC 66811 CAS:6964-62-1	NSC 66811 is a MDM2-p53 inhibitor,with a Ki of 120nM for binding to MDM2.	price>
R-R-4300	Dihydrexidine hydrochloride CAS No.137417-08-4	Dihydrexidine hydrochloride (DAR-0100 hydrochloride)/CAS No.137417-08-4 is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity. Dihydrexidine hydrochloride can stimulate YAP phosphorylation.	price>
R-C-2601	Mcl1-IN-1 CAS:713492-66-1	Mcl1-IN-1 is a potent and selective inhibitor of the apoptosis regulating proteins Mcl-1.	price>
R-R-4301	Tetrahydropalmatine CAS No.2934-97-6	Tetrahydropalmatine/CAS No.2934-97-6 possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.	price>
R-C-2602	NSC 319726 CAS:71555-25-4	NSC319726(ZMC1)is a mutant p53R175 reactivator;inhibits growth of fibroblasts expressing the p53R175 mutation(IC50=8nM);shows no inhibition for p53 wild-type cells.	price>
R-R-4302	Pergolide mesylate CAS No.66104-23-2	Pergolide mesylate (Pergolide methanesulfonate)/CAS No.66104-23-2, an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist.	price>
R-C-2603	MIRA-1NSC19630 CAS:72835-26-8	MIRA-1 restores wild-type conformation,function and DNA binding activity to mutant p53.Induces p53 transcriptional transactivation of p21,MDM2 and PUMA.	price>
R-R-4303	Tetrahydroberberine CAS No.522-97-4	Tetrahydroberberine/CAS No.522-97-4 is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach.	price>
R-C-2604	Brassinolide CAS:72962-43-7	Brassinolide,a plant steroid isolated from Brassica napus pollen,promotes cell elongation and cell devision and thus regulates plant growth and development.	price>
R-R-4304	Ralmitaront CAS No.2133417-13-5	Ralmitaront (RO6889450)/CAS No.2133417-13-5 is an orally active agonist of trace amine-associated receptor 1 (TAAR1) with a EC50 value of 110.4 nM. Ralmitaront has antipsychotic, cognitively improvement, and antidepressant activity in rodents. Ralmitaront can be used as a neurosuppressant in the study of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder.	price>

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