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Catalog	name	Description	price
R-C-2615	Midostaurin (PKC412) CAS:120685-11-2	Midostaurin(PKC412;CGP 41251)is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ,Syk,Flk-1,Akt,PKA,c-Kit,c-Fgr,c-Src,FLT3,PDFRβ and VEGFR1/2 with IC50s ranging from 22-500nM.	price>
R-R-4315	Clebopride malate CAS No.57645-91-7	Clebopride malate/CAS No.57645-91-7 is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders.	price>
R-C-2616	Calphostin C CAS:121263-19-2	The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.The known calphostins include calphostin A,calphostin B,calphostin C,calphostin D,and calphostin I.The calphostins are inhibitors of protein kinase C(PKC).	price>
R-R-4316	Nomifensine maleate CAS No.32795-47-4	Nomifensine maleate/CAS No.32795-47-4 is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.	price>
R-C-2617	PKC fragment (530-558)	Potent activator of protein kinase C(Ka~10 mM);corresponds to residues 530-558 of the catalytic domain of PKC.	price>
R-R-4317	Pridopidine CAS No.346688-38-8	Pridopidine/CAS No.346688-38-8, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.	price>
R-C-2618	Ro 31-8220 Mesylate CAS:138489-18-6	Ro 31-8220 is a PKC-inhibitor,which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA,IC50=1.35 x 10(-6)M)or diacylglycerols(OAG,diC8)by 95%.Ro-31-8220 showed the apoptotic effect on HL-60 cells,which was mediated by a well-characterized transduction process of apoptotic signals:i.e.,mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol.	price>
R-R-4318	Dexpramipexole dihydrochloride CAS No.104632-27-1	Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride)/CAS No.104632-27-1 is a neuroprotective agent and weak non-ergoline dopamine agonist.	price>
R-C-2619	chroman 1 CAS:1273579-40-0	Chroman 1 is a highly potent and selective ROCK II inhibitor.	price>
R-R-4319	LY3154207 CAS No.1638667-79-4	LY3154207/CAS No.1638667-79-4 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM).	price>
R-C-2620	Vactosertib (TEW-7197) CAS:1352608-82-2	Vactosertib(EW-7197)is a potent,orally active and ATP-competitive activin receptor-like kinase 5(ALK5)inhibitor with an IC50 of 12.9nM.Vactosertib also inhibits ALK2 and ALK4(IC50 of 17.3nM)at nanomolar concentrations.Vactosertib has potently antimetastatic activity and anticancer effect.	price>
R-R-4320	GSK598809 CAS No.863680-45-9	GSK598809/CAS No.863680-45-9 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9.	price>
R-C-2621	LDN-212854 CAS:1432597-26-6	LDN-212854 is a novel BMP inhibitor that exhibits substantially greater selectivity for BMP versus the TGF-β type I receptors;possesses a bias towards ALK2(IC50=1.3nM)versus ALK1 and ALK3 compared to other inhibitors.	price>
R-R-4321	L-745870 CAS No.158985-00-3	L-745870/CAS No.158985-00-3 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors.	price>
R-C-2622	CGP 53353 CAS:145915-60-2	Selective inhibitor of PKCβII(IC50 values are 0.41 and 3.8μM for PKCβII and PKCβI respectively).Also inhibits prionogenic Sup35 fibrillization (IC50~ 3.4μM)and inhibits de novo Aβ42 assembly in vitro.	price>
R-R-4322	Tiapride hydrochloride CAS No.51012-33-0	Tiapride hydrochloride/CAS No.51012-33-0 is a selective and orally active D2 and D3 dopamine receptors antagonist with IC50 values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent.	price>
R-C-2623	Y-27632 CAS:146986-50-7	Y-27632 is an orally active,ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300nM,respectively.Y-27632 attenuates Doxorubicin-induced apoptosis of human cardiac stem cells.Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells.	price>
R-R-4323	MLS1547 CAS No.315698-36-3	MLS1547/CAS No.315698-36-3 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 μM). MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 μM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated β-arrestin recruitment to the D2R (IC50=9.9 μM).	price>
R-C-2624	Adaphostin CAS:241127-58-2	Adaphostin is a novel activator of Fas-mediated death pathway in Bcr/Abl-positive leukaemia.	price>
R-R-4324	Halopemide CAS No.59831-65-1	Halopemide/CAS No.59831-65-1 is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.	price>

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