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Catalog	name	Description	price
R-C-2714	BMS-911543 CAS:1271022-90-2	BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase(JAK)with potential antineoplastic activity.JAK2 inhibitor BMS-911543 selectively inhibits JAK2,thereby preventing the JAK/STAT(signal transducer and activator of transcription)signaling cascade,including activation of STAT3.This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation.	price>
R-R-4414	Haloperidol-d4-1 CAS No.136765-35-0	Haloperidol-d4-1/CAS No.136765-35-0 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist.	price>
R-C-2715	AZD-9291 (Osimertinib) CAS:1271022-90-2	AZD-9291 is a third-generation EGFR inhibitor,showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.	price>
R-R-4415	Dexpramipexole-d3 dihydrochloride CAS No.1432230-09-5	Dexpramipexole-d3 (dihydrochloride)/CAS No.1432230-09-5 is the deuterium labeled Dexpramipexole. Dexpramipexole((R)-Pramipexole), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist.	price>
R-C-2716	FASN-IN-1 CAS:1808260-84-5	FASN-IN-1 is a fatty acid synthase(FASN)inhibitor extracted from patent WO2015134790A1,compound 56.	price>
R-R-4416	Molindone-d8 CAS No.1189805-13-7	Molindone-d8/CAS No.1189805-13-7 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses.	price>
R-C-2717	OSI-420 CAS:183320-51-6	OSI-420(Desmethyl Erlotinib,CP-473420)is an orally active EGFR tyrosin kinase inhibitor,which inhibits receptor tyrosine kinases(TKs)by inhibition of the intercellular domain .	price>
R-R-4417	Raclopride-d5 hydrochloride CAS No.1217623-85-2	Raclopride-d5 (hydrochloride)/CAS No.1217623-85-2 is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively.	price>
R-C-2718	Butein CAS:487-52-5	Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells.Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a.Butein is a SIRT1 activator(STAC).	price>
R-R-4418	Quetiapine-d8 fumarate CAS No.1185247-12-4	Quetiapine-d8 (fumarate)/CAS No.1185247-12-4 is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.	price>
R-C-2719	AEE788 (NVP-AEE788)	AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor(EGFR),human epidermal growth factor receptor 2(HER2),and vascular endothelial growth factor receptor 2(VEGF2),resulting in receptor inhibition, the inhibition of cellular proliferation,and induction of tumor cell and tumor-associated endothelial cell apoptosis.	price>
R-R-4419	A-437203 CAS No.220519-06-2	A-437203/CAS No.220519-06-2 is a selective D3 receptor antagonist with Ki of 71, 1.6, and 6220 nM for D2, D3, and D4 receptors, respectively.	price>
R-C-2720	Niclosamide CAS:50-65-7	Inhibitor of the STAT3 signaling pathway;inhibits the activation,nuclear translocation and transactivation of STAT3.Displays selectivity for STAT3 over STAT1,STAT5,JAK1,JAK2 and Src kinases.Inhibits the transcription of STAT3 target genes and induces cell growth inhibition,apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3.Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro;displays antineoplastic effects in acute myelogenous leukemia(AML)stem cells.	price>
R-R-4420	7a,25-Dihydroxycholesterol CAS No.64907-22-8	7α, 25-dihydroxycholesterol (7α,25-OHC)/CAS No.64907-22-8 is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells.	price>
R-C-2721	NSC 74859 CAS:501919-59-1	S3I-201(NSC 74859)is a novel inhibitor of Stat3 that inhibits Stat3,Stat3 complex formation and Stat3-DNA binding activity in vitro(IC50=86±33µM)and Stat3-dependent transcriptional activities.	price>
R-R-4421	GSK682753A CAS No.1334294-76-6	GSK682753A/CAS No.1334294-76-6 is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.	price>
R-C-2722	CP-724714 CAS:537705-08-1	CP-724714 is a potent,selective and orally active ErbB2(HER2)tyrosine kinase inhibitor,with an IC50 of 10nM.CP-724714 displays a marked selectivity against EGFR kinase(IC50=6400nM).CP-724714 potently inhibits ErbB2 receptor autophosphorylation in intact cells.Antitumor activities.	price>
R-R-4422	ML401 CAS No.1597489-14-9	ML401/CAS No.1597489-14-9, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity.	price>
R-C-2723	AC480 (BMS-599626) CAS:714971-09-2	BMS-599626(AC480)is a selective and orally bioavailable HER1 and HER2 inhibitor,with IC50s of 20 and 30nM,respectively.BMS-599626 displays~8-fold less potent to HER4(IC50=190nM),>100-fold to VEGFR2,c-Kit,Lck,MEK. BMS-599626 inhibits tumor cell proliferation,and has potential to increase tumor response to radiotherapy.	price>
R-R-4423	SAE-14 CAS No.1241280-25-0	SAE-14 (compound SAE-14)/CAS No.1241280-25-0 is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.	price>

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