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Catalog	name	Description	price
R-R-4434	NU6027 CAS No.220036-08-8	NU6027/CAS No.220036-08-8 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.	price>
R-C-2735	Telotristat CAS：1033805-28-5	Telotristat(LP-778902)is the acid form of Telotristat ethyl,and the active metabolite of LX1606(Telotristat etiprate),which is an orally bioavailable, small-molecule,tryptophan hydroxylase(TPH)inhibitor and serotonin synthesis inhibitor with potential antiserotonergic activity.	price>
R-R-4435	Elimusertib-d3	Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity.	price>
R-C-2736	Dafadine-A CAS:1065506-69-5	Dafadine-A,an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).	price>
R-R-4436	KU 59403 CAS No.845932-30-1	KU 59403/CAS No.845932-30-1 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively.	price>
R-C-2737	Indoximod (NLG-8189) CAS:110117-83-4	Indoximod(1-Methyl-D-tryptophan;NLG-8189)is an indoleamine 2,3-dioxygenase(IDO)pathway inhibitor with a Ki of 19μM.	price>
R-R-4437	SKLB-197 CAS No.2713577-16-1	SKLB-197/CAS No.2713577-16-1 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.	price>
R-C-2738	Tunicamycin CAS:11089-65-9	Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase(GPT).Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum(ER)and induces ER stress,and causes blocking of DNA synthesis and cell cycle arrest in G1 phase.	price>
R-R-4438	ATR-IN-4 CAS No.2574545-45-0	ATR-IN-4/CAS No.2574545-45-0 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13).	price>
R-C-2739	PF-04620110 CAS:1109276-89-2	PF-04620110 is a potent,selective and orally bioavailable diglyceride acyltransferase-1(DGAT-1)inhibitor with an IC50 of 19nM.	price>
R-R-4439	Tozasertib CAS No.639089-54-6	Tozasertib (VX 680; MK-0457)/CAS No.639089-54-6 is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.	price>
R-C-2740	VER 155008 CAS:1134156-31-2	VER-155008 is an inhibitor of Hsp70,with IC50s of 0.5μM,2.6μM,and 2.6μM for Hsp70,Hsc70 and Grp7,respectively,and with a Kd of 0.3μM for Hsp70.	price>
R-R-4440	JAB-2485 CAS No.2899209-55-1	JAB-2485/CAS No.2899209-55-1 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer.	price>
R-C-2741	TAK 21d CAS:1143578-94-2	TAK-21d is a potent FAAH Inhibitor.	price>
R-R-4441	Hesperadin CAS No.422513-13-1	Hesperadin/CAS No.422513-13-1 is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral.	price>
R-C-2742	XL-888 CAS:1149705-71-4	XL888 is an orally bioavailable,ATP-competitive,small-molecule inhibitor of heat shock protein 90(Hsp90)with potential antineoplastic activity.	price>
R-R-4442	AMG 900 CAS No.945595-80-2	AMG 900/CAS No.945595-80-2 is a potent and highly selective pan-Aurora kinases inhibitor with IC50 of 5 nM, 4 nM and 1 nM for Aurora A, B and C, respectively.	price>
R-C-2743	AZD7687 CAS:1166827-44-6	AZD7687 is a potent,selective,reversible and orally active diacylglycerol acyltransferase 1(DGAT1)inhibitor with an IC50 of 80nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research.	price>
R-R-4443	ZM-447439 CAS No.331771-20-1	ZM-447439/CAS No.331771-20-1 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively.	price>
R-C-2744	AP-III-a4 CAS:2070014-95-6	ENOblock(AP-III-a4)is a novel small molecule which is the first,nonsubstrate analogue that directly binds to enolase and inhibits its activity(IC50=0.576uM);inhibit cancer cell metastasis in vivo.	price>

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