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Catalog	name	Description	price
R-R-4444	LY3295668 CAS No.1919888-06-4	LY3295668 (AK-01)/CAS No.1919888-06-4 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.	price>
R-C-2745	nTZDpa CAS:118414-59-8	Potent,selective non-thiazolidinedione PPARγ partial agonist (EC50=57nM);produces~25% maximum efficacy.Antagonizes full agonist activity by ~60%(IC50~285nM).Displays no activity at PPARα or PPARδ receptors.	price>
R-R-4445	PF-03814735 CAS No.942487-16-3	PF-03814735/CAS No.942487-16-3 is a potent, orally available, ATP-competitive and reversible aurora A and aurora B inhibitor with IC50s of 0.8 and 0.5 nM, respectively.	price>
R-C-2746	Isosafrole CAS:120-58-1	Isosafrole,a stiripentol analog,is a potent LDH inhibitor.Stiripentol is a new-generation antiepileptic drug,and its chemical structure is unrelated to other antiepileptic drugs.Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase(LDH),which is a component of the astrocyte-neuron lactate shuttle.	price>
R-R-4446	MLN8054 CAS No.869363-13-3	MLN8054/CAS No.869363-13-3 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.	price>
R-C-2747	DASA-58 CAS:1203494-49-8	DASA-58 is a potent activator of pyruvate kinase M2(PKM2)with an AC90 of 680 nM, and an AC50 of 38nM.	price>
R-R-4447	JB170 CAS No.2705844-82-0	JB170/CAS No.2705844-82-0 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase.	price>
R-C-2748	PF-04971729(Ertugliflozin) CAS:1210344-57-2	Ertugliflozin(PF-04971729)is a potent,selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2),with an IC50 of 0.877nM for h-SGLT2.Has the potential for the treatment of type 2 diabetes mellitus.	price>
R-R-4448	BI-847325 CAS No.1207293-36-4	BI-847325/CAS No.1207293-36-4 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. BI-847325 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-2749	PLP (139-151) CAS:122018-58-0	Synthetic myelin proteolipid protein(PLP)fragment.Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE),an animal model of multiple sclerosis.	price>
R-R-4449	SP-96 CAS No.2682114-54-9	SP-96/CAS No.2682114-54-9 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC).	price>
R-C-2750	Etomoxir CAS:124083-20-1	Etomoxir((R)-(+)-Etomoxir)is an irreversible inhibitor of carnitine palmitoyltransferase 1a(CPT-1a),inhibits fatty acid oxidation(FAO)through CPT-1a and inhibits palmitate β-oxidation in human,rat and guinea pig.	price>
R-R-4450	TCS7010 CAS No.1158838-45-9	TCS7010/CAS No.1158838-45-9 is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.	price>
R-C-2751	NMS-E973 CAS:1253584-84-7	NMS-E973 is a potent and selective inhibitor of HSP90.NMS-E973 binds to the ATP binding site of Hsp90α with a DC50 of <10nM.NMS-E973 is able to cross the blood-brain barrier(BBB).Antitumor efficacy.	price>
R-R-4451	PF 477736 CAS No.952021-60-2	PF 477736 (PF 00477736)/CAS No.952021-60-2 is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.	price>
R-C-2752	Radicicol CAS:496054-87-6	Radicicol is an inhibitor of Hsp90 with an IC50 value of 1μM.Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation.Radicicol is an antifungal antibiotic with antimalarial activity,impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB.	price>
R-R-4452	Ilorasertib hydrochloride CAS No.1847485-91-9	Ilorasertib (ABT-348) hydrochloride/CAS No.1847485-91-9 is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF, PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).	price>
R-C-2753	SR 1664 CAS:1338259-05-4	SR1664 is a PPARγ antagonist.SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation(IC50=80nM;Ki=28.67nM).	price>
R-R-4453	SCH-1473759 hydrochloride CAS No.1094067-13-6	SCH-1473759 hydrochloride/CAS No.1094067-13-6 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.	price>
R-C-2754	Tolcapone CAS:134308-13-7	Tolcapone(Ro 40-7592)is a selective,orally active and powerful mixed(peripheral and central)COMT inhibitor with an IC50 of 773 nM in the liver.Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis.Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.	price>

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