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Catalog	name	Description	price
R-R-4454	CCT129202 CAS No.942947-93-5	CCT129202/CAS No.942947-93-5 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.	price>
R-C-2755	Atorvastatin Calcium CAS:134523-03-8	Potent HMG-CoA reductase inhibitor(IC50=8 nM).Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.	price>
R-R-4455	Chiauranib CAS No.1256349-48-0	Chiauranib (CS2164)/CAS No.1256349-48-0 is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects.	price>
R-C-2756	VT-464 racemate CAS:1375603-36-3	Seviteronel racemate(VT-464 racemate)is the racemate form of Seviteronel(VT-464),which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition.	price>
R-R-4456	TAS-119 CAS No.1453099-83-6	TAS-119/CAS No.1453099-83-6 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.	price>
R-C-2757	Brinzolamide CAS:138890-62-7	Brinzolamide(AL 4862)is a potent carbonic anhydrase II inhibitor with IC50 of 3.19nM.	price>
R-R-4457	PHA-680632 CAS No.398493-79-3	PHA-680632/CAS No.398493-79-3 is an aurora kinase inhibitor with IC50s of 27, 135 and 120 nM for aurora A, B and C, respectively.	price>
R-C-2758	PF-4981517 CAS:1390637-82-7	CYP3cide(PF-4981517)is a potent,selective and time-dependent inhibitor of cytochrome P4503A4(CYP3A4).The IC50 values for Midazolam 1-hydroxylase activity are 0.03μM,17μM,and 71μM for CYP3A4,CYP3A5, and CYP3A7,respectively.CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism.	price>
R-R-4458	NU6140 CAS No.444723-13-1	NU6140/CAS No.444723-13-1 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively. Enhances the apoptotic effect, with anti-cancer activity.	price>
R-C-2759	GSK 2830371 CAS:1404456-53-6	GSK 2830371 is a WiP1 inhibitor.It inhibits cell growth and tumor growth in lymphoma and neuroblastoma models.	price>
R-R-4459	CD532 hydrochloride CAS No.2926498-81-7	CD532 hydrochloride/CAS No.2926498-81-7 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.	price>
R-C-2760	PACOCF3 CAS：141022-99-3	Phospholipase A2 inhibitor.	price>
R-R-4460	DB0614 CAS No.2769753-47-9	DB0614 (Example 21)/CAS No.2769753-47-9 is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity.	price>
R-C-2761	YM 26734 CAS：144337-18-8	YM-26734 is an inhibitor of rabbit platelet sPLA2.YM-26734 has been used to ameliorate local inflammatory responses in TPA-induced mouse ear edema.	price>
R-R-4461	ENMD-2076 Tartrate CAS No.1453868-32-0	ENMD-2076 Tartrate/CAS No.1453868-32-0 is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.	price>
R-C-2762	GSK 2837808A CAS：1445879-21-9	GSK2837808A is a potent,selective lactate dehydrogenase A(LDHA)inhibitor(IC50 values are 1.9 and 14nM for LDHA and LDHB respectively).	price>
R-R-4462	CCT241736 CAS No.1402709-93-6	CCT241736/CAS No.1402709-93-6 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM).	price>
R-C-2763	DGAT1-IN-1 CAS：1449779-49-0	DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of<10nM(cell lysate from Hep3B cells overexpressing human DGAT1).	price>
R-R-4463	Aurora kinase inhibitor-3 CAS No.879127-16-9	Aurora kinase inhibitor-3/CAS No.879127-16-9 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket.	price>
R-C-2764	Pralatrexate (NSC 754230) CAS：146464-95-1	Pralatrexate(NSC 754230)is an antifolate, and structurally a folate analog.Its IC50 is<300nM in some cell lines.Pralatrexate induces tumor cell apoptosis.	price>

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