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Catalog	name	Description	price
R-R-4585	GS-441524 CAS No.1191237-69-0	GS-441524/CAS No.1191237-69-0, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM.	price>
R-R-4586	Novobiocin sodium CAS No.1476-53-5	Novobiocin (Albamycin) sodium/CAS No.1476-53-5 is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity.	price>
R-C-2917	PAMAM-PEG-EPOX	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. As an excellent nano single molecule surfactant, it has good solubilization, demulsification and stability. It has very good practical value in emulsion explosive, oil exploitation, sewage treatment and drug solubilization.	price>
R-R-4587	IMT1 CAS No.2304621-31-4	IMT1/CAS No.2304621-31-4 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.	price>
R-C-2918	PAMAM-PEG-HZ	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. As an excellent nano single molecule surfactant, it has good solubilization, demulsification and stability. It has very good practical value in emulsion explosive, oil exploitation, sewage treatment and drug solubilization.	price>
R-R-4588	Idarubicin hydrochloride CAS No.57852-57-0	Idarubicin hydrochloride/CAS No.57852-57-0 is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.	price>
R-C-2919	PAMAM-PEG-NPC	Nitrophenyl carbonate PEG derivatives can be used to modify proteins, peptides and other materials through amino acids or other acid active chemical groups. PEG derivatives can increase solubility and stability and reduce immunogenicity of peptides and proteins.Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. As an excellent nano single molecule surfactant, it has good solubilization, demulsification and stability. It has very good practical value in emulsion explosive, oil exploitation, sewage treatment and drug solubilization.	price>
R-R-4589	Risdiplam CAS No.1825352-65-5	Risdiplam (RG7916)/CAS No.1825352-65-5 is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.	price>
R-C-2920	PAMAM-PEG-OPSS	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. As an excellent nano single molecule surfactant, it has good solubilization, demulsification and stability. It has very good practical value in emulsion explosive, oil exploitation, sewage treatment and drug solubilization.Ortho-pyridyl disulfide reacts with thiol group to form a stable disulfide bond while a thiol pyridyl group is released.	price>
R-R-4590	ML216 CAS No.1430213-30-1	ML216 (CID-49852229)/CAS No.1430213-30-1 is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 µM. Antitumor avtivity.	price>
R-C-2921	PAMAM-PLA-EPOX	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. As an excellent nano single molecule surfactant, it has good solubilization, demulsification and stability. It has very good practical value in emulsion explosive, oil exploitation, sewage treatment and drug solubilization Ethylene oxide is an important intermediate in organic synthesis, which is used to prepare ethylene glycol, antifreeze, synthetic detergent, emulsifier and plastics.	price>
R-R-4591	ML-60218 CAS No.577784-91-9	ML-60218/CAS No.577784-91-9 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs.	price>
R-C-2922	PAMAM-PLA-Protected amines(Fmoc, tBOC)	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. Dendrimers link PLA and PLA links ammonia.	price>
R-R-4592	Simeprevir CAS No.923604-59-5	Simeprevir (TMC435; TMC435350)/CAS No.923604-59-5 is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.	price>
R-C-2923	PAMAM-PCL-ACRL	Polyamide amine dendrimer (PAMAM) is one of the earliest synthesized dendrimers. It is monodisperse, with a cavity inside and a high-density amine group on the surface. PCL has good biocompatibility, good organic polymer compatibility and good biodegradability. It can be used as cell growth support material and compatible with a variety of conventional plastics.	price>
R-R-4593	BAY-2402234 CAS No.2225819-06-5	BAY-2402234/CAS No.2225819-06-5 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies.	price>
R-C-2924	PS-b-PBd	Polybutadiene is mainly used as synthetic rubber. Solution polymerized polybutadiene is often used together with styrene butadiene rubber or natural rubber as tread and carcass of tires. Polystyrene resin, English name is poly (styrene), molecular formula is C8H8, general type (R) is suitable for packaging materials; Flame retardant (f) is suitable for building and thermal insulation materials.	price>
R-R-4594	5-Fluorouridine CAS No.316-46-1	5-Fluorouridine/CAS No.316-46-1, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis.	price>
R-C-2925	PDPA5K	Block copolymer micelles are usually formed by self-assembly of amphiphilic block copolymers in aqueous media.Hydrophilic and hydrophobic blocks form shell and core micelles,respectively.Methoxypolyethylene glycol(MPEG)-b-Poly(2-diisopropylamino)ethyl methacrylate(PDPA)block copolymer was synthesized by atom transfer radical polymerization of 2-bromoisobutyl bromide and MPEG in the presence of triethylamine catalyst.	price>
R-R-4595	NSC 617145 CAS No.203115-63-3	NSC 617145/CAS No.203115-63-3 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases.	price>

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