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R-C-3032 AS-604850 CAS:648449-76-7 AS-604850 is a selective,ATP-competitive PI3Kγ inhibitor with IC50 of 250nM,over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.Only for scientific research, not for human body. price>
R-R-4702 4-Trifluoromethylumbelliferyl-b-D-galactopyranoside CAS No:117153-55-6 4-Trifluoromethylumbelliferyl β-D-galactopyranoside/4-Trifluoromethylumbelliferyl-beta-D-galactopyranoside/CAS No:117153-55-6 is a chromogenic substrate that can be used to detect the presence of β-glucuronidase and β-galactosidase in a variety of organisms. This compound has been shown to be useful for the detection of bacteria such as E. coli, Salmonella, and Listeria monocytogenes. 4TFU has been shown to hydrolyze at pH values between 5 and 8. The reaction starts with a color change from yellow to blue at pH 5, which changes again to green at pH 8. The equivalence point for this substrate is at pH 6.4, where it produces an orange color. price>
R-R-4703 Trifluoroacetamidoethyl-SS-propionic NHS ester CAS: 2380318-60-3 Trifluoroacetamidoethyl-SS-propionic NHS ester/CAS: 2380318-60-3 is a cleavable linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The disulfide bond can be cleaved under reduction conditions. Reagent grade, for research purpose. price>
R-R-4704 1,1,1-Trifluoroethyl-PEG5-alcohol CAS: 1807512-41-9 1,1,1-Trifluoroethyl-PEG5-alcohol/CAS: 1807512-41-9 is a PEG linker containing a trifluoroethyl and alcohol group. The trifluoroethyl group is used to react with lysine and other primary amine groups in proteins, antibody and other molecules and surfaces. The alcohol group can react to further derivatize the compound. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media. price>
R-R-4705 Tris(2-(4,6-difuorophenyl)pyridine)iridium(III) CAS .387859-70-3 Tris(2-(4,6-difluorophenyl)pyridine)iridium(III)/Tris[2-(4,6-difluorophenyl)pyridinato-C2,N]iridium(III)/CAS .387859-70-3 is a coordination compound containing an iridium(III) ion coordinated with three ligands, each composed of a 2-(4,6-difluorophenyl)pyridine moiety. This compound is known for its luminescent properties and finds applications in organic light-emitting diodes (OLEDs) and other optoelectronic devices.The complex structure of the compound, with the iridium ion at its center and the three difluorophenylpyridine ligands surrounding it, contributes to its unique optical properties. The presence of the difluorophenyl groups on the ligands can influence the emission characteristics and efficiency of the compound, making it useful in the development of efficient light-emitting materials. price>
R-R-4706 Brr2-IN-3 CAS No.2104030-82-0 Brr2-IN-3/CAS No.2104030-82-0 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM. price>
R-R-4707 UNC9512 CAS No.3032393-24-8 UNC9512/CAS No.3032393-24-8 is a potent methyl-lysine reader p53 binding protein 1 (53BP1) antagonist. UNC9512 can be used to study the role of 53BP1 in DNA repair, gene editing and tumorigenesis. price>
R-R-4708 CeMMEC13 CAS No.1790895-25-8 CeMMEC13/CAS No.1790895-25-8 is a potent inhibitor of TAF1 (2) bromodomain, with an IC50 of 2.1 μM. price>
R-R-4709 Antipain dihydrochloride CAS No.37682-72-7 Antipain dihydrochloride/CAS No.37682-72-7 is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice. price>
R-C-3040 Duvelisib (IPI-145) CAS:1201438-56-3 Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. price>
R-R-4710 CM03 CAS No.2101208-44-8 CM03/CAS No.2101208-44-8 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells. price>
R-C-3041 GSK1059615 CAS:958852-01-2 GSK1059615 is a potent, ATP-competitive inhibitor of PI 3-kinase alpha (PI3Kα) with IC50 of 2 nM. GSK1059615 is also a novel inhibitor of PI3Kβ, PI3Kδ, PI3Kγ and mTOR with IC50 of 0.6 nM, 2 nM, 5 nM and 12 nM, respectively. price>
R-R-4711 NSAH CAS No.1099592-35-4 NSAH/CAS No.1099592-35-4 is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively. price>
R-C-3042 PIK-90 CAS:677338-12-4 PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ. price>
R-R-4712 Sorivudine CAS No.77181-69-2 Sorivudine (BV-araU)/CAS No.77181-69-2 is an orally active synthetic pyrimidine nucleoside antimetabolite agent. Sorivudine derives its antiviral activity from selective conversion by a specific thymidine kinase present in certain DNA viruses to nucleotides, which can in turn interfere with viral DNA synthesis. price>
R-C-3043 TG100-115 CAS:677297-51-7 TG100-115, inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively), whereas both PI3Kα and -β were relatively unaffected (IC50 values>1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values <1 μM. price>
R-R-4713 N-Nitrosodiethylamine-d10 CAS No.1219794-54-3 N-Nitrosodiethylamine-d10/CAS No.1219794-54-3 is the deuterium labeled N-Nitrosodiethylamine[1]. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. price>
R-C-3044 ZSTK474 CAS:475110-96-4 ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. price>
R-C-5834 DSPE-polyethylene glycol550-GGGGK(TAMRA)TILVSRSTQTGRRRRRRRR DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is a lipid molecule that can be incorporated into lipid bilayers, such as liposomes.It provides stability and structure to lipid-based nanostructures.PEG (polyethylene glycol) is a biocompatible and hydrophilic polymer that is often attached to lipids to improve the stability, circulation time, and biocompatibility of liposomes.TAMRA is a commonly used fluorescent dye that can be conjugated to peptides(TILVSRSTQTGRRRRRRRR)or other biomolecules for visualization purposes.The molecular weight of PEGs varies. price>
R-R-4714 Nogalamycin CAS No.1404-15-5 Nogalamycin/CAS No.1404-15-5 is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer. price>