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R-M1-8895 Hyaluronic acid-ZIF-8 drug loading(Chloroquine and 2-Deoxy-D-glucose) 100-200nm Hyaluronic acid-ZIF-8 drug loading refers to a process in which the drug delivery system composed of hyaluronic acid and zeolitic imidazolate framework-8 (ZIF-8) is utilized to load specific drugs.The process of hyaluronic acid-ZIF-8 drug loading with Chloroquine and 2-Deoxy-D-glucose likely involves encapsulating these drugs within the pores of the ZIF-8 framework in combination with hyaluronic acid. The resulting drug delivery system can potentially target cancer cells through the CD44-HA interactions while delivering the loaded drugs to specific cellular targets, taking advantage of the specific properties of both the drugs and the carrier system. price>
R-M-5443 Difluorocarboxyfluorescein NHS Ester, 6-isomer Difluorocarboxyfluorescein NHS Ester, 6-isomer (also known as Oregon Green™ 488 Carboxylic Acid, Succinimidyl Ester, 6-isomer) is an amine-reactive fluorinated analog of fluorescein that overcomes some of the key limitations of fluorescein, including greater photostability and a lower pKa (pKa ~ 4.7 versus 6.4 for fluorescein), making its fluorescence essentially pH insensitive in the physiological pH range.Difluorocarboxyfluorescein NHS Ester, is a preferred, routinely used fluorescent dye for labeling proteins, peptides and nucleotides. price>
R-C-4778 DSPE-PEG350-GNYTCEVTELTREGETIIELK 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol is a PEG-modified lipids.Suitable for the development of long circulating liposomes.GNYTCEVTELTREGETIIELK can interact with signal regulatory protein-α (SIRPα) on macrophages to inhibit phagocytic uptake and in vivo clearance .CD47 has the sequence GNYTCEVTELTREGETIIELK (SEQ ID NO:9). price>
R-M1-8896 BSA Modified (NH2-PEG-gold nanoparticles) Combining BSA and NH2-PEG modifications on gold nanoparticles offers various advantages. The BSA layer provides stability to the nanoparticles and helps prevent non-specific adsorption and interactions with biomolecules, making them more suitable for biological applications. The NH2-PEG coating can further enhance the biocompatibility of the nanoparticles and provide sites for additional functionalization or conjugation with targeting molecules, drugs, or imaging agents. This allows for the customization of the nanoparticles for specific purposes, such as targeted drug delivery or imaging.These modified gold nanoparticles have potential applications in drug delivery, biomedical imaging, and diagnostic tools, taking advantage of their stability, biocompatibility and the ability to be tailored to different functions. price>
R-M-5444 Difluorocarboxyfluorescein NHS Ester, 5-isomer Difluorocarboxyfluorescein NHS Ester, 5-isomer (Oregon Green™ 488 Carboxylic Acid, Succinimidyl Ester, 5-isomer equivalent) is an amine-reactive fluorinated analog of fluorescein that overcomes some of the key limitations of fluorescein, including greater photostability and a lower pKa (pKa ~ 4.7 versus 6.4 for fluorescein), making its fluorescence essentially pH insensitive in the physiological pH range. Difluorocarboxyfluorescein NHS Ester, is a preferred, routinely used fluorescent dye for labeling proteins, peptides and nucleotides. price>
R-C-4779 DSPE-polyethylene glycol550-GNYTCEVTELTREGETIIELK 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol is a PEG-modified lipids.Suitable for the development of long circulating liposomes.GNYTCEVTELTREGETIIELK can interact with signal regulatory protein-α (SIRPα) on macrophages to inhibit phagocytic uptake and in vivo clearance . CD47 has the sequence GNYTCEVTELTREGETIIELK (SEQ ID NO:9). price>
R-M1-8897 Me-Tet-peg9-NHS,cas2143955-78-4 Me-Tet-peg9-NHS/Methyl-tetrazine-peg9-NHS/Me-Tetrazine-peg9-NHS(CAS:2143955-78-4) compound could potentially be used for selective and controlled bioconjugation of molecules, such as proteins or peptides, enabling the attachment of the tetrazine functionality to specific sites on biomolecules for various applications, including imaging, targeted drug delivery, or diagnostics. Additionally, the PEG spacer may provide increased water solubility and biocompatibility to the resulting conjugates. price>
R-M-5445 Difluorocarboxyfluorescein Azide, 6-isomer 2’,7’-Difluorocarboxyfluorescein Azide,6-isomer (also under Oregon Green 488 Azide (Oregon Green™ 6-Carboxamido-(6-Azidohexanyl), Triethylammonium Salt), 6-isomer name) is a bright, green-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. 2’,7’-Difluorocarboxyfluorescein fluorinated analog of fluorescein that overcomes some of the key limitations of fluorescein, including greater photostability and a lower pKa (pKa ~ 4.7 versus 6.4 for fluorescein), making its fluorescence essentially pH insensitive in the physiological pH range. price>
R-C-4780 GNYTCEVTELTREGETIIELK-PEG750-DSPE 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol is a PEG-modified lipids.Suitable for the development of long circulating liposomes.GNYTCEVTELTREGETIIELK can interact with signal regulatory protein-α (SIRPα) on macrophages to inhibit phagocytic uptake and in vivo clearance . CD47 has the sequence GNYTCEVTELTREGETIIELK (SEQ ID NO:9). price>
R-M1-8898 Mal-PEG3-amine Mal-PEG3-amine/Maleimide-PEG3-amine/Maleimide-PEG3-NH2/amine-PEG3-Mal/amine-PEG3-Maleimide is a versatile compound that can be employed in bioconjugation and biochemistry to modify and functionalize various biomaterials, surfaces, or nanoparticles. It provides a flexible platform for the selective and controlled conjugation of molecules, contributing to the development of tailored bioconjugates with specific properties and functionalities. price>
R-M-5446 5(6)-Carboxyrhodamine 110 NHS Ester 5(6)-Carboxyrhodamine 110 NHS Ester also known as Rhodamine Green™ Carboxylic Acid. The amine-reactive 5(6)-Carboxyrhodamine 110 NHS Ester can be used to create bright and photostable green-fluorescent bioconjugates with excitation/emission maxima ~502/527 nm.(5(6)-Carboxyrhodamine 110 NHS Ester)The conjugates of this dye often used for Fluorescence Correlation Spectroscopy (FCS). For many applications, 5(6)-Carboxyrhodamine 110 NHS Ester is preferred over 5-(6)-carboxyfluorescein NHS ester or FITC because of its exceptional photostability and fluorescence insensitivity to pH (4-9). price>
R-C-4781 DSPE-PEG-PVGLIG-PEG 2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated polyethylene glycol (CPG) is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. It is a functional polyethylene glycol preparation. The polyethylene glycol phospholipid liposome forms high-quality materials, which can be used for drug delivery, gene transfection and vaccine delivery. Peptides and other groups can be coupled. price>
R-M1-8899 DBCO-NH-PEG1-CH2CH2COONHS ester DBCO-NH-PEG1-CH2CH2COONHS ester represents a versatile compound for bioconjugation and biochemistry, offering a platform for the functionalization and modification of various biomaterials, surfaces, or nanoparticles. It allows for the selective and controlled conjugation of molecules, contributing to the development of tailored bioconjugates with specific properties and functionalities for various biomedical and biotechnological applications. price>
R-M-5447 5-TAMRA Cadaverine 5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3). 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. price>
R-M1-8900 DBCO-PEG3-Concanavalin A DBCO-PEG3-Concanavalin A bioconjugate could be used in a variety of biological and biomedical studies, including in glycoprotein and glycan research, affinity chromatography, and targeted drug delivery systems. price>
R-M-5448 TAMRA DBCO TAMRA DBCO reacts with azides via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. This copper-free variation of click reaction overcomes a major shortcoming of copper-catalyzed click reaction – the need for copper catalyst. Copper can damage fluorescent proteins, Quantum Dot nanocyrstals, certain enzymes, and photoproteins like RPE. The presence of copper is also problematic in staining the surface of live cells.In application where the presence of copper is a concern TAMRA DBCO is an ideal alternative to copper requiring fluorescent alkynes. price>
R-C-4783 DSPE-PEG-Citraconic Anhydride 1.2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated polyethylene glycol (CPG) is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. It is a functional polyethylene glycol preparation. The polyethylene glycol phospholipid liposome forms high-quality materials, which can be used for drug delivery, gene transfection and vaccine delivery. price>
R-M1-8901 Rhodamine-HSA Rhodamine-HSA is a fluorophore-labeled albumin protein used in biological research and imaging applications. The rhodamine label allows for visualization and tracking of the protein in cellular and molecular studies. This conjugate is commonly used as a fluorescent tracer in studies related to drug delivery, tissue distribution, and protein binding. price>
R-M-5449 TAMRA Picolyl Azide TAMRA Picolyl Azide is an advanced fluorescent probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The rate of CuAAC reaction depends on concentrations of all reagents, including copper, thus the raise of the effective copper concentration at the reaction site dramatically increase the rate of CuAAC reaction without the need to increase concentration of azide reagent and copper. This probe is compatible with various excitation sources including mercury arc, tungsten and xenon arc lamps, the 544 nm line of the Helium-Neon laser and the 532 nm green laser line.In addition, the use of TAMRA Picolyl Azide instead of conventional TAMRA Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling.In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This will be of special value for the detection of low abundance targets or where significant increase in signal intensity is desired. price>
R-C-4784 DSPE-PEG350-Citraconic Anhydride 1.2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated polyethylene glycol (CPG) is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. It is a functional polyethylene glycol preparation. The polyethylene glycol phospholipid liposome forms high-quality materials, which can be used for drug delivery, gene transfection and vaccine delivery. price>