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R-Mcs-236 DOPS:DOPC:Chol:DOPE-N-DBCO-based Fluoroliposome Rhodamine lipid (headgroup)-DBCO The formulation of DOPS:DOPC:Chol:DOPE-N-DBCO (20:49:30:1) fluoroliposomes that incorporate a Rhodamine lipid headgroup offers a versatile platform for advanced drug delivery and bioimaging. The click chemistry functionality provided by the DBCO group enhances the conjugation capabilities with targeted therapeutics, while the rhodamine fluorescence facilitates tracking and visualization in cellular studies. These properties position this formulation as a powerful tool in both research and clinical settings, particularly in targeted therapy and molecular imaging applications. price>
R-XASYS-00237 Pennogenin,cas:507-89-1 Pennogenin is a bioactive component which can be isolated from T. govanianum rhizomes. Pennogenin exhibits significant in vitro inhibitory effect on release of ROS. price>
R-R-0237 L-Erythrulose CAS 533-50-6 L-Erythrulose/L-(+)-Erythrulose is an organic compound that is a sugar alcohol. It can be synthesized from the aldol reaction of glycolaldehyde and dehydroascorbic acid, which are both found in natural sources. L-Erythrulose has shown to have intramolecular hydrogen transfer (H-transfer) reactions, where the hydroxyl group migrates from one C atom to another. This kinetic data was obtained using surface methodology on model systems containing l-erythrulose and bacteria with wild-type or mutant strains. The conformational properties of L-erythrulose were also investigated by comparing its chemical structures with those of other sugars. price>
R-Mcs-237 DOPS:DOPC:Chol:DOPE-N-DBCO(20:49:30:1molar ratio)-based Fluoroliposome Cyanine 5 lipid-DBCO DOPS:DOPC:Chol:DOPE-N-DBCO(20:49:30:1molar ratio)-based Fluoroliposome Cyanine 5 lipid-DBCO can potentially be used in the field of theranostics, which combines therapy and diagnostics. By attaching therapeutic agents for treatment and fluorescent tags for imaging, one could monitor therapeutic responses in real time.The DBCO group allows for the covalent attachment of azide-functionalized therapeutic agents directly inside or on the surface of the liposome. This enables precise targeting strategies, potentially enhancing efficacy while reducing systemic toxicity. The Cyanine 5 lipid provides a means for non-invasive imaging, enabling visualization of liposome distribution and cellular uptake through fluorescence imaging techniques.This is particularly valuable in applications such as in vivo tumor targeting studies, tracking the biodistribution of therapeutics, or studying cellular dynamics.The strong fluorescence from the Cyanine 5 allows for real-time monitoring of liposome internalization, localization, and migration in live cells using fluorescence microscopy techniques. price>
R-XASYS-00238 4-oxo-2-Nonenal,cas:103560-62-9 4-hydroxy Nonenal(C9H14O2,154.2) is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.It exhibits various biological activities such as cytotoxicity, growth inhibiting activity price>
R-R-0238 Tricin 7-o-glucoside CAS 32769-01-0 Tricine 7-Glucoside/Tricin 7-O-β-D-glucopyranoside/CAS 32769-01-0/Tricin 7-o-glucoside is a natural flavonoid glycoside that has been found in human urine and has been shown to have anti-tumor properties. It inhibits the activity of kinases, which are proteins that play a key role in cell growth and division. Tricin 7-o-glucoside is an analog of tolvaptan, a drug used to treat hyponatremia. This compound has been shown to be a potent inhibitor of several kinases, including those involved in cancer cell growth and survival. It induces apoptosis, or programmed cell death, in cancer cells and has potential as an anticancer agent. Chinese researchers have reported that tricin 7-o-glucoside can inhibit the growth of several types of cancer cells, including breast, colon, and lung cancer cells. This compound could be a promising inhibitor for developing new anticancer drugs. price>
R-Mcs-238 DOPS:DOPC:Chol:DOPE-N-DBCO(20:49:30:1molar ratio)-based Fluoroliposome Cyanine 5.5 lipid-DBCO The DOPS:DOPC:Chol:DOPE-N-DBCO (20:49:30:1 molar ratio) based fluoroliposomes provide a versatile and effective nanoscale platform for drug delivery and bioimaging. The incorporation of Cyanine 5.5 dye allows for fluorescence-based applications, while the specific lipid composition promotes stability and biocompatibility. This formulation offers significant potential for advancements in targeted therapy and diagnostic imaging. Further optimization and exploration of conjugated biomolecules could enhance the specificity and efficacy of these liposomal carriers in clinical applications. price>
R-XASYS-00239 Hexanolamino PAF C-16,cas:137566-83-7 Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16. price>
R-R-0239 L-Serine(2,3,3-d3) CAS 105591-10-4 L-Serine (2,3,3-D3) is an amino acid that has been synthesized and extensively studied in recent years. It is a labeled analog of naturally-occurring serine, where three hydrogen atoms on the methyl group have been replaced by three deuterium atoms. This labeling technique is often used in metabolic studies, where the fate of a compound in the body can be traced by following the isotopically labeled atoms. Serine is important in the biosynthesis of many compounds in the body, such as proteins, nucleotides, and neurotransmitters. It also plays a role in several metabolic pathways, including the one-carbon metabolism pathway and the folate cycle. price>
R-Mcs-239 DOPS:DOPC:Chol:DOPE-N-DBCO(20:49:30:1molar ratio)-based Fluoroliposome Cyanine 7 lipid-DBCO DOPS:DOPC:Chol:DOPE-N-DBCO(20:49:30:1molar ratio)-based Fluoroliposome Cyanine 7 lipid-DBCO provides a highly versatile platform for both drug delivery and bioimaging applications. Utilize near-infrared of Cyanine 7 fluorescent properties for in vivo imaging of cells and tissues, benefiting research in cancer, cardiovascular diseases, and other biomedical fields.Functionalization with DBCO enables conjugation of targeting agents (e.g., antibodies, peptides) for enhanced specificity in drug delivery applications.Combined therapeutic and diagnostic capabilities, enabling simultaneous treatment and imaging to monitor response to therapies. price>
R-XASYS-00240 Pentafluorobenzenesulfonyl fluorescein,cas:728912-45-6 Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for hydrogen peroxide specifically. price>
R-R-0240 Acetynyl modified glucosamine Alkynyl modified glucosamine refers to a modified form of the naturally occurring sugar glucosamine, where an alkynyl group is introduced to the molecule.Alkynyl modified glucosamine derivatives find applications in a range of fields, including bioconjugation, drug delivery systems, chemical biology, and bioorthogonal chemistry. They can be utilized to label or modify biomolecules, such as proteins or carbohydrates, for various purposes like biomaterials synthesis, imaging, and drug discovery. price>
R-Mcs-240 DOPS:DOPC:Chol:DPPE-N-(6-azidohexanoyl) (ammonium salt)-based Fluoroliposome DiA-Azide The DOPS:DOPC:Chol:DPPE-N-(6-azidohexanoyl) (ammonium salt) formulation, especially as a fluoroliposome, is a versatile platform for a range of biological and biomedical applications, particularly in drug delivery and imaging studies. The incorporation of DiA makes these liposomes suitable for in vivo imaging studies, allowing visualization of liposome distribution and dynamics in biological systems. The liposomes could encapsulate therapeutic agents for targeted delivery, aided by the charged interactions and the ability to functionalize with targeting ligands using the azide. Charged liposomes can be employed as adjuvants or carriers for antigens, enhancing immune responses. The azide can be used in various click chemistry applications, enabling the attachment of biomolecules or targeting moieties to the liposomal surface. price>
R-XASYS-00241 EUK 118,cas:186299-34-3 EUK 118(C22H25MnN2O8,500.4) is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 118 exhibits a catalase activity of 35 µM O2 formed/minute from 10 mM hydrogen peroxide. price>
R-R-0241 Methacrylated-collagen Methacrylated collagen is a modified form of collagen, which is a natural protein found in connective tissues. Methacrylated collagen is commonly used in tissue engineering and regenerative medicine applications. The modified collagen can serve as a biocompatible and biodegradable scaffold for cell growth and tissue regeneration. It can be used to create 3D structures, such as hydrogels or films, that mimic the extracellular matrix and support cell attachment, proliferation, and differentiation. price>
R-Mcs-241 DOPS:DOPC:Chol:DPPE-N-(6-azidohexanoyl) (ammonium salt)-based Fluoroliposome DiD-Azide DOPS:DOPC:Chol:DPPE-N-(6-azidohexanoyl) (ammonium salt)(20:49:30:1molar ratio)-based Fluoroliposome DiD-Azide can be used in animal models for tracking and visualizing different organ distributions post-injection, allowing researchers to study pharmacokinetics and biodistribution. Through conjugation of targeting ligands via click chemistry at the azide site, these liposomes can be modified to target specific cells or tissues, enhancing therapeutic efficiency. The presence of the azide group allows for facile coupling with various biomolecules, enabling sophisticated bioconjugation strategies for creating multifunctional delivery systems. price>
R-XASYS-00242 S3QEL-2,cas:890888-12-7 S3QEL-2(C19H25N5,323.4) is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function. price>
R-R-0242 5-ketofructose CAS: 1684-29-3 5-ketofructose, also known as 5-keto-D-fructose or D-fructose 5-ketolactone, is a chemically modified form of the sugar fructose. 5-ketofructose has also been investigated for its potential as a building block in organic synthesis. Its unique structure and reactivity make it a valuable starting material for the synthesis of various compounds, such as pharmaceuticals, in the field of medicinal chemistry. price>
R-Mcs-242 DOPS:DOPC:Chol:DPPE-N-(6-azidohexanoyl)(ammonium salt)-based Fluoroliposome DiI-Azide The fluorescent properties of DiI allow researchers to visualize the biodistribution of these liposomes in live cells or tissues.The azide functionality can be used for click chemistry to attach targeting ligands (e.g., antibodies, peptides) that increase the specificity of liposome uptake by particular cell types.The azide can be functionalized post-fabrication for further modification, allowing extensive customization for specific applications such as biosensing or targeted therapy.These fluorescently labeled liposomes can be used in vivo for tracking, imaging, and evaluating therapeutic strategies in live animal models. price>
R-XASYS-00243 cis-Resveratrol,cas:61434-67-1 Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol(C14H12O3,228.2) is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. price>
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