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Catalog	name	Description	price
R-R-3262	WAY-100135 dihydrochloride CAS No.149055-79-8	WAY-100135 dihydrochloride/CAS No.149055-79-8 is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.	price>
R-C-1563	Apoptozole CAS：1054543-47-3	Apoptozole(Apoptosis Activator VII)is an inhibitor of heat shock protein 70(HSP70)and Hsc70 with dissociation constants Kd of 0.14μM and 0.21μM, respectively.It induces caspase-dependent apoptosis.	price>
R-R-3263	7-Desmethyl-agomelatine CAS No.152302-45-9	7-Desmethyl-agomelatine/CAS No.152302-45-9 is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C.	price>
R-C-1564	go6983 CAS：133053-19-7	Go 6983 is a pan-PKC inhibitor against for PKCα,PKCβ,PKCγ,PKCδand PKCζ with IC50 of 7 nM,7 nM,6nM,10 nM and 60 nM,respectively.	price>
R-R-3264	Donitriptan CAS No.170912-52-4	Donitriptan/CAS No.170912-52-4 is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively.	price>
R-C-1565	Relugolix (TAK-385) CAS：737789-87-6	Relugolix(RVT-601,TAK-385)is a selective antagonist of the gonadotropin-releasing hormone receptor(GnRHR)with IC50 of 0.33 nM and 0.32 nM for human GnRHR and monkey GnRHR,respectively.	price>
R-R-3265	Strictosidinic acid CAS No.150148-81-5	Strictosidinic acid/CAS No.150148-81-5, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice.	price>
R-C-1566	Selonsertib (GS-4997) CAS：1448428-04-3	Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1(ASK1),with potential anti-inflammatory,antineoplastic and anti-fibrotic activities.	price>
R-R-3266	Felcisetrag CAS No.916075-84-8	Felcisetrag (TD-8954)/CAS No.916075-84-8 is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.	price>
R-C-1567	Pamapimod CAS：449811-01-2	Pamapimod(Ro4402257)is a potent,selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β,respectively.Pamapimod has no activity against p38δ or p38γ isoforms.Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.	price>
R-R-3267	Pirenperone CAS No.75444-65-4	Pirenperone (R 47465)/CAS No.75444-65-4 is a 5-HT2 serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity.	price>
R-C-1568	Navitoclax (ABT-263) CAS：923564-51-6	Navitoclax(ABT-263)is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins,such as Bcl-xL,Bcl-2 and Bcl-w,with a Ki of less than 1nM.	price>
R-R-3268	GR 55562 dihydrochloride CAS No.159533-25-2	GR 55562 (dihydrochloride)/CAS No.159533-25-2 is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease.	price>
R-C-1569	Tavaborole (AN-2690) CAS：174671-46-6	AN-2690,an antifungal agent with activity against Trichophyton species,in a topical solution formulation,for the potential treatment of onychomycosis.	price>
R-R-3269	Perospirone hydrochloride CAS No.129273-38-7	Perospirone hydrochloride (SM-9018)/CAS No.129273-38-7 is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.	price>
R-C-1570	ETP46464 CAS：1345675-02-6	ETP46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated(ATM)-and Rad3-related(ATR).	price>
R-R-3270	Urapidil CAS No.34661-75-1	Urapidil/CAS No.34661-75-1 is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.	price>
R-C-1571	Fenebrutinib (GDC-0853) CAS：1434048-34-6	Fenebrutinib(GDC-0853)is a potent,selective, orally available,and noncovalent bruton is tyrosine kinase(Btk)inhibitor with Kis of 0.91 nM,1.6,1.3,12.6,and 3.4 nM for WT Btk,and the C481S,C481R,T474I,T474M mutants.Fenebrutinib has the potential for rheumatoid arthritis and systemic lupus erythematosus research.	price>
R-R-3271	RS 67333 hydrochloride CAS No.168986-60-5	RS 67333 hydrochloride/CAS No.168986-60-5 is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors.	price>
R-C-1572	A66 CAS：1166227-08-2	A66 is a potent and highly selective p110α inhibitor with IC50 of 32 nM in a cell-free assay,>100 fold selectivity for p110α over other class-I PI3K isoforms.A66 blocks phosphoinositide 3-kinase signalling and tumour growth in certain cell types.	price>

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