CW069 CAS No. 1594094-64-0

CW069 is a novel allosteric inhibitor of microtubule kinesin hset.Its IC50 value is 75±20μm,which is significantly selective compared with KSP.IC50 value:75 ± 20μm[1]target:hset-cw069 has obvious selectivity for hset in vitro.The IC50 value of cw069 for hset was 75±20μm,and the selectivity of cw069 for KSP reached the experimental limit.CW069 induced a small but significant increase in the multipolar spindle of MDA-MB-231,which was consistent with the intermediate level of centrosome in untreated cells.After cw069 treatment,the number of multipolar spindles increased in bt549 cells.

msds---CW069