DMG-PEG-CYGRKKRRQRRR

DMG-PEG-CYGRKKRRQRRR/DMG-PEG-TAT(CYGRKKRRQRRR)/CYGRKKRRQRRR-PEG-DMG is a customized membrane penetrating peptide modified functionalized PEG derivative. As a functional modification component added to mRNA/siRNA lipid nanoparticles, the intracellular delivery efficiency of nucleic acid drugs is significantly improved by utilizing TAT transmembrane peptides while retaining the DMG-PEG2000 stealth effect, solving the problem of insufficient transfection efficiency in conventional LNP cells. It can be used to construct nano drug delivery systems that can efficiently penetrate cell membranes, adapt to intracellular delivery research of large molecule drugs such as proteins and peptides, and enhance the intracellular concentration of drugs. Surface functionalization modification of fluorescent and magnetic resonance imaging nanoprobes to facilitate efficient entry of probes into the interior of cells, achieving precise tracking and imaging detection at the cellular level.

msds of DMG-PEG-CYGRKKRRQRRR