DSP-PEG4-TK-COOH

DSP-PEG4-TK-COOH is a ROS-responsive linker molecule designed for:

Anchoring to hydrophobic surfaces (e.g., liposomes, nanoparticles) via DSP or DSPE.

Controlled release via thioketal cleavage in oxidative environments.

Conjugation to amine-containing drugs, peptides, or targeting ligands through the carboxylic acid end.

DSP-PEG4-TK-COOH was incorporated into the liposomal membrane to enable ROS-sensitive release of surface-bound cargo via thioketal cleavage. The terminal carboxyl group was used to conjugate targeting ligands through EDC/NHS chemistry.

msds of DSP-PEG4-TK-COOH