FH535 cas:108409-83-2

FH535 is an inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ.1 At 15 µM,FH535 blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ.1 Presumably through these actions,FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway.1 FH535 is used to study the role of Wnt/β-catenin pathway in various cancer cell lines.

msds---FH535