MMAE CAS:474645-27-7

Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization.1 Monomethyl Auristatin E(MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity.It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.2,3 MMAE is typically coupled to the antibody via a protease-cleavable linker,allowing separation of the drug from the antibody following intracellular localization.

msds---MMAE