PHT-PPY-PDA-ANG NPs

The surface of PHT-PPY-PDA was further chemically conjugated with thiol-PEGylated brain‐targeting peptide ANG,which enhances BBB penetration through interacting with the LDLR1. Moreover, PHT-PPY-PDA exhibited a 125-fold escalation in conductivity compared to pure PPY, enabling rapid release of PHT upon the onset of epileptic discharges.
In an acute seizure model induced by pentylenetetrazole, treatment with PHT-PPY-PDA-ANG/Phenytoin-Polypyrrole-polydopamine-brain-targeting peptide ANG nanoparticles(10 mg PHT kg−1) and NIR irradiation significantly reduced seizure severity, increased latency to GS and improved survival rates. In a pilocarpine‐induced epilepsy model mimicking clinical SE, sustained release of PHT-PPY-PDA-ANG-10 + NIR remarkably mitigated SE severity with a low incidence of GS and no SE behavior.

msds of PHT‐PPY‐PDA‐ANG NPs