PQ401 CAS：196868-63-0

PQ401 is an inhibitor of insulin-like growth factor 1 receptor(IGF-1R).1 It inhibits autophosphorylation of the recombinant IGF-1R kinase domain(IC50=<1 μM)in a cell-free assay as well as IGF-1-stimulated IGF-1R autophosphorylation in MCF-7 cells(IC50=12μM).PQ401 reduces cell viability of U87MG glioma cells with an IC50 value of 5 μM and induces apoptosis and inhibits cell migration in a concentration-dependent manner.2 It inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro(IC50=6μM)and reduces tumor growth in an MCNeuA model of murine breast cancer when administered at doses of 50 and 100 mg/kg.1 PQ401 also has antimalarial activity against the P. 

msds---PQ401