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RMC-6291 CAS No.2641998-63-0
RMC-6291 CAS No.2641998-63-0
| Catalog # | Pkg Size | Price(USD) | Quantity | Buy this product |
|---|---|---|---|---|
| R-R-2975 | 1mg | 410.00 | + Add to cart |
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| R-R-2975 | 2mg | 710.00 | + Add to cart |
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Product description
RMC-6291/CAS No.2641998-63-0 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. RMC-6291 inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. RMC-6291 also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM.
| Appearance | N/A |
|---|---|
| Molecular Weight | 1012.00 |
| Purity | >90% |
| CAS | 2641998-63-0 |
| Formula | C55H78FN9O8 |
| Storage | -20℃, protected from light and moisture |
| Transportation | 4-25℃ temperature for up to 2 weeks |
| Stability | 1 year |
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