TG101348 cas:936091-26-8

Fedratinib(SAR302503,TG101348)is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays,35-and 334-fold more selective for JAK2 versus JAK1 and JAK3.Fedratinib also inhibits FMS-like tyrosine kinase 3(FLT3)and RET (c-RET)with IC50 of 15 nM and 48 nM,respectively. Fedratinib has potential antineoplastic activity.Fedratinib inhibits proliferation and induces apoptosis.

msds---TG101348