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R-DS-0043 DSPE-PEG2000-MAL-RGD(Arg-Gly-Asp-DPhe-Cys) A novel amphiphilic polymer block (dspe-peg2000-mal-RGD)was synthesized by linking RGD peptide with dspe-peg2000-mal.the BODIPY fluorescent dye was self-assembled with dspe-peg2000-mal-RGD to obtain a water-soluble bodipy-pc-RGD fluorescent probe complex,The optical properties of the fluorescent probe were measured by field emission transmission electron microscope and fluorescence microscope.It was found that the fluorescent probe had regular morphology, uniform size,about 143 nm in diameter,and had good near-infrared fluorescence characteristics. price>
R-DS-0044 DSPE-PEG3400-c(RGDfk)(cyclo (Arg-Gly-Asp-d-Phe-Lys)) Peptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs.It has been proved by experiments that peptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble properties of some small molecular drugs. price>
R-DS-1000 DSPE-PEG2000-CRGDK(Cys-Arg-Gly-Asp-Lys) Polyethylene glycol phospholipid is an excellent material to form liposomes, which can be used for gene transfection,vaccine delivery,drug delivery and targeted drug use.Phospholipids are hydrophobic and hydrophilic.It can be used to modify protein drugs,peptide compounds,organic small molecule drugs,biomaterials and so on.CRGDK is a straight chain. price>
R-DS-0045 DSPE-PEG3400-RGERPPR DSPE conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol,which has hydrophilicity and hydrophobicity.Polyethylene glycol phospholipid liposomes can be used for drug delivery,gene transfection and vaccine delivery.Pegylated phospholipids can significantly improve blood circulation time and stabilize drug encapsulation.These materials can also be used for targeted drug delivery by modifying ligands with target surfaces such as antibodies and peptides. price>
R-DS-0046 DSPE-PEG-c(RGDyK) The immunogenicity of C (rgdyk)-peg-dspe was derived from C (rgdyk)-peg-dspe, which eventually led to serious life-threatening toxicity.However,C(rgdyk) itself had no ability to induce immune response.The results of antibody typing showed that IgG3 was the main subtype of specific IgG antibody of C (rgdyk) modified liposomes,and the antibody production rate was fast,suggesting that C (rgdyk) modified liposomes belonged to T cell independent type-2 (TI-2) antigen. At the same time,it was found that cytotoxic chemotherapeutic drugs could mask the immunogenicity of C (rgdyk) modified liposomes,but there might be safety problems when they were used to deliver molecular targeted drugs with good tumor cell specificity and low adverse reactions in normal tissues. price>
R-DS-0047 DSPE-PEG-iNGR(CRNGRGPDC) LPNs were prepared with poly (histidine)(PHIS) as the core and di stearyl phosphatidylethanolamine polyethylene glycol (DSPE-PEG) and lecithin (EPC) as the single-layer shell.The anti-tumor drug DOX was encapsulated in LPNs and modified with the peptide ingr (crngrgpdc). price>
R-DS-0048 DSPE-PEG-NGR(ASP-Gly-Arg)-CD13 Polyethylene glycol phospholipid liposomes can be used for drug delivery,gene transfection and vaccine delivery.Polyethylene glycol phosphowax can significantly improve the blood circulation time and stabilize the drug package. These materials can also be used for targeted drug delivery by modifying surface ligands such as antibodies and peptides.The targeting peptide can target CD13 receptor which is over expressed in tumor neovascularization epithelial cells. price>
R-DS-0049 DSPE-PEG-FAL Non lysosomal cationic liposomes modify common cationic liposomes by introducing special fal peptides.Firstly,the product dspe-pec-fal was obtained by modifying dspe-peg-nh2 with fl polypeptide.The results of NMR and IR showed that the Al peptide was successfully connected to dspe-pec.Cationic lipid 2-dioleoylhydropropyl-3-n,N,k-trimethylammonium (DOTAP) was selected as cationic lipid,Liposomes modified by fal were prepared by film dispersion method using neutral auxiliary lipid dioleoyl phosphatidylethanolamine (DOPE) and the mixture of DSPE-PEC-NH2 and DSPE-PEG-FAL. price>
R-DS-0050 DSPE-PEG2000-D4 Peptide ligands containing six amino acids were screened for tumor cell epidermal growth factor (EGFR).Fluorescent liposomes containing D4 peptide were injected into tumor bearing mice via tail vein.In vivo imaging of small animals showed that fluorescent liposomes not only accumulated in tumor,but also had strong fluorescence signal in brain.Using loperamide as the"probe"and DSPE-PEG2000-D4 micelles as carriers,we found that D4 peptide has the ability to cross the blood-brain barrier through hot water bath tail contraction and formalin induced pain in mice. price>
R-DS-0051 DSPE-PEG2000-RLT Peptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs.It has been proved by experiments that peptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble properties of some small molecular drugs. price>
R-DS-0052 DSPE-PEG5000-LTV On the basis of PL(ID)NP nanoparticles,pl(V/D) np-ltv,a dual-mode CT/fluorescence nanoparticles targeting spontaneous breast cancer,was developed.HER2 targeted nanoparticles pl(I/D) np-ltv were prepared by modifying pl(I/D) NP with targeted phospholipid dspe-peg5000-ltv.The particle size of DLS was 64.9 ± 1.3 nm and had good serum stability. price>
R-DS-0054 DSPE-PEG2000-NGF NGF is a kind of polypeptide with various activities,which widely exists in various tissues of animals.It can nourish the injured peripheral nerve and promote regeneration and repair.When the peripheral nerve is injured,its corresponding cell body and axon can use exogenous NGF to transport retrogradely through the injured axon,making NGF reach the corresponding cell body.After the complex process of anabolism,NGF can be extended,It promotes axonal myelination. price>
R-DS-0055 DSPE-PEG-PVTRPPR PVTRPPR was modified on the surface of stealth liposomes,and pvtrppr polypeptide was used as the targeting head group.The drug loaded stealth liposome could target the drug to the tumor blood vessels through the tumor penetrating peptide pvtrppr,and penetrate the whole tumor tissue directly,so as to improve the therapeutic effect of the drug. price>
R-DS-0056 DSPE-PEG-T7(HAIYPRH) T7(HAIYPRH) is a short peptide screened by phage display technology,which can specifically bind to TfR with a binding constant as high as 10 nmol·L −1. Moreover,due to the different binding sites,endogenous TF will not inhibit, but will promote the binding of T7 modified nanoparticles to TfR.Therefore,T7 is more suitable as a target molecule,and there are many reports on the application of T7 peptide alone. price>
R-DS-0057 DSPE-PEG-R9 Cell penetrating peptide (CPP) is a kind of short peptide with strong penetration effect on cell membrane,which can promote cell uptake.Liposome modified by CPP can improve the rate of liposome entry into the cell,which is a new direction of targeted drug delivery carrier research. price>
R-DS-0058 DSPE-PEG-ADH1 Liposomes can passively enter tumor tissue through enhanced retention and retention effect(EPR).Compared with radiotherapy and chemotherapy alone, liposomes have certain clinical treatment advantages.However,the liposome can not reach the target site immediately after injection and stay at the tumor site for a long time. price>
R-DS-0059 DSPE-PEG3400-SPA Peptide is a compound formed by α-amino acids linked together by peptide bond, which is the intermediate product of protein hydrolysis.Peptides are widely used in medical research,drug release,nanotechnology and new materials research,cell culture.And the active compounds such as ligand research,peptide synthesis support,graft polymer,new materials and polyethylene glycol modified functional coating. price>
R-DS-0060 PH1-PEG-DSPE To verify the potential of targeting distribution of peptide guided liposome drug delivery system,the peptide can be coupled to the polyethylene glycol end of DSPE-PEG through the specific reaction between the sparse group and the maleimide group through the linker SPDP,and the linked products were analyzed by HPLC. We used post insertion technique to combine ph1-peg-dspe micelles with liposomes( HSPC:Chol Methods:DSPE-PEG=2:1:0.1) were co incubated to prepare targeted liposomes.However,the expression of phe2 in tumor cells was higher by Lipofectamine conjugation and liposome conjugation.Ph1 coupled with cisplatin loaded long circulating liposomes can greatly improve the cytotoxicity of cisplatin liposomes to Tie2 positive cells. price>
R-DS-0061 DSPE-PEG-TxID Peptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs.It has been proved by experiments that peptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble properties of some small molecular drugs.Peptide carrier targeting technology is known as a new generation of targeted drug development technology. price>
R-DS-0062 DSPE-PEG-TR The active and passive DSPE-PEG micelles containing coumarin-6 were constructed by linking tr peptide with DSPE-PEG.After that,we separated glioma stem cells by fluorescence activated immune cell sorting method and tumor ball culture method. By confocal microscopy and flow cytometry,the uptake of TR modified micelles by tumor stem cells was increased,which proved that tr modified micelles were targeted in vitro. price>