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R-DS-0068 MC-PEG-DSPE After doxorubicin was loaded,MC-DA7R-PEG-DSPE liposomes could effectively inhibit tumor angiogenesis and pseudo angiogenesis,promote apoptosis of glioma cells,and reduce the number of glioma stem cells,thus enhancing the anti glioma effect of doxorubicin.The median survival time of the model animals was longer than that of single targeted molecular modified liposomes (MC-PEG-DSPE liposome and DA7R-PEG-DSPE liposome) 63.6% and 38.5% respectively. price>
R-R-1162 PI3K-IN-46 CAS No.304645-61-2 PI3K-IN-46 (Intermediate 4)/CAS No.304645-61-2 is an intermediate in the synthesis of PI3K inhibitor (2-imino-azolinone-vinyl fused-benzene derivative) that can be used for the research of autoimmune disorders, cardiovascular diseases, and neurodegenerative diseases. price>
R-PL-0124 PAA-PEG-SH Polyacrylic acid-polyethylene glycol-Thiol,PAA-PEG-SH from ruixi Polyacrylic acid-polyethylene glycol-Thiol (PLLA-PEG-Thiol ) is a functional amphiphilic block copolymer to prepare targeted micelles or nanoparticles.Block copolymer micelles are widely used in drug delivery applications.PEG is the hydrophilic part and PAAis the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded. price>
R-TD-0010 W-QDs The water-soluble quantum dots,which are chemically modified,have good biocompatibility,can be connected specifically,and have little harm to organism,and can be labeled and detected in vivo.Fluorescent dyes are generally toxic and biocompatibility is poor. price>
R-DS-0069 DA7R-PEG-DSPE After doxorubicin was loaded,MC-DA7R-PEG-DSPE liposomes could effectively inhibit tumor angiogenesis and pseudo angiogenesis,promote apoptosis of glioma cells,and reduce the number of glioma stem cells,thus enhancing the anti glioma effect of doxorubicin.The median survival time of the model animals was longer than that of single targeted molecular modified liposomes (MC-PEG-DSPE liposome and DA7R-PEG-DSPE liposome) 63.6% and 38.5% respectively. price>
R-R-1163 Pichromene CAS No.883046-50-2 Pichromene (S14161)/CAS No.883046-50-2 is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research. price>
R-PL-0125 PAA-PEG-Biotin Polyacrylic acid-polyethylene glycol-Biotin,PAA-PEG-Biotin from ruixi Polyacrylic acid-polyethylene glycol-Biotin(PAA-PEG-Biotin) is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
R-CD-002 DBCO-C4-NHS Ester DBCO-C4-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media.The extended 4-carbon atom spacer arm drastically improves solubility of this reagent in commonly used organic solvents such as dichloromethane, chloroform,THF,and ethyl acetate.In addition extended spacer arm significantly improves derivatization efficiency and stability of conjugates. price>
R-DS-0070 DSPE-PEG-M2pep(YEQDPWGVKWWY) Peptides as receptor targeted anti-tumor carrier are more and more used to improve the effect of chemotherapy drugs.It has been proved by experiments that peptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble properties of some small molecular drugs.The liposome can not stay in the tumor site for a long time after intravenous injection,but the targeted liposome prepared by connecting peptide on the surface of liposome can reach the target site immediately after intravenous injection and stay in the tumor site for a long time. The drug released from the liposome can improve the therapeutic effect of tumor.Polyethylene glycol phospholipid is an excellent material to form liposomes,which can be used for gene transfection, vaccine delivery,drug delivery and targeted drug use. price>
R-R-1164 Umbralisib R-enantiomer CAS No.1532533-69-9 Umbralisib R-enantiomer (TGR-1202 R-enantiomer)/CAS No.1532533-69-9 is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. price>
R-PL-0126 PAA-PEG-CHO Polyacrylic acid-polyethylene glycol-aldehyde,PAA-PEG-CHO from ruixi Polyacrylic acid-polyethylene glycol-aldehyde(PAA-PEG-CHO ) is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
R-R1910 RB-PLGA Rhodamine B is a synthetic dye with bright pink color.It is red to violet powder, blue red in aqueous solution and red in alcohol solution.It is commonly used as a fluorescent staining agent for cells in the laboratory. price>
R-DS-0071 GLP-1-PEG-DSPE Glucagon like peptide-1 (GLP-1) is a kind of brain gut peptide secreted by ileal endocrine cells.It is mainly used as the target of type 2 diabetes drugs.PEG modification makes the previously insoluble peptides less soluble and highly mobile.PEG modification can reduce the filtration of drugs by kidney,reduce its pyrogen,reduce the digestion of protease, and enhance its transport capacity by protecting the body immune system.GLP-1 has two Lys located in the inactive site, which provides great flexibility for modification. price>
R-R-1165 WYE-687 dihydrochloride CAS No.1702364-87-1 WYE-687 dihydrochloride/CAS No.1702364-87-1 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively. price>
R-PL-0127 PAA-PEG-OPSS Polyacrylic acid-polyethylene glycol-OPSS,PAA-PEG-OPSS from ruixi Polyacrylic acid-polyethylene glycol-OPSS(PAA-PEG-OPSS) is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
R-DBCO-003 Sulfo CY7-DBCO Cy7 is a bright and light resistant near-infrared probe.Cy7 dbco is a water-soluble hydrophilic dye.It is usually an analytical reagent that requires minimal nonspecific binding and excellent brightness.The fluorescence of cy7 dbco is not sensitive to pH from pH 4 to pH 10,and the spontaneous fluorescence of biological samples produced in this spectral region is very small.The fluorescence of this long wavelength cyanine dye is invisible to the human eye, but can be easily detected by most imaging systems. price>
R-DS-0072 HP2-PEG2000-DSPE HER2,also known as c-erb2,consists of 922 adenine,1382 cytosine,1346 guanine and 880 thymine.HER2 protein mediated signal transduction pathways include Ras/Raf/mitogen activated protein kinase (MAPK),phosphatidylinositol 3-hydroxykinase (PI3K)/Akt pathway,signal transduction and transcriptional activation (STAT) pathway and PLC pathway. price>
R-R-1166 PI3K-IN-22 CAS No.1202884-94-3 PI3K-IN-22/CAS No.1202884-94-3 is a PI3Kα/mTOR dual kinase inhibitor. PI3K-IN-22 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. PI3K-IN-22 can be used for the research of cancer. price>
R-PL-0128 PAA-PEG-OH Polyacrylic acid-polyethylene glycol-hydroxyl,PAA-PEG-OH from ruixi Polyacrylic acid-polyethylene glycol-hydroxyl(PAA-PEG-OH)is a linear A-B-C type amphiphilic triblock copolymers. It can be used in preparation of hydrogel for drug encapsulation and drug delivery. price>
R-DBCO-002 Sulfo CY5-DBCO Cy5 dbco is a kind of azide reaction probe,which is used to image azide labeled biomolecules through copper free click reaction.Dbco partially reacts with azide to form stable triazole,which does not need Cu catalyst or high temperature.The fluorescence probe is water-soluble,and its fluorescence is not sensitive to pH between pH 4 and pH 10. price>