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R-M-500 Ac-Arg-Gly-Lys(Ac)-AMC trifluoroacetate salt Ac-RGK(Ac)-AMC(CAS :660846-97-9),fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. price>
R-R-1657 Azadirachtin CAS No.11141-17-6 Azadirachtin/CAS No.11141-17-6, one of the most promising botanical insecticides, is widely used for pest control. Azadirachtin induces apoptosis in insect cell lines, including Sf9, SL-1 and BTI-Tn-5B1-4. price>
R-M-501 Ac-Arg-Leu-Arg-AMC trifluoroacetate salt Ac-RLR-AMC(CAS :929903-87-7),fluorogenic substrate for assaying the trypsin-like activity of purified proteasomes (Km = 78 μM). price>
R-R-1658 Chaetoglobosin A CAS No.50335-03-0 Chaetoglobosin A/CAS No.50335-03-0, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration. price>
R-M-502 Ac-Arg-Ser-Leu-Lys-AMC trifluoroacetate salt Ac-RSLK-AMC(CAS : 259176-76-6),a fluorogenic substrate for Site-1 protease (S1P), a mammalian subtilisin-related serine protease that cleaves sterol regulatory element-binding proteins (SREBPs).The peptide sequence RSLK corresponds to the internal propeptide cleavage site that generates active S1P. price>
R-R-1659 Casein Kinase inhibitor A51 CAS No.2079068-74-7 Casein Kinase inhibitor A51/CAS No.2079068-74-7 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities. price>
R-M-503 Ac-Asp-Arg-Leu-Asp-Ser-OH Ac-Asp-Arg-Leu-Asp-Ser-OH(CAS:153959-57-0),Ac-DRLDS from ruixi.The acetylated pentapeptide Ac-DRLDS inhibits tumor cell adhesion to laminin, fibronectin, vitronectin, and RGDS-IgG substrates. Ac-DRLDS also inhibits tumor cell adhesion to CS-1-IgG as well as the CS-1-derived peptide (EILDV), in a concentration-dependent manner. Although the inhibitory effect was less than that of EILDV, this peptide retains the properties of both RGDS and EILDV. price>
R-R-1660 Patulin CAS No.149-29-1 Patulin (Terinin)/CAS No.149-29-1 is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage. price>
R-M-504 Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH,CAS : 66641-26-7 from ruixi.Renin cleavage of Ac-DRVYIHPFHLLVYS yields N-terminally acetylated angiotensin I and LVYS. price>
R-R-1661 (Rac)-Hesperetin-d3 CAS No.1346605-26-2 (Rac)-Hesperetin-d3/CAS No.1346605-26-2 is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. price>
R-M-505 NAAG NAAG,N-Acetyl-L-aspartyl-L-glutamic acid(CAS :3106-85-2) from ruixi.An endogenous dipeptide with high affinity for a brain glutamate receptor. NAAG is the most abundant peptide neurotransmitter in the mammalian central nervous system. price>
R-R-1662 Oxychlororaphine CAS No.550-89-0 Oxychloroaphine/CAS No.550-89-0 could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer. price>
R-M-506 Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-L-lactoyl-Ser-Lys(DABCYL)-NH₂ ammonium salt Internally quenched fluorogenic (FRET) substrate for the continuous monitoring of HCV NS3 protease activity. price>
R-R-1663 EPZ020411 hydrochloride CAS No.2070015-25-5 EPZ020411 hydrochloride/CAS No.2070015-25-5 is a selective inhibitor of PRMT6 with an IC50 of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer. price>
R-M-507 Ac-Asp(Glu-OH)-OH A non-hydrolyzable NAAG isomer which acts as selective metabotropic glutamate receptor-3 (mGluR3) antagonist and NAAG peptidase inhibitor. price>
R-R-1664 VTP50469 fumarate CAS No.2169919-29-1 VTP50469 fumarate/CAS No.2169919-29-1 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 fumarate has potently anti-leukemia activity. price>
R-M-508 Ac-Asp-Glu-Val-Asp-AFC Ac-Asp-Glu-Val-Asp-AFC (Ac-DEVD-AFC) is a sensitive fluorescent substrate for the assay of caspase-3 activity. The trifluoromethyl substituent of the fluorophore improves the membrane permeability of the substrate. price>
R-R-1665 Seribantumab CAS No.1334296-12-6 Seribantumab (MM 121)/CAS No.1334296-12-6 is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models. price>
R-M-509 Ac-Asp-Glu-Val-Asp-aldehyde (pseudo acid) Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3.PARP cleavage occurs at the onset of apoptosis.The peptide aldehyde was able to attenuate apoptotic events in vitro. price>
R-R-1666 VTP50469 CAS No.2169916-18-9 VTP50469/CAS No.2169916-18-9 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity. price>