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Catalog	name	Description	price
R-C-430	PDMS-b-PAA	PAA alias acrylic resin emulsion;acrylic modified resin;auxiliary tanning agent; acrylic monomer polymer.Poly two methyl siloxane(Polydimethylsiloxane) is a hydrophobic silicone material,also known as two methyl silicone oil.	price>
R-R-2130	Zeaxanthin dipalmitate CAS No.144-67-2	Zeaxanthin dipalmitate (Physalien)/CAS No.144-67-2 is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (Kd=81.2 nM) and adiponectin receptor 1 (AdipoR1; Kd=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP).	price>
R-C-431	P2VP-b-PEO	P2VP-b-PEO is also a pH responsive amphiphilic polymer.When the pH value changes from acidic to neutral or alkaline,the copolymer formed by poly (2-vinylpyridine) and polyoxyethylene (p2vp-b-peo) can undergo a reversible micellization process in aqueous solution through protonation.P2VP can also make triblock copolymers pH responsive.Lee et al. Developed a series of block copolymers with tertiary amine groups.Their micellization process is pH responsive.	price>
R-R-2131	PF-543 CAS No.1415562-82-1	PF-543 (Sphingosine Kinase 1 Inhibitor II)/CAS No.1415562-82-1 is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy.	price>
R-C-432	P2VP-b-PMAA	Biodegradable block copolymers are new drug delivery materials with potential development.They can adjust their physical and chemical properties by adjusting the composition of blocks or adding new blocks that meet the requirements.They have good biocompatibility.They are increasingly used as carriers for a variety of drug delivery systems,including non bioactive drugs and bioactive drugs,such as proteins and peptides Antigen,etc.	price>
R-R-2132	Laduviglusib trihydrochloride CAS No.1782235-14-6	Laduviglusib (CHIR-99021) trihydrochloride/CAS No.1782235-14-6 is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy.	price>
R-C-433	ABT-888	ABT-888 is an effective inhibitor of PARP.It has good oral bioavailability,can cross the blood-brain barrier,and can enhance temozolomide,platinum, cyclophosphamide and radiation.This broad spectrum of chemical and radioenhancement makes this compound an attractive candidate for clinical evaluation.	price>
R-R-2133	AC-73 CAS No.775294-71-8	AC-73/CAS No.775294-71-8 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells. AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells.	price>
R-C-434	Omipalisib (GSK2126458)	Omipalisib (GSK2126458)is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ,mTORC1/2,respectively.Omipalisib has anti-cancer activity.	price>
R-R-2134	(rel)-ML-SI3 CAS No.2108567-79-7	(rel)-ML-SI3/CAS No.2108567-79-7 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.	price>
R-C-435	BMS777607	Bms-777607 is a met related inhibitor, which acts on c-Met,Axl,Ron and TYRO3 with IC50 of 3.9 nm,1.1 nm,1.8 nm and 4.3 nm respectively in cell-free assay.The selectivity of bms-777607 on met related targets is 40 times higher than that on Lck,VEGFR-2 and TrkA/B,and more than 500 times higher than that on other receptor and non receptor kinases.	price>
R-R-2135	ZX-29 CAS No.2254805-62-2	ZX-29/CAS No.2254805-62-2 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect.	price>
R-C-436	Dapagliflozin(BMS5121458)	Dapagliflozin(BMS512148)is a selective,orally active inhibitor of the renal sodium-glucose co-transporter type 2(SGLT2)is in development for the treatment of type 2 diabetes mellitus.Dapagliflozin inhibits subtype 2 of SGLT2 which are responsible for at least 90% of the glucose reabsorption in the kidney.Blocking this transporter mechanism causes blood glucose to be eliminated through the urine.In clinical trials,dapagliflozin lowered HbA1c by 0.90 percentage points when added to metformin.	price>
R-R-2136	BOLD-100 free base CAS No.783324-98-1	BOLD-100 (NKP-1339; IT-139) free base/CAS No.783324-98-1 is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.The free form of the compound is prone to instability, it is advisable to consider the stable salt form (BOLD-100) that retains the same biological activity.	price>
R-C-437	Telaprevir (VX-950)	Trapivir is an effective and selective reversible HCV NS3-4A protein inhibitor, which acts on NS3 protease domain and NS4A cofactor peptide of genotype 1(strain h).Vx-950 is an effective and selective peptide like inhibitor of hepatitis C virus NS3-4A serine protease.It shows excellent antiviral activity in both type 1b HCV replicon cells (50% inhibition concentration [IC50]=354nm) and human fetal liver cells(IC50=280nm) infected with sera from type 1A HCV positive patients.	price>
R-R-2137	TSPO ligand-1 CAS No.4560-08-1	TSPO ligand-1/CAS No.4560-08-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.	price>
R-C-438	Telatinib (BAY 57-9352)	Telatinib has low affinity for Raf kinase pathway,epidermal growth factor receptor family,fibroblast growth factor receptor(FGFR) family or Tie-2 receptor.Tiratinib is metabolized by a variety of cytochrome P450 (CYP) subtypes, including CYP3A4/3A5,cyp2c8, CYP2C9 and CYP2C19,as well as uridine diphosphate glucuronosyltransferase 1A4 (ugt1a4).The formation of N-glucuronide is the main biotransformation pathway of tiratinib.	price>
R-R-2138	Trimetazidine-d8 dihydrochloride CAS No.1219795-37-5	Trimetazidine-d8 (dihydrochloride)/CAS No.1219795-37-5 is the deuterium labeled Trimetazidine dihydrochloride. Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.	price>
R-C-439	gsk1904529A	Gsk-1904529a is an IGF-1R inhibitor,which has broad application prospects in the treatment of igf-ir-dependent tumors.Gsk1904529a selectively inhibited IGF-IR and IR with IC50 of 27 and 25 nmol/L,respectively.Gsk1904529a blocks autophosphorylation and downstream signal transduction of receptor,leading to cell cycle arrest.It inhibits the proliferation of cell lines from solid and hematological malignancies.Multiple myeloma and Ewing sarcoma cell lines are the most sensitive.	price>
R-R-2139	PI-1840 CAS No.1401223-22-0	PI-1840/CAS No.1401223-22-0 is a potent and selective chymotrypsin-like (CT-L) inhibitor for with an IC50 value of 27 nM. PI-1840 inhibits cell proliferation and arrest cell cycle at G2/M phase. PI-1840 induces apoptosis and induces autophagy. PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α.	price>

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