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Catalog	name	Description	price
R-C-440	LY2157299	Galunisertib(LY2157299)is selective TGF-receptor kinase inhibitor.Galunisertib was found to inhibit the growth in an in vitro clonogenic assay in 6.3%(5/79)of the examined PDX.	price>
R-R-2140	CUR5g CAS No.1370032-20-4	CUR5g/CAS No.1370032-20-4 is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin (HY-17394) against A549 cells both in vitro and in vivo.	price>
R-C-441	DMXAA(AS1404,ASA404)	DMXAA is an apoptosis inducer,and an anti-vascular.DMXAA is an inhibitor of NQO1, Flk-1 and Flt-1.	price>
R-R-2141	GW406108X CAS No.1644443-92-4	GW406108X/CAS No.1644443-92-4 is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.	price>
R-C-442	Brivanib(bms-540215)	Brivanib is an ATP-competitive inhibitor against human Flk-1(VEGFR-2)and mouse Flk-1 with IC50 of 25 nM and 89 nM,respectively.Brivanib also inhibits Flt-1 (VEGFR-1)and Flg (FGFR-1) with IC50 of 0.38 and 0.148 μM.Brivanib displays antitumor activities in H3396 xenograft.This compound completely inhibits the tumor growth,with TGI of 85% and 97%, respectively.	price>
R-R-2142	Manzamine A hydrochloride CAS No.104264-80-4	Manzamine A hydrochloride/CAS No.104264-80-4, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.	price>
R-C-443	Brivanib alaninate(BMS-582664)	Brivanib Alaninate is the alaninate salt of a vascular endothelial growth factor receptor 2(VEGFR2) inhibitor with potential antineoplastic activity.Brivanib strongly binds to and inhibits VEGFR2,a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells;inhibition of VEGFR2 may result in inhibition of tumor angiogenesis,inhibition of tumor cell growth,and tumor regression.	price>
R-R-2143	Vacuolin-1 CAS No.351986-85-1	Vacuolin-1/CAS No.351986-85-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation. Vacuolin-1 can induce vacuole formation and increase the percentage of enucleated cells.	price>
R-C-444	vx-702	VX-702 inhibits p38 MAPK, preventing p38 MAPK-dependent inflammatory cytokine release.VX-702 is in development to treat inflammation and cardiovascular diseases and currentlyshows mixed results in clinical trials as a potential treatment for rheumatoid arthritis.In vitro,Vx-702 decreases platelet lesioning in storage without affecting platelet function.	price>
R-R-2144	Gefitinib-d3 CAS No.1173976-40-3	Gefitinib-d3 (ZD1839-d3)/CAS No.1173976-40-3 is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.	price>
R-C-445	Linifanib (ABT-869)	Linifanib(ABT-869) is a novel,potent ATP-competitive VEGFR/PDGFR inhibitor for KDR(IC50:4 nM),CSF-1R (IC50:3 nM),Flt-1/3(IC50:3/4 nM)and PDGFRβ(IC50:66 nM).Linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases,such as FMS-related tyrosine kinase receptor-3 (FLT3).	price>
R-R-2145	NL-1 CAS No.188532-26-5	NL-1/CAS No.188532-26-5 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 µM and 56.26 µM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway.	price>
R-C-446	Marbofloxacin	Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.	price>
R-R-2146	Acetyl Coenzyme A trisodium CAS No.102029-73-2	Acetyl-coenzyme A (Acetyl-CoA) trisodium/CAS No.102029-73-2 is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis.	price>
R-C-447	Moxifloxacin	Moxifloxacin(BAY12-8039)is a fourth-generation synthetic fluoroquinolone antibacterial agent.Moxifloxacin is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis,acute bacterial exacerbations of chronic bronchitis,and community-acquired pneumonia.	price>
R-R-2147	Dimethyl fumarate-d2 CAS No.23057-98-9	Dimethyl fumarate-d2/CAS No.23057-98-9 is the deuterium labeled Dimethyl fumarate. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.	price>
R-C-448	NPS-2143	Nps-2143(sb-262470a),an oral active calcium solubilizer,is a selective calcium sensitive receptor(CaSR)antagonist.Nps-2143(sb-262470a)increased the cytosolic Ca2+concentration (IC50=43 nm) by activating Ca2+receptor in HEK 293 cells expressing human Ca2 + receptor.	price>
R-R-2148	CA77.1 CAS No.2412270-22-3	CA77.1/CAS No.2412270-22-3 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in lysosomes.	price>
R-C-449	Rucaparib (AG-014699) phosphate cas:459868-92-9	Rucaparib(AG-014699,PF-01367338)is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay,also showing binding affinity to eight other PARP domains.	price>
R-R-2149	Carvedilol-d4 CAS No.1133705-56-2	Carvedilol-d4/CAS No.1133705-56-2 is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome.	price>

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