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Catalog	name	Description	price
R-C-450	Selumetinib(AZD6244) CAS:606143-52-6	Selumetinib(AZD6244,ARRY-142886) is a potent, highly selective MEK inhibitor with IC50 of 14 nM for MEK1 and Kd value of 530 nM for MEK2.It also inhibits ERK1/2 phosphorylation with IC50 of 10 nM,no inhibition to p38α,MKK6,EGFR,ErbB2, ERK2,B-Raf,etc.Selumetinib suppresses cell proliferation,migration and trigger apoptosis.	price>
R-R-2150	Acacetin CAS No.480-44-4	Acacetin/CAS No.480-44-4 is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research.	price>
R-C-451	GSK1070916 CAS:942918-07-2	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/Cwith IC50 of 3.5 nM/6.5 nM.It displays 100-fold selectivity against the closely related Aurora A-TPX2 complex.	price>
R-R-2151	Forskolin CAS No.66575-29-9	Forskolin (Coleonol)/CAS No.66575-29-9 is a potent activator of adenylate cyclase with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces the differentiation of various cell types and activates the pregnane X receptors (PXR) and FXR. Forskolin exerts an inotropic effect on the heart and has antiplatelet and antihypertensive actions. Forskolin also induces autophagy.	price>
R-C-452	Trametinib（GSK1120212) CAS:871700-17-3	Trametinib (GSK1120212,JTP-74057, Mekinist)is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays,no inhibition of the kinase activities of c-Raf,B-Raf,ERK1/2.Trametinib activates autophagy and induces apoptosis.	price>
R-R-2152	Trimetazidine CAS No.5011-34-7	Trimetazidine/CAS No.5011-34-7 is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.	price>
R-C-453	A-674563 CAS:552325-73-2	A-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays,modest potent to PKA and 30-fold selective for Akt1 over PKC.	price>
R-R-2153	Trimetazidine dihydrochloride CAS No.13171-25-0	Trimetazidine dihydrochloride/CAS No.13171-25-0 is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.	price>
R-C-454	Alisertib(MLN8237) CAS:1028486-01-2	Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay.It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest,apoptosis and autophagy.	price>
R-R-2154	Gefitinib-d6 CAS No.1228664-49-0	Gefitinib-d6/CAS No.1228664-49-0 is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.	price>
R-C-455	AS605240 CAS:648450-29-7	AS-605240 selectively inhibits PI3Kγwith IC50 of 8 nM,over 30-fold and 7.5-fold more selective for PI3Kγ than PI3Kδ/β and PI3Kα in cell-free assays, respectively.	price>
R-R-2155	Liensinine Diperchlorate CAS No.5088-90-4	Liensinine Diperchlorate/CAS No.5088-90-4 is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.	price>
R-C-456	Dibenzazepine (YO-01027) CAS:209984-56-5	Yo-01027 is a dipeptide type γ-secretase inhibitor with IC50 of 2.6 nm and 2.9 nm,respectively.Yo-01027 is an anti Alzheimer drug.Yo-01027 interacts directly with γ-secretase complex.Different from other γ-secretase inhibitors,yo-01027 targets different functional domains of the complex.Yo-01027 targets the N-terminal presenilin fragment and another gamma secretase inhibitor compound E(CPN E),while dfk167 and dapt bind to the catalytic sites of presenilin aspartate protease subunit and C-terminal presenilin fragment,respectively.In one study,yo-01027 and cpne showed no significant difference in blocking appl and notch cleavage,indicating that the IC50 values of the two substrates were statistically equal.	price>
R-R-2156	Chloroquine-d5 CAS No.1854126-41-2	Chloroquine-d5/CAS No.1854126-41-2 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).	price>
R-C-457	Gedatolisib（PKI587） CAS:1197160-78-3	Gedatolisib (pf-05212384,pki-587) is a highly effective dual inhibitor of PI3K α,PI3K γ and mTOR.The IC50 of gedatolisib (pf-05212384,pki-587) is 0.4nm,5.4nm and 1.6nm in cell-free experiment,respectively.Pki-587 also showed potency against the most common PI3K mutation, especially h1047r and e545k,with IC50 of 0.6Nm and 0.6Nm,respectively.The inhibitory effect of pf-05212384 on PI3Ks and mtors inhibited the growth of mda-361 and pc3-mm2 cell lines with IC50 of 4 nm and 13.1 nm,respectively.	price>
R-R-2157	RSVA405 CAS No.140405-36-3	RSVA405/CAS No.140405-36-3 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity.	price>
R-C-458	LY2886721 CAS:1262036-50-9	Ly2886721 is a bace inhibitor for the treatment of Alzheimer disease.The IC50 of recombinant hbace-1 was 20.3 nm.Human BACE2 was inhibited by IC50 of 10.2 nm.It did not inhibit other aspartic proteases,such as cathepsin D,pepsin and renin.A potential drug for Alzheimer disease.The IC50 values of a β 1-40 and a β 1-42 were 18.5 nm and 19.7 nm,respectively,in HEK-293 swe cells and PDAPP neurons (IC50 ~ 10 nm).	price>
R-R-2158	Crustecdysone CAS No.5289-74-7	Crustecdysone (20-Hydroxyecdysone)/CAS No.5289-74-7 is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).	price>
R-C-459	GSK690693 CAS:937174-76-0	Gsk690693 is a pan Akt inhibitor targeting AKT1/2/3.The IC50 of gsk690693 is 2 nm /13nm/9 nm in cell-free analysis.Gsk690693 is also sensitive to pKa,PrKX and PKC isozymes of AGC kinase family.Gsk690693 also inhibited AMPK and dapk3 of CaMK family with IC50 of 50nm and 81nm,respectively.	price>
R-R-2159	Autophagy inducer 3 CAS No.2691054-63-2	Autophagy inducer 3/CAS No.2691054-63-2 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins.	price>

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